The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain

The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain

<p>Abstract</p> <p>Background</p> <p>Oxidized linoleic acid metabolites (OLAMs) are a class of endogenous agonists to the transient receptor potential V1 (TRPV1) receptor. Although TRPV1 mediates inflammatory heat hyperalgesia, it is not known if the OLAMs contribute to...

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Bibliographic Details
Main Authors: Ruparel Shivani, Green Dustin, Chen Paul, Hargreaves Kenneth M
Format: Article
Language:English
Published: SAGE Publishing 2012-09-01
Series:Molecular Pain
Subjects:
Cytochrome P450
TRPV1
OLAMs
Inflammation
Online Access:http://www.molecularpain.com/content/8/1/73

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