Association between metabolic syndrome and body constitution of traditional Chinese medicine: A systematic review and meta-analysis
Background: The constitution theory of traditional Chinese medicine (TCM) states that body constitution and disease are associated; therefore, the identification of body constitution can provide reference for disease prevention and treatment. A series of clinical studies evaluating the association b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Journal of Traditional Chinese Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095754820300934 |
| _version_ | 1797718981745836032 |
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| author | Hui Luo Lingru Li Tianxing Li Xing Liao Qi Wang |
| author_facet | Hui Luo Lingru Li Tianxing Li Xing Liao Qi Wang |
| author_sort | Hui Luo |
| collection | DOAJ |
| description | Background: The constitution theory of traditional Chinese medicine (TCM) states that body constitution and disease are associated; therefore, the identification of body constitution can provide reference for disease prevention and treatment. A series of clinical studies evaluating the association between TCM constitution and metabolic syndrome (MetS) have been conducted in recent years. The aim of this systematic review is to summarize and evaluate the clinical evidence of the relationship between constitution and MetS. Methods: The PubMed, Embase, China National Knowledge Infrastructure (CNKI), Chongqing VIP, and Wanfang Data electronic databases were searched from April 2009 to July 2020. The search terms included “metabolic syndrome,” “constitution,” and “Chinese medicine.” Observational studies evaluating the relationship between body constitution of TCM and MetS were included. The primary outcome included the distribution of constitutional types in the MetS population, and odds ratio (OR) or relative risk (RR) between constitution and MetS. Effect size was expressed as proportion or OR with 95% confidence interval (CI). Methodological quality of included studies was evaluated by the Newcastle–Ottawa Scale (NOS) or the American Agency for Healthcare Research and Quality (AHRQ) criteria. Results: Three case–control and 26 cross-sectional studies involving 30 435 cases were included. Phlegm-dampness, qi-deficiency, and damp-heat were the main constitution types in patients with MetS, accounting for 29% (22%–39%), 18% (13%–24%), and 12% (9%–17%) of the population, respectively; the risk of MetS in people with phlegm-dampness and qi-deficiency constitution was 1.74 [1.27, 2.38] and 1.29 [1.01, 1.65] times higher than that in those with other constitutions. There were sex- and age-related differences in the distribution of TCM constitution in patients with MetS. Conclusion: Phlegm-dampness and qi-deficiency were associated with the occurrence of MetS. Well-designed cohort and case–control studies are needed to provide evidence for the use of TCM to prevent and treat MetS. |
| first_indexed | 2024-03-12T08:58:08Z |
| format | Article |
| id | doaj.art-ccc79c5ce43b4d7b8515a6712677901d |
| institution | Directory Open Access Journal |
| issn | 2095-7548 |
| language | English |
| last_indexed | 2024-03-12T08:58:08Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional Chinese Medical Sciences |
| spelling | doaj.art-ccc79c5ce43b4d7b8515a6712677901d2023-09-02T15:52:33ZengElsevierJournal of Traditional Chinese Medical Sciences2095-75482020-12-0174355365Association between metabolic syndrome and body constitution of traditional Chinese medicine: A systematic review and meta-analysisHui Luo0Lingru Li1Tianxing Li2Xing Liao3Qi Wang4Institute for Tibetan Medicine, China Tibetology Research Center, Beijing 100101, China; Center for Studies in Constitution Research of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, ChinaCenter for Studies in Constitution Research of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, ChinaCenter for Studies in Constitution Research of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, ChinaCenter of Evidence Based Traditional Chinese Medicine, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaCenter for Studies in Constitution Research of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China; Corresponding author.Background: The constitution theory of traditional Chinese medicine (TCM) states that body constitution and disease are associated; therefore, the identification of body constitution can provide reference for disease prevention and treatment. A series of clinical studies evaluating the association between TCM constitution and metabolic syndrome (MetS) have been conducted in recent years. The aim of this systematic review is to summarize and evaluate the clinical evidence of the relationship between constitution and MetS. Methods: The PubMed, Embase, China National Knowledge Infrastructure (CNKI), Chongqing VIP, and Wanfang Data electronic databases were searched from April 2009 to July 2020. The search terms included “metabolic syndrome,” “constitution,” and “Chinese medicine.” Observational studies evaluating the relationship between body constitution of TCM and MetS were included. The primary outcome included the distribution of constitutional types in the MetS population, and odds ratio (OR) or relative risk (RR) between constitution and MetS. Effect size was expressed as proportion or OR with 95% confidence interval (CI). Methodological quality of included studies was evaluated by the Newcastle–Ottawa Scale (NOS) or the American Agency for Healthcare Research and Quality (AHRQ) criteria. Results: Three case–control and 26 cross-sectional studies involving 30 435 cases were included. Phlegm-dampness, qi-deficiency, and damp-heat were the main constitution types in patients with MetS, accounting for 29% (22%–39%), 18% (13%–24%), and 12% (9%–17%) of the population, respectively; the risk of MetS in people with phlegm-dampness and qi-deficiency constitution was 1.74 [1.27, 2.38] and 1.29 [1.01, 1.65] times higher than that in those with other constitutions. There were sex- and age-related differences in the distribution of TCM constitution in patients with MetS. Conclusion: Phlegm-dampness and qi-deficiency were associated with the occurrence of MetS. Well-designed cohort and case–control studies are needed to provide evidence for the use of TCM to prevent and treat MetS.http://www.sciencedirect.com/science/article/pii/S2095754820300934Body constitutionTraditional Chinese medicineMetabolic syndromeAssociationMeta-analysis |
| spellingShingle | Hui Luo Lingru Li Tianxing Li Xing Liao Qi Wang Association between metabolic syndrome and body constitution of traditional Chinese medicine: A systematic review and meta-analysis Journal of Traditional Chinese Medical Sciences Body constitution Traditional Chinese medicine Metabolic syndrome Association Meta-analysis |
| title | Association between metabolic syndrome and body constitution of traditional Chinese medicine: A systematic review and meta-analysis |
| title_full | Association between metabolic syndrome and body constitution of traditional Chinese medicine: A systematic review and meta-analysis |
| title_fullStr | Association between metabolic syndrome and body constitution of traditional Chinese medicine: A systematic review and meta-analysis |
| title_full_unstemmed | Association between metabolic syndrome and body constitution of traditional Chinese medicine: A systematic review and meta-analysis |
| title_short | Association between metabolic syndrome and body constitution of traditional Chinese medicine: A systematic review and meta-analysis |
| title_sort | association between metabolic syndrome and body constitution of traditional chinese medicine a systematic review and meta analysis |
| topic | Body constitution Traditional Chinese medicine Metabolic syndrome Association Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2095754820300934 |
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