The time to trade-off method versus the EQ-5D index to determine health utility in patients with rheumatoid arthritis
Clinicoeconomic studies require that the health utility index be used to calculate quality-adjusted life years (QALY). Choice of an adequate method for determining health utility for patients with rheumatoid arthritis (RA) makes it necessary to compare various approaches to this assessment. Objectiv...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2010-12-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/962 |
| _version_ | 1797862877428711424 |
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| author | Dmitriy Vladimirovich Goryachev Sh F Erdes Dmitry Vladimirovich Goryachev Sh F Erdes |
| author_facet | Dmitriy Vladimirovich Goryachev Sh F Erdes Dmitry Vladimirovich Goryachev Sh F Erdes |
| author_sort | Dmitriy Vladimirovich Goryachev |
| collection | DOAJ |
| description | Clinicoeconomic studies require that the health utility index be used to calculate quality-adjusted life years (QALY). Choice of an adequate method for determining health utility for patients with rheumatoid arthritis (RA) makes it necessary to compare various approaches to this assessment. Objective. To compare health utility values obtained with a time to trade-off (TTO) method and those with the EQ-5D questionnaire. Subjects and methods. A single interview was made in 45 patients with RA (mean RA duration 11.7±6.6 years) with a mean HAQ of 1.22±0.52. Utility was assessed using the direct TTO method, EQ-5D index, and visual analogue scale of general health (VAS-GH); functional disease activity index was assessed according to the Health Assessment Questionnaire (HAQ). Results. Five (11.2%) patients with RA could not answer a question to calculate TTO. The mean TTO, EQ-5D, and VAS-GH "thermometer" indices were 0.55±0.36, 0.30±0.32, and 0.47±0.23, respectively. Conversion from EQ-5D to utility index yielded the values similar to those with a mean TTO of 0.54±0.29. The values of the utility index calculated by TTO failed to correlate with those of HAQ and EQ-5D. The disease duration was unrelated to the values of the utility index calculated by any of the methods used. The association of TTO index was found only for VAS-GH "thermometer". Conclusion. EQ-5D index and VAS-GH are the methods of choice in determining health utility for a clinicoeconomic analysis in patients with RA. |
| first_indexed | 2024-04-09T22:26:37Z |
| format | Article |
| id | doaj.art-ccc4c346ad8a409889234843930c094d |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:26:37Z |
| publishDate | 2010-12-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-ccc4c346ad8a409889234843930c094d2023-03-22T13:45:46ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922010-12-01486868910.14412/1995-4484-2010-829902The time to trade-off method versus the EQ-5D index to determine health utility in patients with rheumatoid arthritisDmitriy Vladimirovich GoryachevSh F ErdesDmitry Vladimirovich GoryachevSh F ErdesClinicoeconomic studies require that the health utility index be used to calculate quality-adjusted life years (QALY). Choice of an adequate method for determining health utility for patients with rheumatoid arthritis (RA) makes it necessary to compare various approaches to this assessment. Objective. To compare health utility values obtained with a time to trade-off (TTO) method and those with the EQ-5D questionnaire. Subjects and methods. A single interview was made in 45 patients with RA (mean RA duration 11.7±6.6 years) with a mean HAQ of 1.22±0.52. Utility was assessed using the direct TTO method, EQ-5D index, and visual analogue scale of general health (VAS-GH); functional disease activity index was assessed according to the Health Assessment Questionnaire (HAQ). Results. Five (11.2%) patients with RA could not answer a question to calculate TTO. The mean TTO, EQ-5D, and VAS-GH "thermometer" indices were 0.55±0.36, 0.30±0.32, and 0.47±0.23, respectively. Conversion from EQ-5D to utility index yielded the values similar to those with a mean TTO of 0.54±0.29. The values of the utility index calculated by TTO failed to correlate with those of HAQ and EQ-5D. The disease duration was unrelated to the values of the utility index calculated by any of the methods used. The association of TTO index was found only for VAS-GH "thermometer". Conclusion. EQ-5D index and VAS-GH are the methods of choice in determining health utility for a clinicoeconomic analysis in patients with RA.https://rsp.mediar-press.net/rsp/article/view/962eq-5drheumatoid arthritisutility indexeq-5dtime to trade-off method (tto) |
| spellingShingle | Dmitriy Vladimirovich Goryachev Sh F Erdes Dmitry Vladimirovich Goryachev Sh F Erdes The time to trade-off method versus the EQ-5D index to determine health utility in patients with rheumatoid arthritis Научно-практическая ревматология eq-5d rheumatoid arthritis utility index eq-5d time to trade-off method (tto) |
| title | The time to trade-off method versus the EQ-5D index to determine health utility in patients with rheumatoid arthritis |
| title_full | The time to trade-off method versus the EQ-5D index to determine health utility in patients with rheumatoid arthritis |
| title_fullStr | The time to trade-off method versus the EQ-5D index to determine health utility in patients with rheumatoid arthritis |
| title_full_unstemmed | The time to trade-off method versus the EQ-5D index to determine health utility in patients with rheumatoid arthritis |
| title_short | The time to trade-off method versus the EQ-5D index to determine health utility in patients with rheumatoid arthritis |
| title_sort | time to trade off method versus the eq 5d index to determine health utility in patients with rheumatoid arthritis |
| topic | eq-5d rheumatoid arthritis utility index eq-5d time to trade-off method (tto) |
| url | https://rsp.mediar-press.net/rsp/article/view/962 |
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