The effects of fine particulate matter constituents on exhaled nitric oxide and DNA methylation in the arginase–nitric oxide synthase pathway
Background: Fine particulate matter (PM2.5) has been widely associated with airway inflammation represented by increased fractional concentration of exhaled nitric oxide (FeNO). However, it remains unclear whether various PM2.5 constituents have different impacts on FeNO and its production process f...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-10-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019309390 |
| _version_ | 1819093316504911872 |
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| author | Qingli Zhang Weidong Wang Yue Niu Yongjie Xia Xiaoning Lei Juntao Huo Qianbiao Zhao Yihua Zhang Yusen Duan Jing Cai Zhekang Ying Weihua Li Renjie Chen Qingyan Fu Haidong Kan |
| author_facet | Qingli Zhang Weidong Wang Yue Niu Yongjie Xia Xiaoning Lei Juntao Huo Qianbiao Zhao Yihua Zhang Yusen Duan Jing Cai Zhekang Ying Weihua Li Renjie Chen Qingyan Fu Haidong Kan |
| author_sort | Qingli Zhang |
| collection | DOAJ |
| description | Background: Fine particulate matter (PM2.5) has been widely associated with airway inflammation represented by increased fractional concentration of exhaled nitric oxide (FeNO). However, it remains unclear whether various PM2.5 constituents have different impacts on FeNO and its production process from the arginase (ARG)–nitric oxide synthase (NOS) pathway. Objectives: To investigate the acute effects of PM2.5 constituents on FeNO and DNA methylation of genes involved. Methods: We conducted a longitudinal panel study among 43 young adults in Shanghai, China from May to October in 2016. We monitored the concentrations of 25 constituents of PM2.5. We applied the linear mixed-effect model to evaluate the associations of PM2.5 constituents with FeNO and DNA methylation of the ARG2 and NOS2A genes. Results: Following PM2.5 exposure, NOS2A methylation decreased and ARG2 methylation increased only on the concurrent day, whereas FeNO increased most prominently on the second day. Nine constituents (OC, EC, K, Fe, Zn, Ba, Cr, Se, and Pb) showed consistent associations with elevated FeNO and decreased NOS2A methylation or increased ARG2 methylation in single-constituent models and models adjusting for PM2.5 total mass and collinearity. An interquartile range increase of these constituents was associated with respective decrements of 0.27–1.20 in NOS2A methylation (%5mC); increments of 0.48–1.56 in ARG2 methylation (%5mC); and increments of 7.12%–17.54% in FeNO. Conclusions: Our results suggested that OC, EC, and some metallic elements may be mainly responsible for the development and epigenetic regulation of airway inflammatory response induced by short-term PM2.5 exposure. Keywords: Fine particulate matter, Chemical constituents, Airway inflammation, Exhaled nitric oxide, DNA methylation, Panel study |
| first_indexed | 2024-12-21T23:09:35Z |
| format | Article |
| id | doaj.art-ccc3ee3e742c4032abdd79e21d186299 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-21T23:09:35Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-ccc3ee3e742c4032abdd79e21d1862992022-12-21T18:47:04ZengElsevierEnvironment International0160-41202019-10-01131The effects of fine particulate matter constituents on exhaled nitric oxide and DNA methylation in the arginase–nitric oxide synthase pathwayQingli Zhang0Weidong Wang1Yue Niu2Yongjie Xia3Xiaoning Lei4Juntao Huo5Qianbiao Zhao6Yihua Zhang7Yusen Duan8Jing Cai9Zhekang Ying10Weihua Li11Renjie Chen12Qingyan Fu13Haidong Kan14School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, ChinaShanghai Environmental Monitoring Center, Shanghai 200235, ChinaShanghai Environmental Monitoring Center, Shanghai 200235, ChinaShanghai Environmental Monitoring Center, Shanghai 200235, ChinaShanghai Environmental Monitoring Center, Shanghai 200235, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, ChinaKey Laboratory of Reproduction Regulation of National Population and Family Planning Commission, Shanghai Institute of Planned Parenthood Research, Institute of Reproduction and Development, Fudan University, Shanghai 