Cyclin D1 and p21 gene variants and oral squamous cell carcinoma risk and prognosis
Cyclin-dependent kinase inhibitor p21 (encoded by the CDKN1A gene) and cyclin D1 (encoded by the CCND1 gene) are important regulators of cell cycle progression and could have important effects in the complex process of neoplastic transformation. The current study aimed to investigate variants in CDK...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2021-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2021/0354-46642100037J.pdf |
| _version_ | 1818333306915127296 |
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| author | Jović Saša Zeljić Katarina Ivković Nemanja Štefik Debora Kozomara Ružica Stošić Srboljub Šupić Gordana |
| author_facet | Jović Saša Zeljić Katarina Ivković Nemanja Štefik Debora Kozomara Ružica Stošić Srboljub Šupić Gordana |
| author_sort | Jović Saša |
| collection | DOAJ |
| description | Cyclin-dependent kinase inhibitor p21 (encoded by the CDKN1A gene) and cyclin D1 (encoded by the CCND1 gene) are important regulators of cell cycle progression and could have important effects in the complex process of neoplastic transformation. The current study aimed to investigate variants in CDKN1A (rs1801270, rs1059234) and CCND1 (rs9344) genes as potential risk and prognostic factors in oral squamous cell carcinoma (OSCC) patients. The study included 104 OSCC patients and 107 healthy individuals without a history of cancer. Genotypes were assessed by real-time PCR and TaqMan SNP genotyping. Significant differences in genotype distribution between OSCC cases and the control group were observed for the CCND1 rs9344 variant (p=0.017). According to the odds ratio (OR), adjusted for age and sex, the rs9344 heterozygous GA and homozygous mutated AA genotypes were associated with an increased OSCC susceptibility (OR=2.295, p=0.007; OR=2.029, p=0.037, respectively). Variants rs1801270 and rs105923 in CDKN1A were not associated with OSCC risk. There were no differences in overall survival among OSCC patients stratified by genotypes of the analyzed variants in CDKN1A and CCND1. Variant rs9344 in the CCND1 gene might be considered as a potential molecular risk factor for OSCC susceptibility but not for disease prognosis. |
| first_indexed | 2024-12-13T13:49:33Z |
| format | Article |
| id | doaj.art-ccd06d7cd84344eda5b47c0aa1aebb94 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-13T13:49:33Z |
| publishDate | 2021-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-ccd06d7cd84344eda5b47c0aa1aebb942022-12-21T23:43:16ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392021-01-0173443744510.2298/ABS210813037J0354-46642100037JCyclin D1 and p21 gene variants and oral squamous cell carcinoma risk and prognosisJović Saša0Zeljić Katarina1https://orcid.org/0000-0002-6545-8616Ivković Nemanja2https://orcid.org/0000-0001-8982-8848Štefik Debora3https://orcid.org/0000-0001-6610-4812Kozomara Ružica4Stošić Srboljub5Šupić Gordana6https://orcid.org/0000-0003-0350-4733Clinic for Maxillofacial Surgery, Military Medical Academy, Belgrade, Serbia + Medical Faculty of Military Medical Academy, University of Defense, Belgrade, SerbiaFaculty of Biology, University of Belgrade, Belgrade, SerbiaInstitute of Medical Research, Military Medical Academy, Belgrade, SerbiaInstitute of Medical Research, Military Medical Academy, Belgrade, SerbiaClinic for Maxillofacial Surgery, Military Medical Academy, Belgrade, Serbia + Medical Faculty of Military Medical Academy, University of Defense, Belgrade, SerbiaClinic for Maxillofacial Surgery, Military Medical Academy, Belgrade, Serbia + Medical Faculty of Military Medical Academy, University of Defense, Belgrade, SerbiaMedical Faculty of Military Medical Academy, University of Defense, Belgrade, Serbia + Institute of Medical Research, Military Medical Academy, Belgrade, SerbiaCyclin-dependent kinase inhibitor p21 (encoded by the CDKN1A gene) and cyclin D1 (encoded by the CCND1 gene) are important regulators of cell cycle progression and could have important effects in the complex process of neoplastic transformation. The current study aimed to investigate variants in CDKN1A (rs1801270, rs1059234) and CCND1 (rs9344) genes as potential risk and prognostic factors in oral squamous cell carcinoma (OSCC) patients. The study included 104 OSCC patients and 107 healthy individuals without a history of cancer. Genotypes were assessed by real-time PCR and TaqMan SNP genotyping. Significant differences in genotype distribution between OSCC cases and the control group were observed for the CCND1 rs9344 variant (p=0.017). According to the odds ratio (OR), adjusted for age and sex, the rs9344 heterozygous GA and homozygous mutated AA genotypes were associated with an increased OSCC susceptibility (OR=2.295, p=0.007; OR=2.029, p=0.037, respectively). Variants rs1801270 and rs105923 in CDKN1A were not associated with OSCC risk. There were no differences in overall survival among OSCC patients stratified by genotypes of the analyzed variants in CDKN1A and CCND1. Variant rs9344 in the CCND1 gene might be considered as a potential molecular risk factor for OSCC susceptibility but not for disease prognosis.http://www.doiserbia.nb.rs/img/doi/0354-4664/2021/0354-46642100037J.pdfp21cyclin d1gene polymorphismoral squamous cell carcinoma |
| spellingShingle | Jović Saša Zeljić Katarina Ivković Nemanja Štefik Debora Kozomara Ružica Stošić Srboljub Šupić Gordana Cyclin D1 and p21 gene variants and oral squamous cell carcinoma risk and prognosis Archives of Biological Sciences p21 cyclin d1 gene polymorphism oral squamous cell carcinoma |
| title | Cyclin D1 and p21 gene variants and oral squamous cell carcinoma risk and prognosis |
| title_full | Cyclin D1 and p21 gene variants and oral squamous cell carcinoma risk and prognosis |
| title_fullStr | Cyclin D1 and p21 gene variants and oral squamous cell carcinoma risk and prognosis |
| title_full_unstemmed | Cyclin D1 and p21 gene variants and oral squamous cell carcinoma risk and prognosis |
| title_short | Cyclin D1 and p21 gene variants and oral squamous cell carcinoma risk and prognosis |
| title_sort | cyclin d1 and p21 gene variants and oral squamous cell carcinoma risk and prognosis |
| topic | p21 cyclin d1 gene polymorphism oral squamous cell carcinoma |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2021/0354-46642100037J.pdf |
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