Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling

Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling

IntroductionSARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying differences in disease severity and to develop optimal va...

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Bibliographic Details
Main Authors: Felix Schreibing, Monica T. Hannani, Hyojin Kim, James S. Nagai, Fabio Ticconi, Eleanor Fewings, Tore Bleckwehl, Matthias Begemann, Natalia Torow, Christoph Kuppe, Ingo Kurth, Jennifer Kranz, Dario Frank, Teresa M. Anslinger, Patrick Ziegler, Thomas Kraus, Jürgen Enczmann, Vera Balz, Frank Windhofer, Paul Balfanz, Christian Kurts, Gernot Marx, Nikolaus Marx, Michael Dreher, Rebekka K. Schneider, Julio Saez-Rodriguez, Ivan Costa, Sikander Hayat, Rafael Kramann
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
scRNA-seq
scTCR-seq
immunoprofiling
CD8+ T cells
FCGR3A
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1066176/full

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