Evolution-Informed Strategies for Combating Drug Resistance in Cancer
The ever-changing nature of cancer poses the most difficult challenge oncologists face today. Cancer’s remarkable adaptability has inspired many to work toward understanding the evolutionary dynamics that underlie this disease in hopes of learning new ways to fight it. Eco-evolutionary dynamics of a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/7/6738 |
| _version_ | 1797607765741404160 |
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| author | Kristi Lin-Rahardja Davis T. Weaver Jessica A. Scarborough Jacob G. Scott |
| author_facet | Kristi Lin-Rahardja Davis T. Weaver Jessica A. Scarborough Jacob G. Scott |
| author_sort | Kristi Lin-Rahardja |
| collection | DOAJ |
| description | The ever-changing nature of cancer poses the most difficult challenge oncologists face today. Cancer’s remarkable adaptability has inspired many to work toward understanding the evolutionary dynamics that underlie this disease in hopes of learning new ways to fight it. Eco-evolutionary dynamics of a tumor are not accounted for in most standard treatment regimens, but exploiting them would help us combat treatment-resistant effectively. Here, we outline several notable efforts to exploit these dynamics and circumvent drug resistance in cancer. |
| first_indexed | 2024-03-11T05:34:17Z |
| format | Article |
| id | doaj.art-ccc33ad1ac3f4225b268f351994915e4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:34:17Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ccc33ad1ac3f4225b268f351994915e42023-11-17T16:55:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01247673810.3390/ijms24076738Evolution-Informed Strategies for Combating Drug Resistance in CancerKristi Lin-Rahardja0Davis T. Weaver1Jessica A. Scarborough2Jacob G. Scott3Systems Biology & Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USASystems Biology & Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USASystems Biology & Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USASystems Biology & Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USAThe ever-changing nature of cancer poses the most difficult challenge oncologists face today. Cancer’s remarkable adaptability has inspired many to work toward understanding the evolutionary dynamics that underlie this disease in hopes of learning new ways to fight it. Eco-evolutionary dynamics of a tumor are not accounted for in most standard treatment regimens, but exploiting them would help us combat treatment-resistant effectively. Here, we outline several notable efforts to exploit these dynamics and circumvent drug resistance in cancer.https://www.mdpi.com/1422-0067/24/7/6738cancerdrug resistanceevolutionecology |
| spellingShingle | Kristi Lin-Rahardja Davis T. Weaver Jessica A. Scarborough Jacob G. Scott Evolution-Informed Strategies for Combating Drug Resistance in Cancer International Journal of Molecular Sciences cancer drug resistance evolution ecology |
| title | Evolution-Informed Strategies for Combating Drug Resistance in Cancer |
| title_full | Evolution-Informed Strategies for Combating Drug Resistance in Cancer |
| title_fullStr | Evolution-Informed Strategies for Combating Drug Resistance in Cancer |
| title_full_unstemmed | Evolution-Informed Strategies for Combating Drug Resistance in Cancer |
| title_short | Evolution-Informed Strategies for Combating Drug Resistance in Cancer |
| title_sort | evolution informed strategies for combating drug resistance in cancer |
| topic | cancer drug resistance evolution ecology |
| url | https://www.mdpi.com/1422-0067/24/7/6738 |
| work_keys_str_mv | AT kristilinrahardja evolutioninformedstrategiesforcombatingdrugresistanceincancer AT davistweaver evolutioninformedstrategiesforcombatingdrugresistanceincancer AT jessicaascarborough evolutioninformedstrategiesforcombatingdrugresistanceincancer AT jacobgscott evolutioninformedstrategiesforcombatingdrugresistanceincancer |