Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study
Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients with...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-09-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2021.710504/full |
| _version_ | 1818588741305892864 |
|---|---|
| author | Xiaoyu Meng Xiaoyu Meng Huajie Zou Huajie Zou Danpei Li Danpei Li Peng Yu Peng Yu Li Huang Li Huang Jianhua Zhang Jianhua Zhang Wenjun Li Xuefeng Yu Xuefeng Yu |
| author_facet | Xiaoyu Meng Xiaoyu Meng Huajie Zou Huajie Zou Danpei Li Danpei Li Peng Yu Peng Yu Li Huang Li Huang Jianhua Zhang Jianhua Zhang Wenjun Li Xuefeng Yu Xuefeng Yu |
| author_sort | Xiaoyu Meng |
| collection | DOAJ |
| description | Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients with diabetes, especially in diabetic patients with albuminuria. This study aimed to investigate the association between circulating levels of ANGPTL8 and kidney function in the general population.Methods: The subjects were patients with renal dysfunction [estimated glomerular filtration rate (eGFR) <60/min/1.73 m2] from Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study (the REACTION study). Each case was matched by age, sex, and body mass index (BMI) with one control whose eGFR was ≥ 90 ml/min/1.73 m2. The case and control groups were compared using a paired t-test. Binary logistic regression analysis was used to calculate the odds ratio (OR) of renal dysfunction (RD).Results: Among 135 case-control pairs, circulating ANGPTL8 levels were elevated in patients with RD compared to control subjects [799.96 (410.12-1086.44) vs. 609.58 (365.13-740.06) pg/ml, p < 0.05]. Partial correlations showed that ANGPTL8 levels were negatively correlated with eGFR (r = −0.26, p < 0.05). Multivariable-adjusted binary logistic regression analysis showed that elevated ANGPTL8 levels were associated with an increased risk of RD (OR in quartile 4 vs. 1, 3.80; 95% CI, 1.71-8.41). Interestingly, the association between ANGPTL8 levels and RD was consistent with the overall findings in both nondiabetic individuals (OR, 1.44; 95% CI, 1.09 to 1.91) and diabetic patients (OR, 2.71; 95% CI, 1.13-6.49) in the subgroup analyses. Furthermore, the estimates for this association were also significant in females (OR, 2.12; 95% CI, 1.33-3.37), individuals aged > 60 years (OR, 1.55; 95% CI, 1.16-2.07), individuals with a BMI <24 (OR, 1.66; 95% CI, 1.16-2.39), and individuals without hyperlipidaemia (OR, 1.61; 95% CI, 1.16-2.23) (all p-values <0.05).Conclusion: Elevated circulating ANGPTL8 levels were associated with increased risk of RD in the general population, especially among females, individuals aged > 60 years, individuals with a BMI < 24, individuals without diabetes mellitus, individuals with diabetes mellitus (DM), and individuals without hyperlipidaemia. This finding implies that ANGPTL8 may play a role in the pathological process of RD. |
| first_indexed | 2024-12-16T09:29:34Z |
| format | Article |
| id | doaj.art-cce12f48f61947199fdc58407186e153 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-16T09:29:34Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-cce12f48f61947199fdc58407186e1532022-12-21T22:36:34ZengFrontiers Media S.A.Frontiers in Public Health2296-25652021-09-01910.3389/fpubh.2021.710504710504Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control StudyXiaoyu Meng0Xiaoyu Meng1Huajie Zou2Huajie Zou3Danpei Li4Danpei Li5Peng Yu6Peng Yu7Li Huang8Li Huang9Jianhua Zhang10Jianhua Zhang11Wenjun Li12Xuefeng Yu13Xuefeng Yu14Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaDivision of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaDivision of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaDivision of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaDivision of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaDivision of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaComputer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaBackground: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients with diabetes, especially in diabetic patients with albuminuria. This study aimed to investigate the association between circulating levels of ANGPTL8 and kidney function in the general population.Methods: The subjects were patients with renal dysfunction [estimated glomerular filtration rate (eGFR) <60/min/1.73 m2] from Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study (the REACTION study). Each case was matched by age, sex, and body mass index (BMI) with one control whose eGFR was ≥ 90 ml/min/1.73 m2. The case and control groups were compared using a paired t-test. Binary logistic regression analysis was used to calculate the odds ratio (OR) of renal dysfunction (RD).Results: Among 135 case-control pairs, circulating ANGPTL8 levels were elevated in patients with RD compared to control subjects [799.96 (410.12-1086.44) vs. 609.58 (365.13-740.06) pg/ml, p < 0.05]. Partial correlations showed that ANGPTL8 levels were negatively correlated with eGFR (r = −0.26, p < 0.05). Multivariable-adjusted binary logistic regression analysis showed that elevated ANGPTL8 levels were associated with an increased risk of RD (OR in quartile 4 vs. 1, 3.80; 95% CI, 1.71-8.41). Interestingly, the association between ANGPTL8 levels and RD was consistent with the overall findings in both nondiabetic individuals (OR, 1.44; 95% CI, 1.09 to 1.91) and diabetic patients (OR, 2.71; 95% CI, 1.13-6.49) in the subgroup analyses. Furthermore, the estimates for this association were also significant in females (OR, 2.12; 95% CI, 1.33-3.37), individuals aged > 60 years (OR, 1.55; 95% CI, 1.16-2.07), individuals with a BMI <24 (OR, 1.66; 95% CI, 1.16-2.39), and individuals without hyperlipidaemia (OR, 1.61; 95% CI, 1.16-2.23) (all p-values <0.05).Conclusion: Elevated circulating ANGPTL8 levels were associated with increased risk of RD in the general population, especially among females, individuals aged > 60 years, individuals with a BMI < 24, individuals without diabetes mellitus, individuals with diabetes mellitus (DM), and individuals without hyperlipidaemia. This finding implies that ANGPTL8 may play a role in the pathological process of RD.https://www.frontiersin.org/articles/10.3389/fpubh.2021.710504/fullANGPTL8eGFRrenal dysfunctioncreatininechronic kidney diseasecase-control study |
| spellingShingle | Xiaoyu Meng Xiaoyu Meng Huajie Zou Huajie Zou Danpei Li Danpei Li Peng Yu Peng Yu Li Huang Li Huang Jianhua Zhang Jianhua Zhang Wenjun Li Xuefeng Yu Xuefeng Yu Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study Frontiers in Public Health ANGPTL8 eGFR renal dysfunction creatinine chronic kidney disease case-control study |
| title | Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study |
| title_full | Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study |
| title_fullStr | Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study |
| title_full_unstemmed | Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study |
| title_short | Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study |
| title_sort | association of circulating angptl8 levels with renal dysfunction a case control study |
| topic | ANGPTL8 eGFR renal dysfunction creatinine chronic kidney disease case-control study |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2021.710504/full |
| work_keys_str_mv | AT xiaoyumeng associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT xiaoyumeng associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT huajiezou associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT huajiezou associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT danpeili associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT danpeili associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT pengyu associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT pengyu associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT lihuang associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT lihuang associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT jianhuazhang associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT jianhuazhang associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT wenjunli associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT xuefengyu associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy AT xuefengyu associationofcirculatingangptl8levelswithrenaldysfunctionacasecontrolstudy |