Colistin administration for extensive drug-resistant Pseudomonas aeruginosa pneumonia in intensive care unit: case report
Pseudomonas aeruginosa strains may develop the resistance to antibiotics via different mechanisms such as, alteration of protein binders of penicillin, porin mutations, DNA-gyrase mutation and active expulsion pumps. Especially, multi-drug resistant P.aeruginosa strains, are known to be most importa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cukurova University
2016-03-01
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| Series: | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | http://www.scopemed.org/fulltextpdf.php?mno=200841 |
| _version_ | 1797922206094721024 |
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| author | Cetin Kilinc Kemal Turker Ulutas Beril Akcimen Levent Celik Nizami Duran |
| author_facet | Cetin Kilinc Kemal Turker Ulutas Beril Akcimen Levent Celik Nizami Duran |
| author_sort | Cetin Kilinc |
| collection | DOAJ |
| description | Pseudomonas aeruginosa strains may develop the resistance to antibiotics via different mechanisms such as, alteration of protein binders of penicillin, porin mutations, DNA-gyrase mutation and active expulsion pumps. Especially, multi-drug resistant P.aeruginosa strains, are known to be most important cause of mortality in the intensive care units. Special antibiotic therapy is required, because of having the multiple antibiotic resistances. The case reports a 67-year-old male patient who had a history of 6 years paraplegia. He admitted to the emergency department with impaired general condition, including a week ongoing nausea,chest pain, cough, phlegm, wheezing and fatigue. Widespread crepitant rales were detected up to the middle and lower zones of both lungs. Besides, there was CRP elevation, hyperuricemia, a consolidated infiltration compatible with increased opacity at lower zone of right lung and reticulonodular style increased opacity at upper zone of right lung on chest .On disk diffusion, there was resistance to all antibiotics except colistin. Although colistin treatment was initiated, the patient was lost due to cardiac arrest at the 3rd day of treatment. This case is reported to be observed for the first time of P. aeruginosa infection that was extensively drug-resistant to antibiotics except colistin in our hospital, and to highlight importance of true treatment arrangements according to antibiotic susceptibility. [Cukurova Med J 2016; 41(1.000): 178-182] |
| first_indexed | 2024-04-10T14:27:48Z |
| format | Article |
| id | doaj.art-ccccae16661b485dbfebf7e4bf8fe416 |
| institution | Directory Open Access Journal |
| issn | 0250-5150 |
| language | English |
| last_indexed | 2024-04-10T14:27:48Z |
| publishDate | 2016-03-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
| spelling | doaj.art-ccccae16661b485dbfebf7e4bf8fe4162023-02-15T16:09:00ZengCukurova UniversityÇukurova Üniversitesi Tıp Fakültesi Dergisi0250-51502016-03-0141117818210.17826/cutf.157495200841Colistin administration for extensive drug-resistant Pseudomonas aeruginosa pneumonia in intensive care unit: case reportCetin Kilinc0Kemal Turker Ulutas1Beril Akcimen2Levent Celik3Nizami Duran4Tibbi Biyokimya, Antakya Devlet Hastanesi, Hatay D and acirc;hiliye bolumu, Kadirli Devlet Hastanesi, Osmaniye, Turkiye Radyoloji, Kadirli Devlet Hastanesi, Osmaniye, Turkiye Tibbi Mikrobiyoloji, Kadirli Devlet Hastanesi, Osmaniye, Turkiye Anestezi, Antakya Devlet Hastanesi, Hatay, TurkiyePseudomonas aeruginosa strains may develop the resistance to antibiotics via different mechanisms such as, alteration of protein binders of penicillin, porin mutations, DNA-gyrase mutation and active expulsion pumps. Especially, multi-drug resistant P.aeruginosa strains, are known to be most important cause of mortality in the intensive care units. Special antibiotic therapy is required, because of having the multiple antibiotic resistances. The case reports a 67-year-old male patient who had a history of 6 years paraplegia. He admitted to the emergency department with impaired general condition, including a week ongoing nausea,chest pain, cough, phlegm, wheezing and fatigue. Widespread crepitant rales were detected up to the middle and lower zones of both lungs. Besides, there was CRP elevation, hyperuricemia, a consolidated infiltration compatible with increased opacity at lower zone of right lung and reticulonodular style increased opacity at upper zone of right lung on chest .On disk diffusion, there was resistance to all antibiotics except colistin. Although colistin treatment was initiated, the patient was lost due to cardiac arrest at the 3rd day of treatment. This case is reported to be observed for the first time of P. aeruginosa infection that was extensively drug-resistant to antibiotics except colistin in our hospital, and to highlight importance of true treatment arrangements according to antibiotic susceptibility. [Cukurova Med J 2016; 41(1.000): 178-182]http://www.scopemed.org/fulltextpdf.php?mno=200841Pseudomonas aeruginosa colistin drug resistance intensive care |
| spellingShingle | Cetin Kilinc Kemal Turker Ulutas Beril Akcimen Levent Celik Nizami Duran Colistin administration for extensive drug-resistant Pseudomonas aeruginosa pneumonia in intensive care unit: case report Çukurova Üniversitesi Tıp Fakültesi Dergisi Pseudomonas aeruginosa colistin drug resistance intensive care |
| title | Colistin administration for extensive drug-resistant Pseudomonas aeruginosa pneumonia in intensive care unit: case report |
| title_full | Colistin administration for extensive drug-resistant Pseudomonas aeruginosa pneumonia in intensive care unit: case report |
| title_fullStr | Colistin administration for extensive drug-resistant Pseudomonas aeruginosa pneumonia in intensive care unit: case report |
| title_full_unstemmed | Colistin administration for extensive drug-resistant Pseudomonas aeruginosa pneumonia in intensive care unit: case report |
| title_short | Colistin administration for extensive drug-resistant Pseudomonas aeruginosa pneumonia in intensive care unit: case report |
| title_sort | colistin administration for extensive drug resistant pseudomonas aeruginosa pneumonia in intensive care unit case report |
| topic | Pseudomonas aeruginosa colistin drug resistance intensive care |
| url | http://www.scopemed.org/fulltextpdf.php?mno=200841 |
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