Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study
Abstract Background Inflammatory bowel disease (IBD) is associated with lacrimal gland dysfunction and ocular inflammation. The objective of this research was to elucidate the temporal relationships between IBD, dry eye disease (DED), and corneal surface damage. Methods In a matched nationwide cohor...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-10-01
|
| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-023-03165-z |
| _version_ | 1797577403682258944 |
|---|---|
| author | Yi-Ting Ko Yu-Ming Wu Hsiang-Ling Wu Shih-Chung Lai Ying-Xiu Dai Tzeng-Ji Chen Yih-Giun Cherng Ying-Hsuan Tai Chia-Yu Kao |
| author_facet | Yi-Ting Ko Yu-Ming Wu Hsiang-Ling Wu Shih-Chung Lai Ying-Xiu Dai Tzeng-Ji Chen Yih-Giun Cherng Ying-Hsuan Tai Chia-Yu Kao |
| author_sort | Yi-Ting Ko |
| collection | DOAJ |
| description | Abstract Background Inflammatory bowel disease (IBD) is associated with lacrimal gland dysfunction and ocular inflammation. The objective of this research was to elucidate the temporal relationships between IBD, dry eye disease (DED), and corneal surface damage. Methods In a matched nationwide cohort study, we evaluated the risk of DED and corneal surface damage associated with IBD. Multivariable Cox proportional hazards regression analyses were implemented to estimate the risk of ocular complications. Results A total of 54,293 matched pairs were included for analyses. The median follow-up time was 8.3 years (interquartile range: 5.5 – 10.5). The period incidence of DED was 8.18 and 5.42 per 1000 person-years in the IBD and non-IBD groups, respectively. After adjusting for confounders, statistically significant associations were found between IBD and DED [adjusted hazard ratio (aHR): 1.43, 95% confidence interval (CI): 1.35 – 1.51, p < 0.0001], Sjögren’s syndrome-related (aHR: 1.67, 95% CI:1.46 – 1.90, p < 0.0001) and non-Sjögren’s syndrome-related subtypes (aHR: 1.38, 95% CI: 1.30 – 1.46, p < 0.0001). Furthermore, increased risks of corneal surface damage (aHR: 1.13, 95% CI: 1.03 – 1.24, p = 0.0094) among the patients with IBD were observed when compared with the controls. Other independent factors associated with corneal surface damage were age (aHR: 1.003), sex (male vs. female, aHR: 0.85), and monthly insurance premium (501–800 vs. 0–500 U.S. dollars, aHR: 1.45; ≥ 801 vs. 0–500 U.S. dollars, aHR: 1.32). Conclusions Our results suggested that IBD was an independent risk factor for DED and ocular surface damage. Clinical strategies are needed to prevent visual impairment or losses in these susceptible patients. |
| first_indexed | 2024-03-10T22:07:47Z |
| format | Article |
| id | doaj.art-cce21c269c1a443da2287d53986c6b0b |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-10T22:07:47Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-cce21c269c1a443da2287d53986c6b0b2023-11-19T12:45:23ZengBMCBMC Ophthalmology1471-24152023-10-0123111010.1186/s12886-023-03165-zInflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort studyYi-Ting Ko0Yu-Ming Wu1Hsiang-Ling Wu2Shih-Chung Lai3Ying-Xiu Dai4Tzeng-Ji Chen5Yih-Giun Cherng6Ying-Hsuan Tai7Chia-Yu Kao8Department of Anesthesiology, Shuang Ho Hospital, Taipei Medical UniversityDepartment of Anesthesiology, Shuang Ho Hospital, Taipei Medical UniversityDepartment of Anesthesiology, Taipei Veterans General Hospital 11217Department of Ophthalmology, Shuang Ho Hospital, Taipei Medical UniversitySchool of Medicine, National Yang Ming Chiao Tung UniversitySchool of Medicine, National Yang Ming Chiao Tung UniversityDepartment of Anesthesiology, Shuang Ho Hospital, Taipei Medical UniversityDepartment of Anesthesiology, Shuang Ho Hospital, Taipei Medical UniversityDepartment of Anesthesiology, Shuang Ho Hospital, Taipei Medical UniversityAbstract Background Inflammatory bowel disease (IBD) is associated with