Estimation of Pro-Inflammatory Markers In Night Shift Healthcare Workers And Identify Risk Factors Associated With It
Shift labor, with hours outside of the regular diurnal work cycle, is used to facilitate round-the-clock emergency healthcare services. This impacts the circadian rhythm, which can potentially activate the pro-inflammatory responses of the immune system. This study aimed to find out the levels of p...
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| Format: | Article |
| Language: | English |
| Published: |
ACHSM
2024-03-01
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| Series: | Asia Pacific Journal of Health Management |
| Subjects: | |
| Online Access: | https://journal.achsm.org.au/index.php/achsm/article/view/2599 |
| _version_ | 1797265762970238976 |
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| author | Jyotirmayee Bahinipati Baibhav Agrawal Rajlaxmi Sarangi RG ASUTOSH MOHAPATRA Mona Pathak Srikrushna Mahapatra Soumya Ranjan MOHAPATRA |
| author_facet | Jyotirmayee Bahinipati Baibhav Agrawal Rajlaxmi Sarangi RG ASUTOSH MOHAPATRA Mona Pathak Srikrushna Mahapatra Soumya Ranjan MOHAPATRA |
| author_sort | Jyotirmayee Bahinipati |
| collection | DOAJ |
| description |
Shift labor, with hours outside of the regular diurnal work cycle, is used to facilitate round-the-clock emergency healthcare services. This impacts the circadian rhythm, which can potentially activate the pro-inflammatory responses of the immune system. This study aimed to find out the levels of pro-inflammatory markers in night shift healthcare workers and find risk factors associated with their increase.
303 participants (doctors, nurses, technicians, health care aids) were recruited with 169 participants nightshift and 134 dayshift workers. Pro-inflammatory markers Highly Sensitive C-Reactive Protein (hsCRP) and Total Leukocyte Count (TLC)] were estimated. Factors were compared by t test, Wilcoxon Rank Sum test and Chi square test. Risk factors for hsCRP elevation were identified by logistic regression analysis.
Pro-inflammatory markers like hsCRP and TLC were significantly increased in night shift health workers in comparison to the day shift workers (hsCRP 0.30± 0.33 mg/dl vs 0.10± 0.09 mg/dl, TLC 8181.06± 1181.53 /cu mm vs 7473.80± 1018.81 /cu mm) respectively. Multivariate logistic regression analysis showed night shift work (OR 48.20 95% CI (4.99-465.61), age (OR 1.13 95% CI (1.01-1.26)) and BMI (OR 1.18 95% CI (1.06-1.32)) as independent predictors of elevated hsCRP after adjusting for other risk factors. Hence, night-shift work is an independent risk factor for a rise in pro-inflammatory markers. These findings might aid health care workers and policymakers strategize methods to tackle the challenges through providing support programs, counselling sessions to avoid ailments and deliver health services in a better way.
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| first_indexed | 2024-03-07T14:07:17Z |
| format | Article |
| id | doaj.art-ccd23d1f98334253bc5d4d0188969810 |
| institution | Directory Open Access Journal |
| issn | 1833-3818 2204-3136 |
| language | English |
| last_indexed | 2024-04-25T00:49:57Z |
| publishDate | 2024-03-01 |
| publisher | ACHSM |
| record_format | Article |
| series | Asia Pacific Journal of Health Management |
| spelling | doaj.art-ccd23d1f98334253bc5d4d01889698102024-03-11T18:56:46ZengACHSMAsia Pacific Journal of Health Management1833-38182204-31362024-03-0110.24083/apjhm.v19i1.2599Estimation of Pro-Inflammatory Markers In Night Shift Healthcare Workers And Identify Risk Factors Associated With ItJyotirmayee Bahinipati0Baibhav AgrawalRajlaxmi SarangiRG ASUTOSH MOHAPATRAMona PathakSrikrushna MahapatraSoumya Ranjan MOHAPATRAa:1:{s:5:"en_US";s:28:"Professor, MD (Biochemistry)";} Shift labor, with hours outside of the regular diurnal work cycle, is used to facilitate round-the-clock emergency healthcare services. This impacts the circadian rhythm, which can potentially activate the pro-inflammatory responses of the immune system. This study aimed to find out the levels of pro-inflammatory markers in night shift healthcare workers and find risk factors associated with their increase. 303 participants (doctors, nurses, technicians, health care aids) were recruited with 169 participants nightshift and 134 dayshift workers. Pro-inflammatory markers Highly Sensitive C-Reactive Protein (hsCRP) and Total Leukocyte Count (TLC)] were estimated. Factors were compared by t test, Wilcoxon Rank Sum test and Chi square test. Risk factors for hsCRP elevation were identified by logistic regression analysis. Pro-inflammatory markers like hsCRP and TLC were significantly increased in night shift health workers in comparison to the day shift workers (hsCRP 0.30± 0.33 mg/dl vs 0.10± 0.09 mg/dl, TLC 8181.06± 1181.53 /cu mm vs 7473.80± 1018.81 /cu mm) respectively. Multivariate logistic regression analysis showed night shift work (OR 48.20 95% CI (4.99-465.61), age (OR 1.13 95% CI (1.01-1.26)) and BMI (OR 1.18 95% CI (1.06-1.32)) as independent predictors of elevated hsCRP after adjusting for other risk factors. Hence, night-shift work is an independent risk factor for a rise in pro-inflammatory markers. These findings might aid health care workers and policymakers strategize methods to tackle the challenges through providing support programs, counselling sessions to avoid ailments and deliver health services in a better way. https://journal.achsm.org.au/index.php/achsm/article/view/2599inflammatory markershsCRPTLCBMIcardio-metabolic diseases.shift work |
| spellingShingle | Jyotirmayee Bahinipati Baibhav Agrawal Rajlaxmi Sarangi RG ASUTOSH MOHAPATRA Mona Pathak Srikrushna Mahapatra Soumya Ranjan MOHAPATRA Estimation of Pro-Inflammatory Markers In Night Shift Healthcare Workers And Identify Risk Factors Associated With It Asia Pacific Journal of Health Management inflammatory markers hsCRP TLC BMI cardio-metabolic diseases. shift work |
| title | Estimation of Pro-Inflammatory Markers In Night Shift Healthcare Workers And Identify Risk Factors Associated With It |
| title_full | Estimation of Pro-Inflammatory Markers In Night Shift Healthcare Workers And Identify Risk Factors Associated With It |
| title_fullStr | Estimation of Pro-Inflammatory Markers In Night Shift Healthcare Workers And Identify Risk Factors Associated With It |
| title_full_unstemmed | Estimation of Pro-Inflammatory Markers In Night Shift Healthcare Workers And Identify Risk Factors Associated With It |
| title_short | Estimation of Pro-Inflammatory Markers In Night Shift Healthcare Workers And Identify Risk Factors Associated With It |
| title_sort | estimation of pro inflammatory markers in night shift healthcare workers and identify risk factors associated with it |
| topic | inflammatory markers hsCRP TLC BMI cardio-metabolic diseases. shift work |
| url | https://journal.achsm.org.au/index.php/achsm/article/view/2599 |
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