Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine
Arctium lappa L. is a medicinal edible homologous plant, commonly known as burdock or bardana, which belongs to the Asteraceae family. It is widely distributed throughout Northern Asia, Europe, and North America and has been utilized for hundreds of years. The roots, fruits, seeds, and leaves of A....
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222014937 |
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| author | Nermeen Yosri Sultan M. Alsharif Jianbo Xiao Syed G. Musharraf Chao Zhao Aamer Saeed Ruichang Gao Noha S. Said Alessandro Di Minno Maria Daglia Zhiming Guo Shaden A.M. Khalifa Hesham R. El-Seedi |
| author_facet | Nermeen Yosri Sultan M. Alsharif Jianbo Xiao Syed G. Musharraf Chao Zhao Aamer Saeed Ruichang Gao Noha S. Said Alessandro Di Minno Maria Daglia Zhiming Guo Shaden A.M. Khalifa Hesham R. El-Seedi |
| author_sort | Nermeen Yosri |
| collection | DOAJ |
| description | Arctium lappa L. is a medicinal edible homologous plant, commonly known as burdock or bardana, which belongs to the Asteraceae family. It is widely distributed throughout Northern Asia, Europe, and North America and has been utilized for hundreds of years. The roots, fruits, seeds, and leaves of A. lappa have been extensively used in traditional Chinese Medicine (TCM). A. lappa has attracted a great deal of attention due to its possession of highly recognized bioactive metabolites with significant therapeutic potential. Numerous pharmacological effects have been demonstrated in vitro and in vivo by A. lappa and its bioactive metabolites, including antimicrobial, anti-obesity, antioxidant, anticancer, anti-inflammatory, anti-diabetic, anti-allergic, antiviral, gastroprotective, hepatoprotective, and neuroprotective activities. Additionally, A. lappa has demonstrated considerable clinical efficacies and valuable applications in nanomedicine. Collectively, this review covers the properties of A. lappa and its bioactive metabolites, ethnopharmacology aspects, pharmacological effects, clinical trials, and applications in the field of nanomedicine. Hence, a significant attention should be paid to clinical trials and industrial applications of this plant with particular emphasis, on drug discovery and nanotechnology. |
| first_indexed | 2024-04-10T22:59:33Z |
| format | Article |
| id | doaj.art-cce20ee3b7814fec82a0cb2221efd606 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-10T22:59:33Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-cce20ee3b7814fec82a0cb2221efd6062023-01-14T04:25:47ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-02-01158114104Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicineNermeen Yosri0Sultan M. Alsharif1Jianbo Xiao2Syed G. Musharraf3Chao Zhao4Aamer Saeed5Ruichang Gao6Noha S. Said7Alessandro Di Minno8Maria Daglia9Zhiming Guo10Shaden A.M. Khalifa11Hesham R. El-Seedi12Chemistry Department of Medicinal and Aromatic Plants, Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef 62514, EgyptBiology Department, Faculty of Science, Taibah University, Al Madinah 887, Saudi ArabiaDepartment of Analytical Chemistry and Food Science, Faculty of Food Science and Technology, University of Vigo, Vigo, SpainH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, PakistanCollege of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaChemistry Department, Quaid-i-Azam University, Islamabad 45320, PakistanSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, EgyptDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy; CEINGE-Biotecnologie Avanzate, Naples 80131, ItalyDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, ChinaSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Molecular Biosciences, Stockholm University, The Wenner-GrenInstitute, SE-106 91 Stockholm, SwedenDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China; Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, Box 591, SE 751 24 Uppsala, Sweden; International Joint Research Laboratory of Intelligent Agriculture and Agri-products Processing (Jiangsu Education Department), Zhenjiang 212013, China; Corresponding author at: Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, Box 591, SE 751 24 Uppsala, Sweden.Arctium lappa L. is a medicinal edible homologous plant, commonly known as burdock or bardana, which belongs to the Asteraceae family. It is widely distributed throughout Northern Asia, Europe, and North America and has been utilized for hundreds of years. The roots, fruits, seeds, and leaves of A. lappa have been extensively used in traditional Chinese Medicine (TCM). A. lappa has attracted a great deal of attention due to its possession of highly recognized bioactive metabolites with significant therapeutic potential. Numerous pharmacological effects have been demonstrated in vitro and in vivo by A. lappa and its bioactive metabolites, including antimicrobial, anti-obesity, antioxidant, anticancer, anti-inflammatory, anti-diabetic, anti-allergic, antiviral, gastroprotective, hepatoprotective, and neuroprotective activities. Additionally, A. lappa has demonstrated considerable clinical efficacies and valuable applications in nanomedicine. Collectively, this review covers the properties of A. lappa and its bioactive metabolites, ethnopharmacology aspects, pharmacological effects, clinical trials, and applications in the field of nanomedicine. Hence, a significant attention should be paid to clinical trials and industrial applications of this plant with particular emphasis, on drug discovery and nanotechnology.http://www.sciencedirect.com/science/article/pii/S0753332222014937Arctium lappa L.Folk medicineBioactive constituentsPreclinical trialsClinical trialsNanomedicine |
| spellingShingle | Nermeen Yosri Sultan M. Alsharif Jianbo Xiao Syed G. Musharraf Chao Zhao Aamer Saeed Ruichang Gao Noha S. Said Alessandro Di Minno Maria Daglia Zhiming Guo Shaden A.M. Khalifa Hesham R. El-Seedi Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine Biomedicine & Pharmacotherapy Arctium lappa L. Folk medicine Bioactive constituents Preclinical trials Clinical trials Nanomedicine |
| title | Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine |
| title_full | Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine |
| title_fullStr | Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine |
| title_full_unstemmed | Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine |
| title_short | Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine |
| title_sort | arctium lappa burdock insights from ethnopharmacology potential chemical constituents clinical studies pharmacological utility and nanomedicine |
| topic | Arctium lappa L. Folk medicine Bioactive constituents Preclinical trials Clinical trials Nanomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222014937 |
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