A metal–organic framework nanocomposite with oxidation and near-infrared light cascade response for bacterial photothermal inactivation
Photothermal treatment is an effective and precise bacterial disinfection method that can reduce the occurrence of bacterial drug resistance. However, most conventional photothermal treatment strategies have the problem that the photothermal response range does not match the infection area. Herein,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.1044931/full |
| _version_ | 1811255193085411328 |
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| author | Christopher Dorma Momo Yuan Zhou Yuan Zhou Lanxin Li Lanxin Li Weisheng Zhu Luyao Wang Xingping Liu Wei Bing Zhijun Zhang |
| author_facet | Christopher Dorma Momo Yuan Zhou Yuan Zhou Lanxin Li Lanxin Li Weisheng Zhu Luyao Wang Xingping Liu Wei Bing Zhijun Zhang |
| author_sort | Christopher Dorma Momo |
| collection | DOAJ |
| description | Photothermal treatment is an effective and precise bacterial disinfection method that can reduce the occurrence of bacterial drug resistance. However, most conventional photothermal treatment strategies have the problem that the photothermal response range does not match the infection area. Herein, a metal–organic framework (MOF) nanocomposite responding to the oxidation state of the bacterial infection microenvironment was constructed for near-infrared (NIR) photothermal bacterial inactivation. In this strategy, the MOF was used as a nanocarrier to load tetramethylbenzidine (TMB) and horseradish peroxidase (HPR). The high oxidation state of the bacterial infection microenvironment can trigger the enzyme-catalyzed reaction of the nanocomposite, thereby generating oxidation products with the NIR photothermal effect for bacterial disinfection. The synthesis and characterization of the nanocomposite, oxidation state (H2O2) response effect, photothermal properties, and antibacterial activities were systematically studied. This study provides a new idea for building a precision treatment system for bacterial infection. |
| first_indexed | 2024-04-12T17:20:05Z |
| format | Article |
| id | doaj.art-ccdf2d421a204e859bb51cd8c5ed3e25 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-12T17:20:05Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Chemistry |
| spelling | doaj.art-ccdf2d421a204e859bb51cd8c5ed3e252022-12-22T03:23:31ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-10-011010.3389/fchem.2022.10449311044931A metal–organic framework nanocomposite with oxidation and near-infrared light cascade response for bacterial photothermal inactivationChristopher Dorma Momo0Yuan Zhou1Yuan Zhou2Lanxin Li3Lanxin Li4Weisheng Zhu5Luyao Wang6Xingping Liu7Wei Bing8Zhijun Zhang9Key Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, ChinaDepartment of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaCollege of Pharmacy, Hubei University of Traditional Chinese Medicine, Wuhan, ChinaKey Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, ChinaSchool of Chemistry and Life Science, Changchun University of Technology, Changchun, ChinaKey Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, ChinaSchool of Chemistry and Life Science, Changchun University of Technology, Changchun, ChinaSchool of Pharmaceutical Science, University of South China, Hengyang, ChinaSchool of Chemistry and Life Science, Changchun University of Technology, Changchun, ChinaKey Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, ChinaPhotothermal treatment is an effective and precise bacterial disinfection method that can reduce the occurrence of bacterial drug resistance. However, most conventional photothermal treatment strategies have the problem that the photothermal response range does not match the infection area. Herein, a metal–organic framework (MOF) nanocomposite responding to the oxidation state of the bacterial infection microenvironment was constructed for near-infrared (NIR) photothermal bacterial inactivation. In this strategy, the MOF was used as a nanocarrier to load tetramethylbenzidine (TMB) and horseradish peroxidase (HPR). The high oxidation state of the bacterial infection microenvironment can trigger the enzyme-catalyzed reaction of the nanocomposite, thereby generating oxidation products with the NIR photothermal effect for bacterial disinfection. The synthesis and characterization of the nanocomposite, oxidation state (H2O2) response effect, photothermal properties, and antibacterial activities were systematically studied. This study provides a new idea for building a precision treatment system for bacterial infection.https://www.frontiersin.org/articles/10.3389/fchem.2022.1044931/fullmetal–organic frameworkcascade responseantibacterial materialsphotothermal therapynanodrug |
| spellingShingle | Christopher Dorma Momo Yuan Zhou Yuan Zhou Lanxin Li Lanxin Li Weisheng Zhu Luyao Wang Xingping Liu Wei Bing Zhijun Zhang A metal–organic framework nanocomposite with oxidation and near-infrared light cascade response for bacterial photothermal inactivation Frontiers in Chemistry metal–organic framework cascade response antibacterial materials photothermal therapy nanodrug |
| title | A metal–organic framework nanocomposite with oxidation and near-infrared light cascade response for bacterial photothermal inactivation |
| title_full | A metal–organic framework nanocomposite with oxidation and near-infrared light cascade response for bacterial photothermal inactivation |
| title_fullStr | A metal–organic framework nanocomposite with oxidation and near-infrared light cascade response for bacterial photothermal inactivation |
| title_full_unstemmed | A metal–organic framework nanocomposite with oxidation and near-infrared light cascade response for bacterial photothermal inactivation |
| title_short | A metal–organic framework nanocomposite with oxidation and near-infrared light cascade response for bacterial photothermal inactivation |
| title_sort | metal organic framework nanocomposite with oxidation and near infrared light cascade response for bacterial photothermal inactivation |
| topic | metal–organic framework cascade response antibacterial materials photothermal therapy nanodrug |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.1044931/full |
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