Determination of the Effects of Digoxin on the Right Ventricular Function in Patients Undergoing Pneumonectomy
Introduction: Pneumonectomy is the standard treatment of lung cancer, even though patients should undergo several evaluations before surgery; deterioration of cardiopulmonary function after pulmonary resection is inevitable. We have evaluated the effects of digoxin on the improvement of right ventri...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2014-02-01
|
| Series: | Journal of Cardio-Thoracic Medicine |
| Subjects: | |
| Online Access: | http://jctm.mums.ac.ir/pdf_2193_f657fd312bc715ad384e56239ad5e412.html |
| _version_ | 1818276520548892672 |
|---|---|
| author | Alireza Sharifian Attar Reza Jalaeian Taghaddomi Mohsen Moohebati Reza Bagheri Elahe Hosseinian |
| author_facet | Alireza Sharifian Attar Reza Jalaeian Taghaddomi Mohsen Moohebati Reza Bagheri Elahe Hosseinian |
| author_sort | Alireza Sharifian Attar |
| collection | DOAJ |
| description | Introduction: Pneumonectomy is the standard treatment of lung cancer, even though patients should undergo several evaluations before surgery; deterioration of cardiopulmonary function after pulmonary resection is inevitable. We have evaluated the effects of digoxin on the improvement of right ventricular function and prevention of probable complications after lung resection surgery. Materials and Methods: All patients who were candidate for pneumonectomy or extensive lobectomy in Ghaem hospital from 2010 to 2012 were enrolled into this study and were divided into two groups randomly. The first group (group D) received digoxin during surgery and in the second group (group C) normal saline was administered as placebo. Echocardiographic evaluation of the patients was accomplished the day before and the day after surgery. Results: Among 20 patients in each group, male to female ratio was almost 2:1 and mean age was 63.8 (ranged 46-83 years). The most common cause of pneumonectomy was lung cancer. Comparison of the preoperative demographic variables, blood biochemistry, pulmonary function tests, echocardiographic and blood gas indexes showed no statistically significant differences between two groups. ,But postoperative evaluations showed a significant improvement in left ventricular ejection fraction in group D. Right ventricular systolic and diastolic diameters and pulmonary artery pressure were decreased significantly as well. Conclusion: According to our results, we suggest a single dose of digoxin during lung resection surgery to improve cardiac performance after pneumonectomy. |
| first_indexed | 2024-12-12T22:46:57Z |
| format | Article |
| id | doaj.art-ccccfb3f44d042f487e69f5ef7cd04a2 |
| institution | Directory Open Access Journal |
| issn | 2345-2447 2322-5750 |
| language | English |
| last_indexed | 2024-12-12T22:46:57Z |
| publishDate | 2014-02-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardio-Thoracic Medicine |
| spelling | doaj.art-ccccfb3f44d042f487e69f5ef7cd04a22022-12-22T00:09:10ZengMashhad University of Medical SciencesJournal of Cardio-Thoracic Medicine2345-24472322-57502014-02-01211231262193Determination of the Effects of Digoxin on the Right Ventricular Function in Patients Undergoing PneumonectomyAlireza Sharifian Attar0Reza Jalaeian Taghaddomi1Mohsen Moohebati2Reza Bagheri3Elahe Hosseinian4Anesthesiologist, Cardio- Thoracic Surgery & Transplant Research Center, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranAnesthesiologist,Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranCardiologist, Department of Cardiology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranThoracic Surgery,Cardio- Thoracic Surgery & Transplant Research Center, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranResident of Anesthesiology, Department of Anesthesia, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IraIntroduction: Pneumonectomy is the standard treatment of lung cancer, even though patients should undergo several evaluations before surgery; deterioration of cardiopulmonary function after pulmonary resection is inevitable. We have evaluated the effects of digoxin on the improvement of right ventricular function and prevention of probable complications after lung resection surgery. Materials and Methods: All patients who were candidate for pneumonectomy or extensive lobectomy in Ghaem hospital from 2010 to 2012 were enrolled into this study and were divided into two groups randomly. The first group (group D) received digoxin during surgery and in the second group (group C) normal saline was administered as placebo. Echocardiographic evaluation of the patients was accomplished the day before and the day after surgery. Results: Among 20 patients in each group, male to female ratio was almost 2:1 and mean age was 63.8 (ranged 46-83 years). The most common cause of pneumonectomy was lung cancer. Comparison of the preoperative demographic variables, blood biochemistry, pulmonary function tests, echocardiographic and blood gas indexes showed no statistically significant differences between two groups. ,But postoperative evaluations showed a significant improvement in left ventricular ejection fraction in group D. Right ventricular systolic and diastolic diameters and pulmonary artery pressure were decreased significantly as well. Conclusion: According to our results, we suggest a single dose of digoxin during lung resection surgery to improve cardiac performance after pneumonectomy.http://jctm.mums.ac.ir/pdf_2193_f657fd312bc715ad384e56239ad5e412.htmlCardiopulmonary FunctionDigoxinPneumonectomy |
| spellingShingle | Alireza Sharifian Attar Reza Jalaeian Taghaddomi Mohsen Moohebati Reza Bagheri Elahe Hosseinian Determination of the Effects of Digoxin on the Right Ventricular Function in Patients Undergoing Pneumonectomy Journal of Cardio-Thoracic Medicine Cardiopulmonary Function Digoxin Pneumonectomy |
| title | Determination of the Effects of Digoxin on the Right Ventricular Function in Patients Undergoing Pneumonectomy |
| title_full | Determination of the Effects of Digoxin on the Right Ventricular Function in Patients Undergoing Pneumonectomy |
| title_fullStr | Determination of the Effects of Digoxin on the Right Ventricular Function in Patients Undergoing Pneumonectomy |
| title_full_unstemmed | Determination of the Effects of Digoxin on the Right Ventricular Function in Patients Undergoing Pneumonectomy |
| title_short | Determination of the Effects of Digoxin on the Right Ventricular Function in Patients Undergoing Pneumonectomy |
| title_sort | determination of the effects of digoxin on the right ventricular function in patients undergoing pneumonectomy |
| topic | Cardiopulmonary Function Digoxin Pneumonectomy |
| url | http://jctm.mums.ac.ir/pdf_2193_f657fd312bc715ad384e56239ad5e412.html |
| work_keys_str_mv | AT alirezasharifianattar determinationoftheeffectsofdigoxinontherightventricularfunctioninpatientsundergoingpneumonectomy AT rezajalaeiantaghaddomi determinationoftheeffectsofdigoxinontherightventricularfunctioninpatientsundergoingpneumonectomy AT mohsenmoohebati determinationoftheeffectsofdigoxinontherightventricularfunctioninpatientsundergoingpneumonectomy AT rezabagheri determinationoftheeffectsofdigoxinontherightventricularfunctioninpatientsundergoingpneumonectomy AT elahehosseinian determinationoftheeffectsofdigoxinontherightventricularfunctioninpatientsundergoingpneumonectomy |