Three-month follow-up after severe COVID-19 infection: are chest CT results associated with respiratory outcomes and respiratory recovery in COVID-19 patients?
Abstract Background CT Severity Score (CT-SS) can be used to assess the extent of severe coronavirus disease 19 (COVID-19) pneumonia. Follow-up CT-SS in patients surviving COVID-19-associated hyperinflammation and its correlation with respiratory parameters remains unknown. This study aims to assess...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-023-02370-2 |
| _version_ | 1797865700806623232 |
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| author | Marlou THF Janssen Mark GH Thijssen Jasenko Krdzalic Michiel HM Gronenschild Sofia Ramiro César Magro-Checa Robert BM Landewé Rémy LM Mostard |
| author_facet | Marlou THF Janssen Mark GH Thijssen Jasenko Krdzalic Michiel HM Gronenschild Sofia Ramiro César Magro-Checa Robert BM Landewé Rémy LM Mostard |
| author_sort | Marlou THF Janssen |
| collection | DOAJ |
| description | Abstract Background CT Severity Score (CT-SS) can be used to assess the extent of severe coronavirus disease 19 (COVID-19) pneumonia. Follow-up CT-SS in patients surviving COVID-19-associated hyperinflammation and its correlation with respiratory parameters remains unknown. This study aims to assess the association between CT-SS and respiratory outcomes, both in hospital and at three months after hospitalization. Methods Patients from the COVID-19 High-intensity Immunosuppression in Cytokine storm Syndrome (CHIC) study surviving hospitalization due to COVID-19 associated hyperinflammation were invited for follow-up assessment at three months after hospitalization. Results of CT-SS three months after hospitalization were compared with CT-SS at hospital admission. CT-SS at admission and at 3-months were correlated with respiratory status during hospitalization and with patient reported outcomes as well as pulmonary- and exercise function tests at 3-months after hospitalization. Results A total of 113 patients were included. Mean CT-SS decreased by 40.4% (SD 27.6) in three months (P < 0.001). CT-SS during hospitalization was higher in patients requiring more oxygen (P < 0.001). CT-SS at 3-months was higher in patients with more dyspnoea (CT-SS 8.31 (3.98) in patients with modified Medical Council Dyspnoea scale (mMRC) 0–2 vs. 11.03 (4.47) in those with mMRC 3–4). CT-SS at 3-months was also higher in patients with a more impaired pulmonary function (7.4 (3.6) in patients with diffusing capacity for carbon monoxide (DLCO) > 80%pred vs. 14.3 (3.2) in those with DLCO < 40%pred, P = 0.002). Conclusion Patients surviving hospitalization for COVID-19-associated hyperinflammation with higher CT-SS have worse respiratory outcome, both in-hospital and at 3-months after hospitalization. Strict monitoring of patients with high CT-SS is therefore warranted. |
| first_indexed | 2024-04-09T23:12:23Z |
| format | Article |
| id | doaj.art-ccdb13dd622a4648adb608a9fdab9f6b |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-09T23:12:23Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-ccdb13dd622a4648adb608a9fdab9f6b2023-03-22T10:19:16ZengBMCBMC Pulmonary Medicine1471-24662023-03-0123111010.1186/s12890-023-02370-2Three-month follow-up after severe COVID-19 infection: are chest CT results associated with respiratory outcomes and respiratory recovery in COVID-19 patients?Marlou THF Janssen0Mark GH Thijssen1Jasenko Krdzalic2Michiel HM Gronenschild3Sofia Ramiro4César Magro-Checa5Robert BM Landewé6Rémy LM Mostard7Department of Pulmonology, Zuyderland Medical CentreDepartment of Pulmonology, Zuyderland Medical CentreDepartment of Radiology, Zuyderland Medical CentreDepartment of Pulmonology, Zuyderland Medical CentreDepartment of Rheumatology, Zuyderland Medical CentreDepartment of Rheumatology, Zuyderland Medical CentreDepartment of Rheumatology, Zuyderland Medical CentreDepartment of Pulmonology, Zuyderland Medical CentreAbstract Background CT Severity Score (CT-SS) can be used to assess the extent of severe coronavirus disease 19 (COVID-19) pneumonia. Follow-up CT-SS in patients surviving COVID-19-associated hyperinflammation and its correlation with respiratory parameters remains unknown. This study aims to assess the association between CT-SS and respiratory outcomes, both in hospital and at three months after hospitalization. Methods Patients from the COVID-19 High-intensity Immunosuppression in Cytokine storm Syndrome (CHIC) study surviving hospitalization due to COVID-19 associated hyperinflammation were invited for follow-up assessment at three months after hospitalization. Results of CT-SS three months after hospitalization were compared with CT-SS at hospital admission. CT-SS at admission and at 3-months were correlated with respiratory status during hospitalization and with patient reported outcomes as well as pulmonary- and exercise function tests at 3-months after hospitalization. Results A total of 113 patients were included. Mean CT-SS decreased by 40.4% (SD 27.6) in three months (P < 0.001). CT-SS during hospitalization was higher in patients requiring more oxygen (P < 0.001). CT-SS at 3-months was higher in patients with more dyspnoea (CT-SS 8.31 (3.98) in patients with modified Medical Council Dyspnoea scale (mMRC) 0–2 vs. 11.03 (4.47) in those with mMRC 3–4). CT-SS at 3-months was also higher in patients with a more impaired pulmonary function (7.4 (3.6) in patients with diffusing capacity for carbon monoxide (DLCO) > 80%pred vs. 14.3 (3.2) in those with DLCO < 40%pred, P = 0.002). Conclusion Patients surviving hospitalization for COVID-19-associated hyperinflammation with higher CT-SS have worse respiratory outcome, both in-hospital and at 3-months after hospitalization. Strict monitoring of patients with high CT-SS is therefore warranted.https://doi.org/10.1186/s12890-023-02370-2COVID-19HyperinflammationCT severity score |
| spellingShingle | Marlou THF Janssen Mark GH Thijssen Jasenko Krdzalic Michiel HM Gronenschild Sofia Ramiro César Magro-Checa Robert BM Landewé Rémy LM Mostard Three-month follow-up after severe COVID-19 infection: are chest CT results associated with respiratory outcomes and respiratory recovery in COVID-19 patients? BMC Pulmonary Medicine COVID-19 Hyperinflammation CT severity score |
| title | Three-month follow-up after severe COVID-19 infection: are chest CT results associated with respiratory outcomes and respiratory recovery in COVID-19 patients? |
| title_full | Three-month follow-up after severe COVID-19 infection: are chest CT results associated with respiratory outcomes and respiratory recovery in COVID-19 patients? |
| title_fullStr | Three-month follow-up after severe COVID-19 infection: are chest CT results associated with respiratory outcomes and respiratory recovery in COVID-19 patients? |
| title_full_unstemmed | Three-month follow-up after severe COVID-19 infection: are chest CT results associated with respiratory outcomes and respiratory recovery in COVID-19 patients? |
| title_short | Three-month follow-up after severe COVID-19 infection: are chest CT results associated with respiratory outcomes and respiratory recovery in COVID-19 patients? |
| title_sort | three month follow up after severe covid 19 infection are chest ct results associated with respiratory outcomes and respiratory recovery in covid 19 patients |
| topic | COVID-19 Hyperinflammation CT severity score |
| url | https://doi.org/10.1186/s12890-023-02370-2 |
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