Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis
Abstract Background Actinic keratosis (AK), or solar keratosis, is a precancerous condition of the skin, mainly caused by excessive and chronic exposure to ultraviolet radiation. Pigmented AK (pAK) is a rare variant of AK. Photodynamic therapy (PDT) is widely used to treat the classical variant of A...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-05-01
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| Series: | Dermatology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13555-023-00924-0 |
| _version_ | 1797801600774832128 |
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| author | Ewelina Mazur Adam Reich |
| author_facet | Ewelina Mazur Adam Reich |
| author_sort | Ewelina Mazur |
| collection | DOAJ |
| description | Abstract Background Actinic keratosis (AK), or solar keratosis, is a precancerous condition of the skin, mainly caused by excessive and chronic exposure to ultraviolet radiation. Pigmented AK (pAK) is a rare variant of AK. Photodynamic therapy (PDT) is widely used to treat the classical variant of AK, but very limited data are available on the use of PDT in patients with pAK. The objective of this study was to assess the usefulness of PDT in the treatment of pAK. Methods The study included 16 patients with 20 pAK lesions treated with PDT. All skin lesions were clinically and dermatoscopically assessed for typical features characteristic of pAK. Reflectance confocal microscopy (RCM) was also used to assess keratinocyte atypia, confirm pAK diagnosis, and rule out other disease entities. Results After three PDT sessions, the complete resolution of all clinical features of pAK was observed in 80% of the studied lesions. Dermatoscopically, 65% of the lesions achieved 100% response and no cellular atypia was seen in the follow-up RCM images of 85% of lesions. Conclusions Photodynamic therapy is an effective treatment modality for pAK in fair-skinned individuals. |
| first_indexed | 2024-03-13T04:53:03Z |
| format | Article |
| id | doaj.art-ccc0db01495241638c7e718620b89a8b |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-03-13T04:53:03Z |
| publishDate | 2023-05-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-ccc0db01495241638c7e718620b89a8b2023-06-18T11:07:04ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722023-05-011361265127610.1007/s13555-023-00924-0Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic KeratosisEwelina Mazur0Adam Reich1Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow UniversityDepartment of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow UniversityAbstract Background Actinic keratosis (AK), or solar keratosis, is a precancerous condition of the skin, mainly caused by excessive and chronic exposure to ultraviolet radiation. Pigmented AK (pAK) is a rare variant of AK. Photodynamic therapy (PDT) is widely used to treat the classical variant of AK, but very limited data are available on the use of PDT in patients with pAK. The objective of this study was to assess the usefulness of PDT in the treatment of pAK. Methods The study included 16 patients with 20 pAK lesions treated with PDT. All skin lesions were clinically and dermatoscopically assessed for typical features characteristic of pAK. Reflectance confocal microscopy (RCM) was also used to assess keratinocyte atypia, confirm pAK diagnosis, and rule out other disease entities. Results After three PDT sessions, the complete resolution of all clinical features of pAK was observed in 80% of the studied lesions. Dermatoscopically, 65% of the lesions achieved 100% response and no cellular atypia was seen in the follow-up RCM images of 85% of lesions. Conclusions Photodynamic therapy is an effective treatment modality for pAK in fair-skinned individuals.https://doi.org/10.1007/s13555-023-00924-0Pigmented actinic keratosispAKPhotodynamic therapyPDTDermatoscopyReflectance confocal microscopy |
| spellingShingle | Ewelina Mazur Adam Reich Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis Dermatology and Therapy Pigmented actinic keratosis pAK Photodynamic therapy PDT Dermatoscopy Reflectance confocal microscopy |
| title | Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
| title_full | Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
| title_fullStr | Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
| title_full_unstemmed | Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
| title_short | Photodynamic Therapy is an Effective Treatment of Facial Pigmented Actinic Keratosis |
| title_sort | photodynamic therapy is an effective treatment of facial pigmented actinic keratosis |
| topic | Pigmented actinic keratosis pAK Photodynamic therapy PDT Dermatoscopy Reflectance confocal microscopy |
| url | https://doi.org/10.1007/s13555-023-00924-0 |
| work_keys_str_mv | AT ewelinamazur photodynamictherapyisaneffectivetreatmentoffacialpigmentedactinickeratosis AT adamreich photodynamictherapyisaneffectivetreatmentoffacialpigmentedactinickeratosis |