Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites

Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites

Zidovudine (AZT), the first drug approved by the US Food and Drug Administration for the treatment of human immunodeficiency virus (HIV) infection, is metabolized in the host cells to 5′-AZT triphosphate (AZT-TP) which inhibits HIV reverse transcriptase. As the pharmacokinetics of AZT and its phosph...

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Bibliographic Details
Main Authors: Lingli Mu, Rui Zhou, Fang Tang, Xingling Liu, Sanwang Li, Feifan Xie, Xiang Xie, Jie Peng, Peng Yu
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
LC–MS/MS
Zidovudine
Metabolites
Phosphates
hPBMCs
Pharmacokinetics
Intracellular kinetic
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383515001434

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