Long-term outcome and prognostic factors of single-dose Radioiodine Therapy in patients with Graves' disease
Background/purpose: Few studies exist investigating the effectiveness of radioiodine (RAI) therapy for hyperthyroidism patients in Asia. We herein investigated the real-world efficacy of single-dose RAI therapy in Taiwanese patients with Graves’ disease (GD). Methods: This is a retrospective study o...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-05-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664620300188 |
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| author | Yi-Ting Yang Jung-Fu Chen Shih-Chen Tung Ming-Chun Kuo Shao-Wen Weng Chen-Kai Chou Feng-Chih Shen Chih-Min Chang Chia-Jen Tsai Cheng-Feng Taso Pei-Wen Wang |
| author_facet | Yi-Ting Yang Jung-Fu Chen Shih-Chen Tung Ming-Chun Kuo Shao-Wen Weng Chen-Kai Chou Feng-Chih Shen Chih-Min Chang Chia-Jen Tsai Cheng-Feng Taso Pei-Wen Wang |
| author_sort | Yi-Ting Yang |
| collection | DOAJ |
| description | Background/purpose: Few studies exist investigating the effectiveness of radioiodine (RAI) therapy for hyperthyroidism patients in Asia. We herein investigated the real-world efficacy of single-dose RAI therapy in Taiwanese patients with Graves’ disease (GD). Methods: This is a retrospective study of 243 patients with GD recorded between 1989 and 2016 in a tertiary referral hospital. Eu- or hypothyroid after RAI therapy were defined as the successful group. Kaplan–Meier curve and cox-regression model were used for analysis of prognostic factors. Results: Of the 243 patients, 187 were females, with mean age of 46.9 ± 13.6 years. Most patients (63.8%) did not choose RAI as the first-line therapy. The median dose was 7 mCi, with a mean follow-up period of 107.1 ± 82.8 months. The overall success rate was 70.9%. Univariate analysis revealed calculated- or fixed-dose (P = 0.015), goiter size (P < 0.001), and RAI dose (P = 0.022) were the factors affecting RAI effectiveness, multivariate analysis indicated goiter size was the independent factor. Patients with grade 0–2 goiter had a higher success rate than patients with grade 3 goiter (HR = 2.1, 95%CI = 1.34–3.27, P = 0.001), although the former were treated with lower RAI dose than the latter (7.8 ± 3.2 mCi vs 8.8 ± 3.3 mCi, P = 0.049). However, if the grade 3 goiters became smaller within 3 months of therapy, the success rate was not inferior to grade 0–2 goiter. Conclusion: In Taiwan, RAI therapy for GD patients reached an overall success rate of 70.9%, with a median dose of 7 mCi. This study identified patients with grade 3 goiter need a more aggressive RAI regimen. |
| first_indexed | 2024-12-21T03:53:19Z |
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| id | doaj.art-ccdf09d04e81461c8b177994efe63162 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-21T03:53:19Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
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| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-ccdf09d04e81461c8b177994efe631622022-12-21T19:16:55ZengElsevierJournal of the Formosan Medical Association0929-66462020-05-011195925932Long-term outcome and prognostic factors of single-dose Radioiodine Therapy in patients with Graves' diseaseYi-Ting Yang0Jung-Fu Chen1Shih-Chen Tung2Ming-Chun Kuo3Shao-Wen Weng4Chen-Kai Chou5Feng-Chih Shen6Chih-Min Chang7Chia-Jen Tsai8Cheng-Feng Taso9Pei-Wen Wang10Division of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCDivision of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCDivision of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCDivision of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCDivision of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCDivision of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCDivision of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCDivision of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCDivision of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCDivision of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCCorresponding author. No. 123, Da-Pei Road., Niaosong Dist., Kaohsiung City, 833, Taiwan, ROC.; Division of Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROCBackground/purpose: Few studies exist investigating the effectiveness of radioiodine (RAI) therapy for hyperthyroidism patients in Asia. We herein investigated the real-world efficacy of single-dose RAI therapy in Taiwanese patients with Graves’ disease (GD). Methods: This is a retrospective study of 243 patients with GD recorded between 1989 and 2016 in a tertiary referral hospital. Eu- or hypothyroid after RAI therapy were defined as the successful group. Kaplan–Meier curve and cox-regression model were used for analysis of prognostic factors. Results: Of the 243 patients, 187 were females, with mean age of 46.9 ± 13.6 years. Most patients (63.8%) did not choose RAI as the first-line therapy. The median dose was 7 mCi, with a mean follow-up period of 107.1 ± 82.8 months. The overall success rate was 70.9%. Univariate analysis revealed calculated- or fixed-dose (P = 0.015), goiter size (P < 0.001), and RAI dose (P = 0.022) were the factors affecting RAI effectiveness, multivariate analysis indicated goiter size was the independent factor. Patients with grade 0–2 goiter had a higher success rate than patients with grade 3 goiter (HR = 2.1, 95%CI = 1.34–3.27, P = 0.001), although the former were treated with lower RAI dose than the latter (7.8 ± 3.2 mCi vs 8.8 ± 3.3 mCi, P = 0.049). However, if the grade 3 goiters became smaller within 3 months of therapy, the success rate was not inferior to grade 0–2 goiter. Conclusion: In Taiwan, RAI therapy for GD patients reached an overall success rate of 70.9%, with a median dose of 7 mCi. This study identified patients with grade 3 goiter need a more aggressive RAI regimen.http://www.sciencedirect.com/science/article/pii/S0929664620300188Graves' diseaseGoiter sizeOutcomeRadioiodine therapy |
| spellingShingle | Yi-Ting Yang Jung-Fu Chen Shih-Chen Tung Ming-Chun Kuo Shao-Wen Weng Chen-Kai Chou Feng-Chih Shen Chih-Min Chang Chia-Jen Tsai Cheng-Feng Taso Pei-Wen Wang Long-term outcome and prognostic factors of single-dose Radioiodine Therapy in patients with Graves' disease Journal of the Formosan Medical Association Graves' disease Goiter size Outcome Radioiodine therapy |
| title | Long-term outcome and prognostic factors of single-dose Radioiodine Therapy in patients with Graves' disease |
| title_full | Long-term outcome and prognostic factors of single-dose Radioiodine Therapy in patients with Graves' disease |
| title_fullStr | Long-term outcome and prognostic factors of single-dose Radioiodine Therapy in patients with Graves' disease |
| title_full_unstemmed | Long-term outcome and prognostic factors of single-dose Radioiodine Therapy in patients with Graves' disease |
| title_short | Long-term outcome and prognostic factors of single-dose Radioiodine Therapy in patients with Graves' disease |
| title_sort | long term outcome and prognostic factors of single dose radioiodine therapy in patients with graves disease |
| topic | Graves' disease Goiter size Outcome Radioiodine therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0929664620300188 |
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