Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep Disorders
Objective: Older adults with sleep disorders (SDs) show impaired working memory abilities, and working memory processes are closely related to the prefrontal cortex (PFC). However, the neural mechanism of working memory impairment in older adults with SD remains unclear. This study aimed to investig...
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MDPI AG
2023-03-01
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| Online Access: | https://www.mdpi.com/2076-3425/13/3/497 |
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| author | Jiahui Gao Lin Zhang Jingfang Zhu Zhenxing Guo Miaoran Lin Linxin Bai Peiyun Zheng Weilin Liu Jia Huang Zhizhen Liu |
| author_facet | Jiahui Gao Lin Zhang Jingfang Zhu Zhenxing Guo Miaoran Lin Linxin Bai Peiyun Zheng Weilin Liu Jia Huang Zhizhen Liu |
| author_sort | Jiahui Gao |
| collection | DOAJ |
| description | Objective: Older adults with sleep disorders (SDs) show impaired working memory abilities, and working memory processes are closely related to the prefrontal cortex (PFC). However, the neural mechanism of working memory impairment in older adults with SD remains unclear. This study aimed to investigate changes in PFC function among older adults with SD when carrying out the N-back task by functional near-infrared spectroscopy (fNIRS). Method: A total of 37 older adults with SDs were enrolled in this study and matched with 37 healthy older adults by gender, age, and years of education. Changes in PFC function were observed by fNIRS when carrying out the N-back task. Results: The accuracy on the 0-back and 2-back tasks in the SD group was significantly lower than that in the healthy controls (HC) group. The oxygenated hemoglobin (oxy-Hb) concentration of channel 8 which located in the dorsolateral prefrontal cortex (DLPFC) was significantly reduced in the SD group during the 2-back task, and the channel-to-channel connectivity between the PFC subregions was significantly decreased. Conclusions: These results suggest that patients with sleep disorders have a weak performance of working memory; indeed, the activation and functional connectivity in the prefrontal subregions were reduced in this study. This may provide new evidence for working memory impairment and brain function changes in elderly SDs. |
| first_indexed | 2024-03-11T06:50:58Z |
| format | Article |
| id | doaj.art-ccc4388df7d141c58793408a744fd9e6 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T06:50:58Z |
| publishDate | 2023-03-01 |
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| series | Brain Sciences |
| spelling | doaj.art-ccc4388df7d141c58793408a744fd9e62023-11-17T10:00:40ZengMDPI AGBrain Sciences2076-34252023-03-0113349710.3390/brainsci13030497Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep DisordersJiahui Gao0Lin Zhang1Jingfang Zhu2Zhenxing Guo3Miaoran Lin4Linxin Bai5Peiyun Zheng6Weilin Liu7Jia Huang8Zhizhen Liu9College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, ChinaObjective: Older adults with sleep disorders (SDs) show impaired working memory abilities, and working memory processes are closely related to the prefrontal cortex (PFC). However, the neural mechanism of working memory impairment in older adults with SD remains unclear. This study aimed to investigate changes in PFC function among older adults with SD when carrying out the N-back task by functional near-infrared spectroscopy (fNIRS). Method: A total of 37 older adults with SDs were enrolled in this study and matched with 37 healthy older adults by gender, age, and years of education. Changes in PFC function were observed by fNIRS when carrying out the N-back task. Results: The accuracy on the 0-back and 2-back tasks in the SD group was significantly lower than that in the healthy controls (HC) group. The oxygenated hemoglobin (oxy-Hb) concentration of channel 8 which located in the dorsolateral prefrontal cortex (DLPFC) was significantly reduced in the SD group during the 2-back task, and the channel-to-channel connectivity between the PFC subregions was significantly decreased. Conclusions: These results suggest that patients with sleep disorders have a weak performance of working memory; indeed, the activation and functional connectivity in the prefrontal subregions were reduced in this study. This may provide new evidence for working memory impairment and brain function changes in elderly SDs.https://www.mdpi.com/2076-3425/13/3/497working memoryfunctional near-infrared spectroscopysleep disordersfunctional connectivityhemodynamicprefrontal cortex |
| spellingShingle | Jiahui Gao Lin Zhang Jingfang Zhu Zhenxing Guo Miaoran Lin Linxin Bai Peiyun Zheng Weilin Liu Jia Huang Zhizhen Liu Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep Disorders Brain Sciences working memory functional near-infrared spectroscopy sleep disorders functional connectivity hemodynamic prefrontal cortex |
| title | Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep Disorders |
| title_full | Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep Disorders |
| title_fullStr | Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep Disorders |
| title_full_unstemmed | Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep Disorders |
| title_short | Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep Disorders |
| title_sort | prefrontal cortex hemodynamics and functional connectivity changes during performance working memory tasks in older adults with sleep disorders |
| topic | working memory functional near-infrared spectroscopy sleep disorders functional connectivity hemodynamic prefrontal cortex |
| url | https://www.mdpi.com/2076-3425/13/3/497 |
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