lacrimal gland dysfunction and ocular inflammation. The objective of this research was to elucidate the temporal relationships between IBD, dry eye disease (DED), and corneal surface damage. Methods In a matched nationwide cohort study, we evaluated the risk of DED and corneal surface damage associated with IBD. Multivariable Cox proportional hazards regression analyses were implemented to estimate the risk of ocular complications. Results A total of 54,293 matched pairs were included for analyses. The median follow-up time was 8.3 years (interquartile range: 5.5 – 10.5). The period incidence of DED was 8.18 and 5.42 per 1000 person-years in the IBD and non-IBD groups, respectively. After adjusting for confounders, statistically significant associations were found between IBD and DED [adjusted hazard ratio (aHR): 1.43, 95% confidence interval (CI): 1.35 – 1.51, p < 0.0001], Sjögren’s syndrome-related (aHR: 1.67, 95% CI:1.46 – 1.90, p < 0.0001) and non-Sjögren’s syndrome-related subtypes (aHR: 1.38, 95% CI: 1.30 – 1.46, p < 0.0001). Furthermore, increased risks of corneal surface damage (aHR: 1.13, 95% CI: 1.03 – 1.24, p = 0.0094) among the patients with IBD were observed when compared with the controls. Other independent factors associated with corneal surface damage were age (aHR: 1.003), sex (male vs. female, aHR: 0.85), and monthly insurance premium (501–800 vs. 0–500 U.S. dollars, aHR: 1.45; ≥ 801 vs. 0–500 U.S. dollars, aHR: 1.32). Conclusions Our results suggested that IBD was an independent risk factor for DED and ocular surface damage. Clinical strategies are needed to prevent visual impairment or losses in these susceptible patients.https://doi.org/10.1186/s12886-023-03165-zCrohn's diseaseKeratoconjunctivitis siccaPeripheral ulcerative keratitisUlcerative colitis |
| spellingShingle | Yi-Ting Ko Yu-Ming Wu Hsiang-Ling Wu Shih-Chung Lai Ying-Xiu Dai Tzeng-Ji Chen Yih-Giun Cherng Ying-Hsuan Tai Chia-Yu Kao Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study BMC Ophthalmology Crohn's disease Keratoconjunctivitis sicca Peripheral ulcerative keratitis Ulcerative colitis |
| title | Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study |
| title_full | Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study |
| title_fullStr | Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study |
| title_full_unstemmed | Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study |
| title_short | Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study |
| title_sort | inflammatory bowel disease and the associated risk of dry eye and ocular surface injury a nationwide matched cohort study |
| topic | Crohn's disease Keratoconjunctivitis sicca Peripheral ulcerative keratitis Ulcerative colitis |
| url | https://doi.org/10.1186/s12886-023-03165-z |
| work_keys_str_mv | AT yitingko inflammatoryboweldiseaseandtheassociatedriskofdryeyeandocularsurfaceinjuryanationwidematchedcohortstudy AT yumingwu inflammatoryboweldiseaseandtheassociatedriskofdryeyeandocularsurfaceinjuryanationwidematchedcohortstudy AT hsianglingwu inflammatoryboweldiseaseandtheassociatedriskofdryeyeandocularsurfaceinjuryanationwidematchedcohortstudy AT shihchunglai inflammatoryboweldiseaseandtheassociatedriskofdryeyeandocularsurfaceinjuryanationwidematchedcohortstudy AT yingxiudai inflammatoryboweldiseaseandtheassociatedriskofdryeyeandocularsurfaceinjuryanationwidematchedcohortstudy AT tzengjichen inflammatoryboweldiseaseandtheassociatedriskofdryeyeandocularsurfaceinjuryanationwidematchedcohortstudy AT yihgiuncherng inflammatoryboweldiseaseandtheassociatedriskofdryeyeandocularsurfaceinjuryanationwidematchedcohortstudy AT yinghsuantai inflammatoryboweldiseaseandtheassociatedriskofdryeyeandocularsurfaceinjuryanationwidematchedcohortstudy AT chiayukao inflammatoryboweldiseaseandtheassociatedriskofdryeyeandocularsurfaceinjuryanationwidematchedcohortstudy |