The Effect of Opium Dependency of Parent (s) on Offspring’s Spatial Learning & Memory in Adult Male Rats
Objective(s):As far as we know,there has been no report regarding the effects of opium addiction or dependency of both parents on the learning and memory process in offspring. The aim of this study was to examine the learning and memory changes of adult male offspring whose mothers, fathers and/or b...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2013-05-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | http://ijbms.mums.ac.ir/pdf_782_942f2e385927e7f727cb9a09bf889578.html |
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| author | Arezoo Saberi Moghadam Gholamreza Sepehri Vahid Sheibani Tahereh Haghpanah Kouros Divsalar Mousa-Al-Reza Hajzadeh Mohammadreza Afarineshkhaki |
| author_facet | Arezoo Saberi Moghadam Gholamreza Sepehri Vahid Sheibani Tahereh Haghpanah Kouros Divsalar Mousa-Al-Reza Hajzadeh Mohammadreza Afarineshkhaki |
| author_sort | Arezoo Saberi Moghadam |
| collection | DOAJ |
| description | Objective(s):As far as we know,there has been no report regarding the effects of opium addiction or dependency of both parents on the learning and memory process in offspring. The aim of this study was to examine the learning and memory changes of adult male offspring whose mothers, fathers and/or both parents had dependency to opium before and during pregnancy. Materials and Methods: All experiments were carried out on Wistar rats. Opium dependency was induced by daily injections of opium (10 mg/kg/SC, bid/10 d) before mating. The presence of a vaginal plug was designated as gestation day. Treatment with opium continued through breeding and gestation until parturition. Spatial memory was tested in male offspring of control, saline and prenatal opium treated groups by a training trial and the probe test in the Morris water maze. Swimming escape latency in the maze and the ability to find the platform in the training trial were recorded. The time spent in the trigger zone and number of times the rats crossed the platform during the probe phase and swimming speed were measured. Results:Thedata revealed increased escape latency and a greater distance traveled to find the hidden platform in the offspring’s whose mother, father and /or both parents were exposed to opium. Crossings to target quadrant at probe trials was significantly reduced in all of the prenatal opium exposed offsprings. The swimming speed showed a significant increase in father and parent’s opium exposed offspring. Conclusion:Prenatal opium exposure of either parent may cause deficits in spatial learning, but the precise mechanism(s) remain largely unknown. |
| first_indexed | 2024-04-12T23:37:32Z |
| format | Article |
| id | doaj.art-ccdd672f6b464035bc912baa8846c7bc |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-12T23:37:32Z |
| publishDate | 2013-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-ccdd672f6b464035bc912baa8846c7bc2022-12-22T03:12:05ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742013-05-01165694699782The Effect of Opium Dependency of Parent (s) on Offspring’s Spatial Learning & Memory in Adult Male RatsArezoo Saberi Moghadam0Gholamreza Sepehri1Vahid Sheibani2Tahereh Haghpanah3Kouros Divsalar4Mousa-Al-Reza Hajzadeh5Mohammadreza Afarineshkhaki6Kerman Neuroscience Research Center, Kerman University of Medical Sciences Kerman, IranKerman Neuroscience Research Center, Kerman University of Medical Sciences Kerman, IranKerman Neuroscience Research Center, Kerman University of Medical Sciences Kerman, IranDepartment of Anatomical and Reproductive Biology, Faculty of Medical sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranKerman Neuroscience Research Center, Kerman University of Medical Sciences Kerman, IranMashhad Cognitive Neuroscience Research Center and Department of Physiology, Faculty ofMedical sciences, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Physiology and Medical Student Research Committee, Faculty of Medical sciences, Shahid Beheshti University of Medical Sciences. Tehran, IranObjective(s):As far as we know,there has been no report regarding the effects of opium addiction or dependency of both parents on the learning and memory process in offspring. The aim of this study was to examine the learning and memory changes of adult male offspring whose mothers, fathers and/or both parents had dependency to opium before and during pregnancy. Materials and Methods: All experiments were carried out on Wistar rats. Opium dependency was induced by daily injections of opium (10 mg/kg/SC, bid/10 d) before mating. The presence of a vaginal plug was designated as gestation day. Treatment with opium continued through breeding and gestation until parturition. Spatial memory was tested in male offspring of control, saline and prenatal opium treated groups by a training trial and the probe test in the Morris water maze. Swimming escape latency in the maze and the ability to find the platform in the training trial were recorded. The time spent in the trigger zone and number of times the rats crossed the platform during the probe phase and swimming speed were measured. Results:Thedata revealed increased escape latency and a greater distance traveled to find the hidden platform in the offspring’s whose mother, father and /or both parents were exposed to opium. Crossings to target quadrant at probe trials was significantly reduced in all of the prenatal opium exposed offsprings. The swimming speed showed a significant increase in father and parent’s opium exposed offspring. Conclusion:Prenatal opium exposure of either parent may cause deficits in spatial learning, but the precise mechanism(s) remain largely unknown.http://ijbms.mums.ac.ir/pdf_782_942f2e385927e7f727cb9a09bf889578.htmlLearning Memory Opium Parent (s) dependency Rat |
| spellingShingle | Arezoo Saberi Moghadam Gholamreza Sepehri Vahid Sheibani Tahereh Haghpanah Kouros Divsalar Mousa-Al-Reza Hajzadeh Mohammadreza Afarineshkhaki The Effect of Opium Dependency of Parent (s) on Offspring’s Spatial Learning & Memory in Adult Male Rats Iranian Journal of Basic Medical Sciences Learning Memory Opium Parent (s) dependency Rat |
| title | The Effect of Opium Dependency of Parent (s) on Offspring’s Spatial Learning & Memory in Adult Male Rats |
| title_full | The Effect of Opium Dependency of Parent (s) on Offspring’s Spatial Learning & Memory in Adult Male Rats |
| title_fullStr | The Effect of Opium Dependency of Parent (s) on Offspring’s Spatial Learning & Memory in Adult Male Rats |
| title_full_unstemmed | The Effect of Opium Dependency of Parent (s) on Offspring’s Spatial Learning & Memory in Adult Male Rats |
| title_short | The Effect of Opium Dependency of Parent (s) on Offspring’s Spatial Learning & Memory in Adult Male Rats |
| title_sort | effect of opium dependency of parent s on offspring s spatial learning memory in adult male rats |
| topic | Learning Memory Opium Parent (s) dependency Rat |
| url | http://ijbms.mums.ac.ir/pdf_782_942f2e385927e7f727cb9a09bf889578.html |
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