Probiotic cheese improves alcohol metabolism and alleviates alcohol-induced liver injury via the SIRT1/AMPK signaling pathway
Excessive alcohol intake leads to alcoholic liver injury via hepatic acetaldehyde accumulation. Some probiotic bacteria, such as Lactiplantibacillus plantarum and Bifidobacterium, are known to have the ability to break down acetaldehyde; however, there is a lack of evidence on their efficacy in func...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623003365 |
| _version_ | 1797688993432731648 |
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| author | Jong-Hwa Kim Dohyun Woo YoHan Nam Jihye Baek Ji-Yeon Lee Wonyong Kim |
| author_facet | Jong-Hwa Kim Dohyun Woo YoHan Nam Jihye Baek Ji-Yeon Lee Wonyong Kim |
| author_sort | Jong-Hwa Kim |
| collection | DOAJ |
| description | Excessive alcohol intake leads to alcoholic liver injury via hepatic acetaldehyde accumulation. Some probiotic bacteria, such as Lactiplantibacillus plantarum and Bifidobacterium, are known to have the ability to break down acetaldehyde; however, there is a lack of evidence on their efficacy in functional food applications. In this study, probiotic cheese containing Lactococcus lactis LB1022 and Lactiplantibacillus plantarum LB1418 was evaluated for its function in inducing alcohol metabolism and alleviating alcohol-induced hepatic injury. Probiotic cheese ameliorated alcohol metabolism induced by alcohol dehydrogenase and aldehyde dehydrogenase, enhanced the sirtuin-1 (SIRT1)/adenosine monophosphate-activated protein kinase (AMPK) signaling, and inhibited the nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway. Interestingly, probiotic cheese also induced peroxisome proliferator-activated receptor α and prevented fat formation and inflammation in the liver. Taken together, probiotic cheese containing Lc. lactis LB1022 and Lb. plantarum LB1418 could induce alcohol metabolism and alleviate alcohol-induced liver injury by regulating SIRT1 in fatty acid oxidation, AMPK in lipogenesis, and NF-κB in inflammation. |
| first_indexed | 2024-03-12T01:38:32Z |
| format | Article |
| id | doaj.art-ccc79249c9ba4cadab4a6a92e7724af3 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T01:38:32Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-ccc79249c9ba4cadab4a6a92e7724af32023-09-11T04:16:51ZengElsevierJournal of Functional Foods1756-46462023-09-01108105736Probiotic cheese improves alcohol metabolism and alleviates alcohol-induced liver injury via the SIRT1/AMPK signaling pathwayJong-Hwa Kim0Dohyun Woo1YoHan Nam2Jihye Baek3Ji-Yeon Lee4Wonyong Kim5Department of Microbiology, Chung-Ang University College of Medicine, Seoul 06974, Republic of KoreaDepartment of Anesthesiology and Critical Care Medicine, Pain Management, Korea Cancer Center Hospital, Seoul 01812, Republic of KoreaDepartment of Microbiology, Chung-Ang University College of Medicine, Seoul 06974, Republic of KoreaDepartment of Microbiology, Chung-Ang University College of Medicine, Seoul 06974, Republic of KoreaDepartment of Anesthesiology and Critical Care Medicine, Pain Management, Korea Cancer Center Hospital, Seoul 01812, Republic of KoreaDepartment of Microbiology, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea; LuxBiome Co., Ltd., Seoul 06974, Republic of Korea.; Corresponding author at: Department of Microbiology, Chung-Ang University College of Medicine, 84, Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.Excessive alcohol intake leads to alcoholic liver injury via hepatic acetaldehyde accumulation. Some probiotic bacteria, such as Lactiplantibacillus plantarum and Bifidobacterium, are known to have the ability to break down acetaldehyde; however, there is a lack of evidence on their efficacy in functional food applications. In this study, probiotic cheese containing Lactococcus lactis LB1022 and Lactiplantibacillus plantarum LB1418 was evaluated for its function in inducing alcohol metabolism and alleviating alcohol-induced hepatic injury. Probiotic cheese ameliorated alcohol metabolism induced by alcohol dehydrogenase and aldehyde dehydrogenase, enhanced the sirtuin-1 (SIRT1)/adenosine monophosphate-activated protein kinase (AMPK) signaling, and inhibited the nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway. Interestingly, probiotic cheese also induced peroxisome proliferator-activated receptor α and prevented fat formation and inflammation in the liver. Taken together, probiotic cheese containing Lc. lactis LB1022 and Lb. plantarum LB1418 could induce alcohol metabolism and alleviate alcohol-induced liver injury by regulating SIRT1 in fatty acid oxidation, AMPK in lipogenesis, and NF-κB in inflammation.http://www.sciencedirect.com/science/article/pii/S1756464623003365Probiotic cheeseAlcoholAMPKSIRT1NF-κB. PPARα |
| spellingShingle | Jong-Hwa Kim Dohyun Woo YoHan Nam Jihye Baek Ji-Yeon Lee Wonyong Kim Probiotic cheese improves alcohol metabolism and alleviates alcohol-induced liver injury via the SIRT1/AMPK signaling pathway Journal of Functional Foods Probiotic cheese Alcohol AMPK SIRT1 NF-κB. PPARα |
| title | Probiotic cheese improves alcohol metabolism and alleviates alcohol-induced liver injury via the SIRT1/AMPK signaling pathway |
| title_full | Probiotic cheese improves alcohol metabolism and alleviates alcohol-induced liver injury via the SIRT1/AMPK signaling pathway |
| title_fullStr | Probiotic cheese improves alcohol metabolism and alleviates alcohol-induced liver injury via the SIRT1/AMPK signaling pathway |
| title_full_unstemmed | Probiotic cheese improves alcohol metabolism and alleviates alcohol-induced liver injury via the SIRT1/AMPK signaling pathway |
| title_short | Probiotic cheese improves alcohol metabolism and alleviates alcohol-induced liver injury via the SIRT1/AMPK signaling pathway |
| title_sort | probiotic cheese improves alcohol metabolism and alleviates alcohol induced liver injury via the sirt1 ampk signaling pathway |
| topic | Probiotic cheese Alcohol AMPK SIRT1 NF-κB. PPARα |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623003365 |
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