200032, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Meteorology and Health, Shanghai 200030, China; Corresponding authors at: Department of Environmental Health, School of Public Health, Fudan University, P.O. Box 249, 130 Dong-An Road, Shanghai 200032, China.Shanghai Environmental Monitoring Center, Shanghai 200235, China; Correspondence to: Q. Fu, Shanghai Environmental Monitoring Center, 55 Sanjiang Road, Shanghai 200235, China.School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China; Key Laboratory of Reproduction Regulation of National Population and Family Planning Commission, Shanghai Institute of Planned Parenthood Research, Institute of Reproduction and Development, Fudan University, Shanghai 200032, China; Corresponding authors at: Department of Environmental Health, School of Public Health, Fudan University, P.O. Box 249, 130 Dong-An Road, Shanghai 200032, China.Background: Fine particulate matter (PM2.5) has been widely associated with airway inflammation represented by increased fractional concentration of exhaled nitric oxide (FeNO). However, it remains unclear whether various PM2.5 constituents have different impacts on FeNO and its production process from the arginase (ARG)–nitric oxide synthase (NOS) pathway. Objectives: To investigate the acute effects of PM2.5 constituents on FeNO and DNA methylation of genes involved. Methods: We conducted a longitudinal panel study among 43 young adults in Shanghai, China from May to October in 2016. We monitored the concentrations of 25 constituents of PM2.5. We applied the linear mixed-effect model to evaluate the associations of PM2.5 constituents with FeNO and DNA methylation of the ARG2 and NOS2A genes. Results: Following PM2.5 exposure, NOS2A methylation decreased and ARG2 methylation increased only on the concurrent day, whereas FeNO increased most prominently on the second day. Nine constituents (OC, EC, K, Fe, Zn, Ba, Cr, Se, and Pb) showed consistent associations with elevated FeNO and decreased NOS2A methylation or increased ARG2 methylation in single-constituent models and models adjusting for PM2.5 total mass and collinearity. An interquartile range increase of these constituents was associated with respective decrements of 0.27–1.20 in NOS2A methylation (%5mC); increments of 0.48–1.56 in ARG2 methylation (%5mC); and increments of 7.12%–17.54% in FeNO. Conclusions: Our results suggested that OC, EC, and some metallic elements may be mainly responsible for the development and epigenetic regulation of airway inflammatory response induced by short-term PM2.5 exposure. Keywords: Fine particulate matter, Chemical constituents, Airway inflammation, Exhaled nitric oxide, DNA methylation, Panel studyhttp://www.sciencedirect.com/science/article/pii/S0160412019309390 |
| spellingShingle | Qingli Zhang Weidong Wang Yue Niu Yongjie Xia Xiaoning Lei Juntao Huo Qianbiao Zhao Yihua Zhang Yusen Duan Jing Cai Zhekang Ying Weihua Li Renjie Chen Qingyan Fu Haidong Kan The effects of fine particulate matter constituents on exhaled nitric oxide and DNA methylation in the arginase–nitric oxide synthase pathway Environment International |
| title | The effects of fine particulate matter constituents on exhaled nitric oxide and DNA methylation in the arginase–nitric oxide synthase pathway |
| title_full | The effects of fine particulate matter constituents on exhaled nitric oxide and DNA methylation in the arginase–nitric oxide synthase pathway |
| title_fullStr | The effects of fine particulate matter constituents on exhaled nitric oxide and DNA methylation in the arginase–nitric oxide synthase pathway |
| title_full_unstemmed | The effects of fine particulate matter constituents on exhaled nitric oxide and DNA methylation in the arginase–nitric oxide synthase pathway |
| title_short | The effects of fine particulate matter constituents on exhaled nitric oxide and DNA methylation in the arginase–nitric oxide synthase pathway |
| title_sort | effects of fine particulate matter constituents on exhaled nitric oxide and dna methylation in the arginase nitric oxide synthase pathway |
| url | http://www.sciencedirect.com/science/article/pii/S0160412019309390 |
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