Comparative efficacy and safety of intravenous tramadol and nalbuphine for pain relief in postoperative patients
Aim: To compare the efficacy and safety of single-dose intravenous nalbuphine versus intravenous tramadol for postoperative analgesia. Materials and Methods: In this prospective randomized study, adults with the American Society of Anesthesiologists physical status class I and II undergoing elective...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Indian Journal of Pain |
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| Online Access: | http://www.indianjpain.org/article.asp?issn=0970-5333;year=2018;volume=32;issue=2;spage=96;epage=101;aulast=Kiran |
| _version_ | 1811279502578286592 |
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| author | K Sai Durga Krishna Kiran Varsha Vyas Surekha Patil |
| author_facet | K Sai Durga Krishna Kiran Varsha Vyas Surekha Patil |
| author_sort | K Sai Durga Krishna Kiran |
| collection | DOAJ |
| description | Aim: To compare the efficacy and safety of single-dose intravenous nalbuphine versus intravenous tramadol for postoperative analgesia. Materials and Methods: In this prospective randomized study, adults with the American Society of Anesthesiologists physical status class I and II undergoing elective surgeries performed under general anesthesia, resulting in mild-to-moderate pain (n = 60), received either intravenous nalbuphine (10 mg) or tramadol (100 mg). Visual analog scale scores for pain, sedation, and nausea and vomiting were monitored for 4 h and compared between the two groups. Statistical Analysis: The mean scores within the groups were analyzed by paired t-test, whereas between the groups by unpaired t-test. The median scores were analyzed by using Mann–Whitney U test. P value <0.05 was considered statistically significant. Results: Reduction in pain after drug administration was statistically significant at all-time points as compared to before administration in both groups (P < 0.5). Pain reduction after 5 min (P = 0.01) and 30 min (P = 0.03) was significantly better with tramadol, whereas after 4 h, it was better with nalbuphine (P < 0.05). Incidence of nausea and vomiting in tramadol and nalbuphine groups was 23.3% and 40%, respectively. No statistically significant difference was observed in sedation, nausea, and vomiting scores between two groups at any time point (P > 0.05). Conclusion: Intravenous nalbuphine and tramadol both provided effective pain relief in patients with postoperative pain. Tramadol resulted in early pain relief but higher incidence of nausea and vomiting. |
| first_indexed | 2024-04-13T00:55:55Z |
| format | Article |
| id | doaj.art-ccca8aba8b4a4e3db538b264ea38fd78 |
| institution | Directory Open Access Journal |
| issn | 0970-5333 |
| language | English |
| last_indexed | 2024-04-13T00:55:55Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pain |
| spelling | doaj.art-ccca8aba8b4a4e3db538b264ea38fd782022-12-22T03:09:40ZengWolters Kluwer Medknow PublicationsIndian Journal of Pain0970-53332018-01-013229610110.4103/ijpn.ijpn_40_18Comparative efficacy and safety of intravenous tramadol and nalbuphine for pain relief in postoperative patientsK Sai Durga Krishna KiranVarsha VyasSurekha PatilAim: To compare the efficacy and safety of single-dose intravenous nalbuphine versus intravenous tramadol for postoperative analgesia. Materials and Methods: In this prospective randomized study, adults with the American Society of Anesthesiologists physical status class I and II undergoing elective surgeries performed under general anesthesia, resulting in mild-to-moderate pain (n = 60), received either intravenous nalbuphine (10 mg) or tramadol (100 mg). Visual analog scale scores for pain, sedation, and nausea and vomiting were monitored for 4 h and compared between the two groups. Statistical Analysis: The mean scores within the groups were analyzed by paired t-test, whereas between the groups by unpaired t-test. The median scores were analyzed by using Mann–Whitney U test. P value <0.05 was considered statistically significant. Results: Reduction in pain after drug administration was statistically significant at all-time points as compared to before administration in both groups (P < 0.5). Pain reduction after 5 min (P = 0.01) and 30 min (P = 0.03) was significantly better with tramadol, whereas after 4 h, it was better with nalbuphine (P < 0.05). Incidence of nausea and vomiting in tramadol and nalbuphine groups was 23.3% and 40%, respectively. No statistically significant difference was observed in sedation, nausea, and vomiting scores between two groups at any time point (P > 0.05). Conclusion: Intravenous nalbuphine and tramadol both provided effective pain relief in patients with postoperative pain. Tramadol resulted in early pain relief but higher incidence of nausea and vomiting.http://www.indianjpain.org/article.asp?issn=0970-5333;year=2018;volume=32;issue=2;spage=96;epage=101;aulast=KiranNalbuphinenauseapostoperative analgesiasedationtramadol |
| spellingShingle | K Sai Durga Krishna Kiran Varsha Vyas Surekha Patil Comparative efficacy and safety of intravenous tramadol and nalbuphine for pain relief in postoperative patients Indian Journal of Pain Nalbuphine nausea postoperative analgesia sedation tramadol |
| title | Comparative efficacy and safety of intravenous tramadol and nalbuphine for pain relief in postoperative patients |
| title_full | Comparative efficacy and safety of intravenous tramadol and nalbuphine for pain relief in postoperative patients |
| title_fullStr | Comparative efficacy and safety of intravenous tramadol and nalbuphine for pain relief in postoperative patients |
| title_full_unstemmed | Comparative efficacy and safety of intravenous tramadol and nalbuphine for pain relief in postoperative patients |
| title_short | Comparative efficacy and safety of intravenous tramadol and nalbuphine for pain relief in postoperative patients |
| title_sort | comparative efficacy and safety of intravenous tramadol and nalbuphine for pain relief in postoperative patients |
| topic | Nalbuphine nausea postoperative analgesia sedation tramadol |
| url | http://www.indianjpain.org/article.asp?issn=0970-5333;year=2018;volume=32;issue=2;spage=96;epage=101;aulast=Kiran |
| work_keys_str_mv | AT ksaidurgakrishnakiran comparativeefficacyandsafetyofintravenoustramadolandnalbuphineforpainreliefinpostoperativepatients AT varshavyas comparativeefficacyandsafetyofintravenoustramadolandnalbuphineforpainreliefinpostoperativepatients AT surekhapatil comparativeefficacyandsafetyofintravenoustramadolandnalbuphineforpainreliefinpostoperativepatients |