Progress in the discovery of new bioactive substances from deep-sea associated fungi during 2020-2022
The marine environment can harbor millions of macro- and micro-organisms. These habitats have gained more attention as it was found they produce a plethora of novel secondary metabolites. Recently, marine-derived fungi have become the hotspot in drug discovery and development. Deep-sea-associated fu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Marine Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmars.2023.1232891/full |
| _version_ | 1797785265985552384 |
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| author | Zimin Wang Zimin Wang Mallique Qader Yufei Wang Fandong Kong Qi Wang Cong Wang |
| author_facet | Zimin Wang Zimin Wang Mallique Qader Yufei Wang Fandong Kong Qi Wang Cong Wang |
| author_sort | Zimin Wang |
| collection | DOAJ |
| description | The marine environment can harbor millions of macro- and micro-organisms. These habitats have gained more attention as it was found they produce a plethora of novel secondary metabolites. Recently, marine-derived fungi have become the hotspot in drug discovery and development. Deep-sea-associated fungi are an important group of marine fungi living in the ocean below 1000 m. The extreme living environment of high pressure and low temperature mean the deep-sea-associated fungi are difficult to collect but has resulted in the evolution of the special secondary metabolic genes in them. Although the vast majority of deep-sea fungi are undiscovered and very few natural products have been reported from them compared to the fungi derived from the near and shallow sea, they are still considered to be potential prolific sources of novel bioactive compounds that are of considerable interest for new drug leads. This review will expound on the sources of strains, chemical structures, and biological activity of 184 new natural products isolated from 46 deep-sea-associated fungi, which were reported from 2020-2022. |
| first_indexed | 2024-03-13T00:52:35Z |
| format | Article |
| id | doaj.art-cce033b6131d446a8ec778f452d7b950 |
| institution | Directory Open Access Journal |
| issn | 2296-7745 |
| language | English |
| last_indexed | 2024-03-13T00:52:35Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Marine Science |
| spelling | doaj.art-cce033b6131d446a8ec778f452d7b9502023-07-07T12:41:44ZengFrontiers Media S.A.Frontiers in Marine Science2296-77452023-07-011010.3389/fmars.2023.12328911232891Progress in the discovery of new bioactive substances from deep-sea associated fungi during 2020-2022Zimin Wang0Zimin Wang1Mallique Qader2Yufei Wang3Fandong Kong4Qi Wang5Cong Wang6Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Key Laboratory of Universities in Guangxi for Excavation and Development of Ancient Ethnomedicinal Recipes, Guangxi Minzu University, Nanning, ChinaDepartment of Pediatric Intensive Care Medicine, Hainan Women and Children’s Medical Center, Haikou, ChinaCollege of Pharmacy, Institute for Tuberculosis Research, University of Illinois Chicago, Chicago, IL, United StatesKey Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Key Laboratory of Universities in Guangxi for Excavation and Development of Ancient Ethnomedicinal Recipes, Guangxi Minzu University, Nanning, ChinaKey Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Key Laboratory of Universities in Guangxi for Excavation and Development of Ancient Ethnomedicinal Recipes, Guangxi Minzu University, Nanning, ChinaDepartment of Pediatric Intensive Care Medicine, Hainan Women and Children’s Medical Center, Haikou, ChinaKey Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Key Laboratory of Universities in Guangxi for Excavation and Development of Ancient Ethnomedicinal Recipes, Guangxi Minzu University, Nanning, ChinaThe marine environment can harbor millions of macro- and micro-organisms. These habitats have gained more attention as it was found they produce a plethora of novel secondary metabolites. Recently, marine-derived fungi have become the hotspot in drug discovery and development. Deep-sea-associated fungi are an important group of marine fungi living in the ocean below 1000 m. The extreme living environment of high pressure and low temperature mean the deep-sea-associated fungi are difficult to collect but has resulted in the evolution of the special secondary metabolic genes in them. Although the vast majority of deep-sea fungi are undiscovered and very few natural products have been reported from them compared to the fungi derived from the near and shallow sea, they are still considered to be potential prolific sources of novel bioactive compounds that are of considerable interest for new drug leads. This review will expound on the sources of strains, chemical structures, and biological activity of 184 new natural products isolated from 46 deep-sea-associated fungi, which were reported from 2020-2022.https://www.frontiersin.org/articles/10.3389/fmars.2023.1232891/fulldeep-sea fungichemical structuresmarine natural productsnew compoundsbioactivities |
| spellingShingle | Zimin Wang Zimin Wang Mallique Qader Yufei Wang Fandong Kong Qi Wang Cong Wang Progress in the discovery of new bioactive substances from deep-sea associated fungi during 2020-2022 Frontiers in Marine Science deep-sea fungi chemical structures marine natural products new compounds bioactivities |
| title | Progress in the discovery of new bioactive substances from deep-sea associated fungi during 2020-2022 |
| title_full | Progress in the discovery of new bioactive substances from deep-sea associated fungi during 2020-2022 |
| title_fullStr | Progress in the discovery of new bioactive substances from deep-sea associated fungi during 2020-2022 |
| title_full_unstemmed | Progress in the discovery of new bioactive substances from deep-sea associated fungi during 2020-2022 |
| title_short | Progress in the discovery of new bioactive substances from deep-sea associated fungi during 2020-2022 |
| title_sort | progress in the discovery of new bioactive substances from deep sea associated fungi during 2020 2022 |
| topic | deep-sea fungi chemical structures marine natural products new compounds bioactivities |
| url | https://www.frontiersin.org/articles/10.3389/fmars.2023.1232891/full |
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