Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis
The role of both cannabis use and genetic background has been shown in the risk for psychosis. However, the effect of the interplay between cannabis and variability at the endocannabinoid receptor genes on the neurobiological underpinnings of psychosis remains inconclusive. Through a case-only desig...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7501 |
| _version_ | 1797605040388571136 |
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| author | Maitane Oscoz-Irurozqui Carmen Almodóvar-Payá Maria Guardiola-Ripoll Amalia Guerrero-Pedraza Noemí Hostalet Raymond Salvador Maria Isabel Carrión Teresa Maristany Edith Pomarol-Clotet Mar Fatjó-Vilas |
| author_facet | Maitane Oscoz-Irurozqui Carmen Almodóvar-Payá Maria Guardiola-Ripoll Amalia Guerrero-Pedraza Noemí Hostalet Raymond Salvador Maria Isabel Carrión Teresa Maristany Edith Pomarol-Clotet Mar Fatjó-Vilas |
| author_sort | Maitane Oscoz-Irurozqui |
| collection | DOAJ |
| description | The role of both cannabis use and genetic background has been shown in the risk for psychosis. However, the effect of the interplay between cannabis and variability at the endocannabinoid receptor genes on the neurobiological underpinnings of psychosis remains inconclusive. Through a case-only design, including patients with a first-episode of psychosis (n = 40) classified as cannabis users (50%) and non-users (50%), we aimed to evaluate the interaction between cannabis use and common genetic variants at the endocannabinoid receptor genes on brain activity. Genetic variability was assessed by genotyping two Single Nucleotide Polymorphisms (SNP) at the cannabinoid receptor type 1 gene (<i>CNR1</i>; rs1049353) and cannabinoid receptor type 2 gene <i>(CNR2</i>; rs2501431). Functional Magnetic Resonance Imaging (fMRI) data were obtained while performing the n-back task. Gene × cannabis interaction models evidenced a combined effect of <i>CNR1</i> and <i>CNR2</i> genotypes and cannabis use on brain activity in different brain areas, such as the caudate nucleus, the cingulate cortex and the orbitofrontal cortex. These findings suggest a joint role of cannabis use and cannabinoid receptor genetic background on brain function in first-episode psychosis, possibly through the impact on brain areas relevant to the reward circuit. |
| first_indexed | 2024-03-11T04:55:28Z |
| format | Article |
| id | doaj.art-ccc80697d35d444e972d224572aeb6c9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:55:28Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ccc80697d35d444e972d224572aeb6c92023-11-17T19:41:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248750110.3390/ijms24087501Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode PsychosisMaitane Oscoz-Irurozqui0Carmen Almodóvar-Payá1Maria Guardiola-Ripoll2Amalia Guerrero-Pedraza3Noemí Hostalet4Raymond Salvador5Maria Isabel Carrión6Teresa Maristany7Edith Pomarol-Clotet8Mar Fatjó-Vilas9FIDMAG Germanes Hospitalàries Research Foundation, Av Jordà 8, 08035 Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Av Jordà 8, 08035 Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Av Jordà 8, 08035 Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Av Jordà 8, 08035 Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Av Jordà 8, 08035 Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Av Jordà 8, 08035 Barcelona, SpainHospital Sant Rafael, Passeig de la Vall d’Hebron, 107, 08035 Barcelona, SpainDiagnostic Imaging Department, Hospital Sant Joan de Déu Research Foundation, Passeig de Sant Joan de Déu, 2, 08950 Esplugues de Llobregat, Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Av Jordà 8, 08035 Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Av Jordà 8, 08035 Barcelona, SpainThe role of both cannabis use and genetic background has been shown in the risk for psychosis. However, the effect of the interplay between cannabis and variability at the endocannabinoid receptor genes on the neurobiological underpinnings of psychosis remains inconclusive. Through a case-only design, including patients with a first-episode of psychosis (n = 40) classified as cannabis users (50%) and non-users (50%), we aimed to evaluate the interaction between cannabis use and common genetic variants at the endocannabinoid receptor genes on brain activity. Genetic variability was assessed by genotyping two Single Nucleotide Polymorphisms (SNP) at the cannabinoid receptor type 1 gene (<i>CNR1</i>; rs1049353) and cannabinoid receptor type 2 gene <i>(CNR2</i>; rs2501431). Functional Magnetic Resonance Imaging (fMRI) data were obtained while performing the n-back task. Gene × cannabis interaction models evidenced a combined effect of <i>CNR1</i> and <i>CNR2</i> genotypes and cannabis use on brain activity in different brain areas, such as the caudate nucleus, the cingulate cortex and the orbitofrontal cortex. These findings suggest a joint role of cannabis use and cannabinoid receptor genetic background on brain function in first-episode psychosis, possibly through the impact on brain areas relevant to the reward circuit.https://www.mdpi.com/1422-0067/24/8/7501first-episode of psychosiscannabis usecannabinoid receptor genesfMRI working memory |
| spellingShingle | Maitane Oscoz-Irurozqui Carmen Almodóvar-Payá Maria Guardiola-Ripoll Amalia Guerrero-Pedraza Noemí Hostalet Raymond Salvador Maria Isabel Carrión Teresa Maristany Edith Pomarol-Clotet Mar Fatjó-Vilas Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis International Journal of Molecular Sciences first-episode of psychosis cannabis use cannabinoid receptor genes fMRI working memory |
| title | Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis |
| title_full | Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis |
| title_fullStr | Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis |
| title_full_unstemmed | Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis |
| title_short | Cannabis Use and Endocannabinoid Receptor Genes: A Pilot Study on Their Interaction on Brain Activity in First-Episode Psychosis |
| title_sort | cannabis use and endocannabinoid receptor genes a pilot study on their interaction on brain activity in first episode psychosis |
| topic | first-episode of psychosis cannabis use cannabinoid receptor genes fMRI working memory |
| url | https://www.mdpi.com/1422-0067/24/8/7501 |
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