A mechanistic updated overview on lycopene as potential anticancer agent
The potent relation between lycopene intake and reduced incidence of a variety of cancers has an increasing interest. This comprehensive review aims to highlight the in vivo and in vitro research evaluating the anticancer mechanisms of lycopene by underlining the experiment conditions. In addition t...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-05-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223002160 |
| _version_ | 1797857778987958272 |
|---|---|
| author | Gulay Ozkan Deniz Günal-Köroğlu Ayse Karadag Esra Capanoglu Susana M. Cardoso Basem Al-Omari Daniela Calina Javad Sharifi-Rad William C. Cho |
| author_facet | Gulay Ozkan Deniz Günal-Köroğlu Ayse Karadag Esra Capanoglu Susana M. Cardoso Basem Al-Omari Daniela Calina Javad Sharifi-Rad William C. Cho |
| author_sort | Gulay Ozkan |
| collection | DOAJ |
| description | The potent relation between lycopene intake and reduced incidence of a variety of cancers has an increasing interest. This comprehensive review aims to highlight the in vivo and in vitro research evaluating the anticancer mechanisms of lycopene by underlining the experiment conditions. In addition to these, the general characterization of lycopene has been explained.A collection of relevant scientific pharmacological articles from the following databases PubMed/MedLine, Web of Science, Scopus, TRIP database, and Google Scholar on the mechanisms of anticancer molecular action and cellular effects of lycopene in various types of tumors was performed. The anticancer potential of lycopene has been described by various in vitro cells, animal studies, and some clinical trials. It has been revealed that the anticancer potential of lycopene is mainly due to its powerful singlet-oxygen quencher characteristics, simulation of detoxifying/antioxidant enzymes production, initiation of apoptosis, inhibition of cell proliferation and cell cycle progression as well as modulations of gap junctional communication, the growth factors, and signal transduction pathways. It has been highlighted that the anticancer properties of lycopene are primarily linked to factors including; dose, presence of drug delivery systems, type of cancer, tumor size, and treatment time. |
| first_indexed | 2024-04-09T21:02:17Z |
| format | Article |
| id | doaj.art-cccf5057ee8141c0b01ccdd630abcd37 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-09T21:02:17Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-cccf5057ee8141c0b01ccdd630abcd372023-03-29T09:21:24ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-05-01161114428A mechanistic updated overview on lycopene as potential anticancer agentGulay Ozkan0Deniz Günal-Köroğlu1Ayse Karadag2Esra Capanoglu3Susana M. Cardoso4Basem Al-Omari5Daniela Calina6Javad Sharifi-Rad7William C. Cho8Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, TurkeyDepartment of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, TurkeyFaculty of Chemical and Metallurgical Engineering, Department of Food Engineering, Yildiz Technical University, Davutpasa Campus, Istanbul, TurkeyDepartment of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey; Corresponding authors.LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Epidemiology and Population Health, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates; Corresponding authors.Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania; Corresponding authors.Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador; Corresponding authors.Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong; Corresponding authors.The potent relation between lycopene intake and reduced incidence of a variety of cancers has an increasing interest. This comprehensive review aims to highlight the in vivo and in vitro research evaluating the anticancer mechanisms of lycopene by underlining the experiment conditions. In addition to these, the general characterization of lycopene has been explained.A collection of relevant scientific pharmacological articles from the following databases PubMed/MedLine, Web of Science, Scopus, TRIP database, and Google Scholar on the mechanisms of anticancer molecular action and cellular effects of lycopene in various types of tumors was performed. The anticancer potential of lycopene has been described by various in vitro cells, animal studies, and some clinical trials. It has been revealed that the anticancer potential of lycopene is mainly due to its powerful singlet-oxygen quencher characteristics, simulation of detoxifying/antioxidant enzymes production, initiation of apoptosis, inhibition of cell proliferation and cell cycle progression as well as modulations of gap junctional communication, the growth factors, and signal transduction pathways. It has been highlighted that the anticancer properties of lycopene are primarily linked to factors including; dose, presence of drug delivery systems, type of cancer, tumor size, and treatment time.http://www.sciencedirect.com/science/article/pii/S0753332223002160LycopeneAnticancer mechanismsApoptosisProliferationMetastasisClinical studies |
| spellingShingle | Gulay Ozkan Deniz Günal-Köroğlu Ayse Karadag Esra Capanoglu Susana M. Cardoso Basem Al-Omari Daniela Calina Javad Sharifi-Rad William C. Cho A mechanistic updated overview on lycopene as potential anticancer agent Biomedicine & Pharmacotherapy Lycopene Anticancer mechanisms Apoptosis Proliferation Metastasis Clinical studies |
| title | A mechanistic updated overview on lycopene as potential anticancer agent |
| title_full | A mechanistic updated overview on lycopene as potential anticancer agent |
| title_fullStr | A mechanistic updated overview on lycopene as potential anticancer agent |
| title_full_unstemmed | A mechanistic updated overview on lycopene as potential anticancer agent |
| title_short | A mechanistic updated overview on lycopene as potential anticancer agent |
| title_sort | mechanistic updated overview on lycopene as potential anticancer agent |
| topic | Lycopene Anticancer mechanisms Apoptosis Proliferation Metastasis Clinical studies |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223002160 |
| work_keys_str_mv | AT gulayozkan amechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT denizgunalkoroglu amechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT aysekaradag amechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT esracapanoglu amechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT susanamcardoso amechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT basemalomari amechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT danielacalina amechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT javadsharifirad amechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT williamccho amechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT gulayozkan mechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT denizgunalkoroglu mechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT aysekaradag mechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT esracapanoglu mechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT susanamcardoso mechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT basemalomari mechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT danielacalina mechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT javadsharifirad mechanisticupdatedoverviewonlycopeneaspotentialanticanceragent AT williamccho mechanisticupdatedoverviewonlycopeneaspotentialanticanceragent |