Role of actin-binding proteins in the regulation of cellular mechanics
The viscoelastic parameters of the cell can report on the cell state, cellular processes and diseases. Cell mechanics strongly rely on the properties of the cytoskeleton, an important system of subcellular filaments, especially on the high-level structures that actin forms together with actin-bindin...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
|
| Series: | European Journal of Cell Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171933522000449 |
| _version_ | 1818507771941748736 |
|---|---|
| author | A.V. Vakhrusheva A.V. Murashko E.S. Trifonova Yu.M. Efremov P.S. Timashev O.S. Sokolova |
| author_facet | A.V. Vakhrusheva A.V. Murashko E.S. Trifonova Yu.M. Efremov P.S. Timashev O.S. Sokolova |
| author_sort | A.V. Vakhrusheva |
| collection | DOAJ |
| description | The viscoelastic parameters of the cell can report on the cell state, cellular processes and diseases. Cell mechanics strongly rely on the properties of the cytoskeleton, an important system of subcellular filaments, especially on the high-level structures that actin forms together with actin-binding proteins (ABPs). In normal cells, components of the cytoskeleton are highly integrated, and their functions are well orchestrated. In contrast, impaired expression and functioning of ABPs lead to the increasing ability of cancer cells to resist chemotherapy and metastasize. ABP-mediated changes in the cytoskeleton architecture can lead to changes in the mechanical properties of the actin network, both locally and at the level of the whole cell. Until now, in cancer-related studies, mechanical data have been used less frequently, compared to biochemical tests or cell migration assays. Here, we will review current methods for analyzing the mechanical properties of cells and provide the available data on the contribution of ABPs in determining cell mechanical properties important for the investigation of cellular functions, particularly in cancers. |
| first_indexed | 2024-12-10T22:22:36Z |
| format | Article |
| id | doaj.art-ccc1af4d499d4e4ea60ff49b061be614 |
| institution | Directory Open Access Journal |
| issn | 0171-9335 |
| language | English |
| last_indexed | 2024-12-10T22:22:36Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj.art-ccc1af4d499d4e4ea60ff49b061be6142022-12-22T01:31:16ZengElsevierEuropean Journal of Cell Biology0171-93352022-06-011013151241Role of actin-binding proteins in the regulation of cellular mechanicsA.V. Vakhrusheva0A.V. Murashko1E.S. Trifonova2Yu.M. Efremov3P.S. Timashev4O.S. Sokolova5Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, RussiaFaculty of Physics, Lomonosov Moscow State University, 119991 Moscow, Russia; Institute for Regenerative Medicine, Sechenov University, 119991 Moscow, RussiaFaculty of Biology, Lomonosov Moscow State University, 119234 Moscow, RussiaInstitute for Regenerative Medicine, Sechenov University, 119991 Moscow, Russia; World-Class Research Center “Digital Biodesign and Personalized Healthcare”, 119991 Moscow, RussiaInstitute for Regenerative Medicine, Sechenov University, 119991 Moscow, Russia; World-Class Research Center “Digital Biodesign and Personalized Healthcare”, 119991 Moscow, Russia; Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, RussiaFaculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia; Biology Department, Shenzhen MSU-BIT University, 517182 Shenzhen, China; Corresponding author at: Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.The viscoelastic parameters of the cell can report on the cell state, cellular processes and diseases. Cell mechanics strongly rely on the properties of the cytoskeleton, an important system of subcellular filaments, especially on the high-level structures that actin forms together with actin-binding proteins (ABPs). In normal cells, components of the cytoskeleton are highly integrated, and their functions are well orchestrated. In contrast, impaired expression and functioning of ABPs lead to the increasing ability of cancer cells to resist chemotherapy and metastasize. ABP-mediated changes in the cytoskeleton architecture can lead to changes in the mechanical properties of the actin network, both locally and at the level of the whole cell. Until now, in cancer-related studies, mechanical data have been used less frequently, compared to biochemical tests or cell migration assays. Here, we will review current methods for analyzing the mechanical properties of cells and provide the available data on the contribution of ABPs in determining cell mechanical properties important for the investigation of cellular functions, particularly in cancers.http://www.sciencedirect.com/science/article/pii/S0171933522000449Actin-binding proteinsActinCytoskeleton, AFMForce spectroscopyNanoindentationCancer cells motility |
| spellingShingle | A.V. Vakhrusheva A.V. Murashko E.S. Trifonova Yu.M. Efremov P.S. Timashev O.S. Sokolova Role of actin-binding proteins in the regulation of cellular mechanics European Journal of Cell Biology Actin-binding proteins Actin Cytoskeleton, AFM Force spectroscopy Nanoindentation Cancer cells motility |
| title | Role of actin-binding proteins in the regulation of cellular mechanics |
| title_full | Role of actin-binding proteins in the regulation of cellular mechanics |
| title_fullStr | Role of actin-binding proteins in the regulation of cellular mechanics |
| title_full_unstemmed | Role of actin-binding proteins in the regulation of cellular mechanics |
| title_short | Role of actin-binding proteins in the regulation of cellular mechanics |
| title_sort | role of actin binding proteins in the regulation of cellular mechanics |
| topic | Actin-binding proteins Actin Cytoskeleton, AFM Force spectroscopy Nanoindentation Cancer cells motility |
| url | http://www.sciencedirect.com/science/article/pii/S0171933522000449 |
| work_keys_str_mv | AT avvakhrusheva roleofactinbindingproteinsintheregulationofcellularmechanics AT avmurashko roleofactinbindingproteinsintheregulationofcellularmechanics AT estrifonova roleofactinbindingproteinsintheregulationofcellularmechanics AT yumefremov roleofactinbindingproteinsintheregulationofcellularmechanics AT pstimashev roleofactinbindingproteinsintheregulationofcellularmechanics AT ossokolova roleofactinbindingproteinsintheregulationofcellularmechanics |