The potential of synthetic small interfering RNA-based antiviral drugs for influenza treatment
Influenza is a worldwide public health problem. Annually, this infection affects up to 15% of the world population; and about half a million people die from this disease every year. Moreover, influenza A and B viruses tend to garner most of the attention, as these types are a major cause of the epid...
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| Format: | Article |
| Language: | English |
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Central Research Institute for Epidemiology
2020-09-01
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| Series: | Вопросы вирусологии |
| Subjects: | |
| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/402/268 |
| _version_ | 1827903162589118464 |
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| author | E. A. Pashkov E. B. Faizuloev O. A. Svitich O. V. Sergeev V. V. Zverev |
| author_facet | E. A. Pashkov E. B. Faizuloev O. A. Svitich O. V. Sergeev V. V. Zverev |
| author_sort | E. A. Pashkov |
| collection | DOAJ |
| description | Influenza is a worldwide public health problem. Annually, this infection affects up to 15% of the world population; and about half a million people die from this disease every year. Moreover, influenza A and B viruses tend to garner most of the attention, as these types are a major cause of the epidemics and pandemics. Although the influenza virus primarily affects the respiratory tract, it may also affect the cardiovascular and central nervous systems. Several antiviral drugs, that target various stages of viral reproduction, have been considered effective for the treatment and prevention of influenza, but some virus strains become resistant to these medications. Thus, new strategies and techniques should be developed to overcome the antiviral drug resistance. Recent studies suggest that new drugs based on RNA interference (RNAi) appear to be a promising therapeutic approach that regulates the activity of viral or cellular genes. As it is known, the RNAi is a eukaryotic gene regulatory mechanism that can be triggered by a foreign double-stranded RNA (dsRNA) and results in the cleavage of the target messenger RNA (mRNA). This review discusses the prospects, advantages, and disadvantages of using RNAi in carrying out a specific treatment for influenza infection. However, some viruses confer resistance to small interfering RNAs (siRNA) targeting viral genes. This problem can significantly reduce the effectiveness of RNAi. Therefore, applying siRNAs targeting host cell factors required for influenza virus reproduction can be a way to overcome the antiviral drug resistance. |
| first_indexed | 2024-03-13T00:09:06Z |
| format | Article |
| id | doaj.art-ccc3b0b1128345c0a907000ab3a088f8 |
| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-13T00:09:06Z |
| publishDate | 2020-09-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj.art-ccc3b0b1128345c0a907000ab3a088f82023-07-12T19:57:33ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972020-09-0165418219010.36233/0507-4088-2020-65-4-182-190343The potential of synthetic small interfering RNA-based antiviral drugs for influenza treatmentE. A. Pashkov0https://orcid.org/0000-0002-5682-4581E. B. Faizuloev1https://orcid.org/0000-0001-7385-5083O. A. Svitich2https://orcid.org/0000-0003-1757-8389O. V. Sergeev3https://orcid.org/0000-0003-3407-2224V. V. Zverev4https://orcid.org/0000-0002-0017-1892I.M. Sechenov First Moscow State Medical University (Sechenov University)I.I. Mechnikov Research Institute for Vaccines and SeraI.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Influenza is a worldwide public health problem. Annually, this infection affects up to 15% of the world population; and about half a million people die from this disease every year. Moreover, influenza A and B viruses tend to garner most of the attention, as these types are a major cause of the epidemics and pandemics. Although the influenza virus primarily affects the respiratory tract, it may also affect the cardiovascular and central nervous systems. Several antiviral drugs, that target various stages of viral reproduction, have been considered effective for the treatment and prevention of influenza, but some virus strains become resistant to these medications. Thus, new strategies and techniques should be developed to overcome the antiviral drug resistance. Recent studies suggest that new drugs based on RNA interference (RNAi) appear to be a promising therapeutic approach that regulates the activity of viral or cellular genes. As it is known, the RNAi is a eukaryotic gene regulatory mechanism that can be triggered by a foreign double-stranded RNA (dsRNA) and results in the cleavage of the target messenger RNA (mRNA). This review discusses the prospects, advantages, and disadvantages of using RNAi in carrying out a specific treatment for influenza infection. However, some viruses confer resistance to small interfering RNAs (siRNA) targeting viral genes. This problem can significantly reduce the effectiveness of RNAi. Therefore, applying siRNAs targeting host cell factors required for influenza virus reproduction can be a way to overcome the antiviral drug resistance.https://virusjour.crie.ru/jour/article/viewFile/402/268influenzarna-interferencesmall interfering rnadrug resistanceinfluenza virus а and вgene knockdown |
| spellingShingle | E. A. Pashkov E. B. Faizuloev O. A. Svitich O. V. Sergeev V. V. Zverev The potential of synthetic small interfering RNA-based antiviral drugs for influenza treatment Вопросы вирусологии influenza rna-interference small interfering rna drug resistance influenza virus а and в gene knockdown |
| title | The potential of synthetic small interfering RNA-based antiviral drugs for influenza treatment |
| title_full | The potential of synthetic small interfering RNA-based antiviral drugs for influenza treatment |
| title_fullStr | The potential of synthetic small interfering RNA-based antiviral drugs for influenza treatment |
| title_full_unstemmed | The potential of synthetic small interfering RNA-based antiviral drugs for influenza treatment |
| title_short | The potential of synthetic small interfering RNA-based antiviral drugs for influenza treatment |
| title_sort | potential of synthetic small interfering rna based antiviral drugs for influenza treatment |
| topic | influenza rna-interference small interfering rna drug resistance influenza virus а and в gene knockdown |
| url | https://virusjour.crie.ru/jour/article/viewFile/402/268 |
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