Doxycycline and hydroxypropyl-β-cyclodextrin complex in poloxamer thermal sensitive hydrogel for ophthalmic delivery

Doxycycline and hydroxypropyl-β-cyclodextrin complex in poloxamer thermal sensitive hydrogel for ophthalmic delivery

The present study aimed to prepare a chemically and physically stable formulation of doxycycline (Doxy) in an in situ thermally sensitive hydrogel for ophthalmic delivery. An inclusion complex of Doxy and hydroxypropyl-β-cyclodextrin (HP-β-CD) was first developed to increase the stability of Doxy in...

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Bibliographic Details
Main Authors:	Zi-xin He, Zhou-hua Wang, Hao-hao Zhang, Xin Pan, Wen-ru Su, Dan Liang, Chuan-bin Wu
Format:	Article
Language:	English
Published:	Elsevier 2011-12-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Doxycycline HP-β-CD Corneal neovascularization Thermally sensitive Hydrogel
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383511000840

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