IL-7 producing immunotherapy improves ex vivo T cell functions of immunosenescent patients, especially post hip fracture

IL-7 producing immunotherapy improves ex vivo T cell functions of immunosenescent patients, especially post hip fracture

Following acute stress such as trauma or sepsis, most of critically ill elderly patients become immunosuppressed and susceptible to secondary infections and enhanced mortality. We have developed a virus-based immunotherapy encoding human interleukin-7 (hIL-7) aiming at restoring both innate an adapt...

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Bibliographic Details
Main Authors: Chrystel Marton, Alix Minaud, Charles-Antoine Coupet, Manon Chauvin, Jamila Dhiab, Hélène Vallet, Jacques Boddaert, Nadine Kehrer, Bérangère Bastien, Geneviève Inchauspe, Luc Barraud, Delphine Sauce
Format: Article
Language:English
Published: Taylor & Francis Group 2023-08-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
immunosenescence
hip fracture
immunotherapy
virotherapy
interleukin-7
t-cell functions
trauma
immunosuppression
cytokine
Online Access:http://dx.doi.org/10.1080/21645515.2023.2232247

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