Family history of mood disorder weakens the association between personality traits and suicidality in depressed patients
Introduction Depression is associated with a high risk of suicidal thoughts (ST) and behaviour (SB). Suicidality and depression have partially shared genetic underpinnings and family history of mood disorders (FH) can reflect genetic impact on specific features of depression. Thus, in depressed pat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822021721/type/journal_article |
| _version_ | 1797617159768113152 |
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| author | A. Kibitov A. Nikolishin N. Neznanov G. Mazo A. Kibitov |
| author_facet | A. Kibitov A. Nikolishin N. Neznanov G. Mazo A. Kibitov |
| author_sort | A. Kibitov |
| collection | DOAJ |
| description |
Introduction
Depression is associated with a high risk of suicidal thoughts (ST) and behaviour (SB). Suicidality and depression have partially shared genetic underpinnings and family history of mood disorders (FH) can reflect genetic impact on specific features of depression. Thus, in depressed patients, FH may affect suicidality and its associations with other risk factors, such as personality traits.
Objectives
We conducted a cross-sectional study to test the impact of FH on the association between suicidality and personality traits in depressed patients.
Methods
200 depression in- and outpatients (64% (n=128) women, mean age (M(SD):36,21(15,09)) were enrolled. 28% (n=56) reported FH (“FH+” cohort), other patients comprised the “FH-” cohort. Columbia-Suicide Severity Rating Scale (C-SSRS) was used to assess ST and SB during the most suicidal period of life. Personality traits were assessed by Cloninger Temperament and Character Inventory (TCI-125). Information about FH and history of suicide attempts (SA) was obtained during the clinical interview.
Results
Personality traits and suicidality characteristics (ST, SB, SA) did not differ between FH+ and FH- patients. In FH+, no differences in TCI-125 scores between suicide attempters and non-attempters were found, while in FH-, attempters had higher scores of TCI-125 “Novelty seeking” (p=0.002) and “Self-transcendence” (p=0.031) subscales. Multiple correlations between ST, SB and TCI-125 subscales were found only in FH-, In FH+, only one correlation (between ST and TCI-125 “Persistence” subscale (r=-0.288, p=0.038) was found.
Conclusions
Our results showed a weakened association between personality traits and suicidality in depressed patients with FH of mood disorders, although more data on larger samples are needed.
Disclosure
The study was supported by RSF grant # 20-15-00132
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| first_indexed | 2024-03-11T07:51:53Z |
| format | Article |
| id | doaj.art-ccdcbb06c2e24851918e79a68fc01356 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:51:53Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-ccdcbb06c2e24851918e79a68fc013562023-11-17T05:06:42ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S839S83910.1192/j.eurpsy.2022.2172Family history of mood disorder weakens the association between personality traits and suicidality in depressed patientsA. Kibitov0A. Nikolishin1N. Neznanov2G. Mazo3A. Kibitov4Bekhterev National Medical Research Center for Psychiatry and Neurology, Translational Psychiatry Department, Saint-Petersburg , Russian FederationFederal State Budgetary Istitution Serbsky National Medical Research Centre for Psychiatry and Narcology of Ministry of Heath of the Russian Federation, Laboratory Of Molecular Genetics, Moscow, Russian FederationBekhterev National Medical Center for Psychiatry and Neurology, Geriatric Psychiatry, Saint-Petersburg , Russian FederationBekhterev National Medical Research Center for Psychiatry and Neurology, Translational Psychiatry Deartment, Saint-Petersburg , Russian FederationSerbsky National Medical Research Center on Psychiatry and Addictions, Molecular Genetics Laboratory, Moscow, Russian Federation Introduction Depression is associated with a high risk of suicidal thoughts (ST) and behaviour (SB). Suicidality and depression have partially shared genetic underpinnings and family history of mood disorders (FH) can reflect genetic impact on specific features of depression. Thus, in depressed patients, FH may affect suicidality and its associations with other risk factors, such as personality traits. Objectives We conducted a cross-sectional study to test the impact of FH on the association between suicidality and personality traits in depressed patients. Methods 200 depression in- and outpatients (64% (n=128) women, mean age (M(SD):36,21(15,09)) were enrolled. 28% (n=56) reported FH (“FH+” cohort), other patients comprised the “FH-” cohort. Columbia-Suicide Severity Rating Scale (C-SSRS) was used to assess ST and SB during the most suicidal period of life. Personality traits were assessed by Cloninger Temperament and Character Inventory (TCI-125). Information about FH and history of suicide attempts (SA) was obtained during the clinical interview. Results Personality traits and suicidality characteristics (ST, SB, SA) did not differ between FH+ and FH- patients. In FH+, no differences in TCI-125 scores between suicide attempters and non-attempters were found, while in FH-, attempters had higher scores of TCI-125 “Novelty seeking” (p=0.002) and “Self-transcendence” (p=0.031) subscales. Multiple correlations between ST, SB and TCI-125 subscales were found only in FH-, In FH+, only one correlation (between ST and TCI-125 “Persistence” subscale (r=-0.288, p=0.038) was found. Conclusions Our results showed a weakened association between personality traits and suicidality in depressed patients with FH of mood disorders, although more data on larger samples are needed. Disclosure The study was supported by RSF grant # 20-15-00132 https://www.cambridge.org/core/product/identifier/S0924933822021721/type/journal_articleSuicideDepressionFamily history |
| spellingShingle | A. Kibitov A. Nikolishin N. Neznanov G. Mazo A. Kibitov Family history of mood disorder weakens the association between personality traits and suicidality in depressed patients European Psychiatry Suicide Depression Family history |
| title | Family history of mood disorder weakens the association between personality traits and suicidality in depressed patients |
| title_full | Family history of mood disorder weakens the association between personality traits and suicidality in depressed patients |
| title_fullStr | Family history of mood disorder weakens the association between personality traits and suicidality in depressed patients |
| title_full_unstemmed | Family history of mood disorder weakens the association between personality traits and suicidality in depressed patients |
| title_short | Family history of mood disorder weakens the association between personality traits and suicidality in depressed patients |
| title_sort | family history of mood disorder weakens the association between personality traits and suicidality in depressed patients |
| topic | Suicide Depression Family history |
| url | https://www.cambridge.org/core/product/identifier/S0924933822021721/type/journal_article |
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