A role for radiotherapy in the management of advanced medullary thyroid carcinoma: the Mayo Clinic experience
Outcomes of external beam radiotherapy (EBRT) in advanced medullary thyroid carcinoma (MTC) are largely unknown. Retrospective review of data from patients with MTC, diagnosed from June 1, 1970, through December 31, 2007. Overall survival and locoregional tumor control rates were calculated. Sevente...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2013-07-01
|
| Series: | Rare Tumors |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/4776 |
| _version_ | 1818523470636515328 |
|---|---|
| author | Jason A. Call Jonathan S. Caudill Bryan McIver Robert L. Foote |
| author_facet | Jason A. Call Jonathan S. Caudill Bryan McIver Robert L. Foote |
| author_sort | Jason A. Call |
| collection | DOAJ |
| description | Outcomes of external beam radiotherapy (EBRT) in advanced medullary thyroid carcinoma (MTC) are largely unknown. Retrospective review of data from patients with MTC, diagnosed from June 1, 1970, through December 31, 2007. Overall survival and locoregional tumor control rates were calculated. Seventeen patients had adjuvant or palliative EBRT delivered to 41 sites. Six patients initially had adjuvant EBRT (median, 60.80 Gy); none had relapse in the treated area. Five patients with locoregional recurrence after surgery were treated (median, 59.40 Gy), and durable disease control was achieved in 3. Twelve patients received palliative EBRT to 29 sites of metastatic disease (median, 30.00 Gy), which provided sustained symptom relief at 45% of sites. Five- and ten- year overall survival rates were 44% and 19%, respectively. Adjuvant EBRT may be most effective for prevention of locoregional recurrence. EBRT may provide sustained control of advanced, metastatic disease in select patients. |
| first_indexed | 2024-12-11T05:45:18Z |
| format | Article |
| id | doaj.art-cce2e3ea5b004567b6274fe553abe8fa |
| institution | Directory Open Access Journal |
| issn | 2036-3605 2036-3613 |
| language | English |
| last_indexed | 2024-12-11T05:45:18Z |
| publishDate | 2013-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-cce2e3ea5b004567b6274fe553abe8fa2022-12-22T01:19:00ZengSAGE PublishingRare Tumors2036-36052036-36132013-07-0153e37e3710.4081/rt.2013.e372563A role for radiotherapy in the management of advanced medullary thyroid carcinoma: the Mayo Clinic experienceJason A. Call0Jonathan S. Caudill1Bryan McIver2Robert L. Foote3Department of Radiation Oncology, Mayo Clinic, Rochester, MNDepartment of Radiation Oncology, Mayo Clinic, Rochester, MNDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MNDepartment of Radiation Oncology, Mayo Clinic, Rochester, MNOutcomes of external beam radiotherapy (EBRT) in advanced medullary thyroid carcinoma (MTC) are largely unknown. Retrospective review of data from patients with MTC, diagnosed from June 1, 1970, through December 31, 2007. Overall survival and locoregional tumor control rates were calculated. Seventeen patients had adjuvant or palliative EBRT delivered to 41 sites. Six patients initially had adjuvant EBRT (median, 60.80 Gy); none had relapse in the treated area. Five patients with locoregional recurrence after surgery were treated (median, 59.40 Gy), and durable disease control was achieved in 3. Twelve patients received palliative EBRT to 29 sites of metastatic disease (median, 30.00 Gy), which provided sustained symptom relief at 45% of sites. Five- and ten- year overall survival rates were 44% and 19%, respectively. Adjuvant EBRT may be most effective for prevention of locoregional recurrence. EBRT may provide sustained control of advanced, metastatic disease in select patients.http://www.pagepress.org/journals/index.php/rt/article/view/4776medullary thyroid carcinoma, radiotherapy |
| spellingShingle | Jason A. Call Jonathan S. Caudill Bryan McIver Robert L. Foote A role for radiotherapy in the management of advanced medullary thyroid carcinoma: the Mayo Clinic experience Rare Tumors medullary thyroid carcinoma, radiotherapy |
| title | A role for radiotherapy in the management of advanced medullary thyroid carcinoma: the Mayo Clinic experience |
| title_full | A role for radiotherapy in the management of advanced medullary thyroid carcinoma: the Mayo Clinic experience |
| title_fullStr | A role for radiotherapy in the management of advanced medullary thyroid carcinoma: the Mayo Clinic experience |
| title_full_unstemmed | A role for radiotherapy in the management of advanced medullary thyroid carcinoma: the Mayo Clinic experience |
| title_short | A role for radiotherapy in the management of advanced medullary thyroid carcinoma: the Mayo Clinic experience |
| title_sort | role for radiotherapy in the management of advanced medullary thyroid carcinoma the mayo clinic experience |
| topic | medullary thyroid carcinoma, radiotherapy |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/4776 |
| work_keys_str_mv | AT jasonacall aroleforradiotherapyinthemanagementofadvancedmedullarythyroidcarcinomathemayoclinicexperience AT jonathanscaudill aroleforradiotherapyinthemanagementofadvancedmedullarythyroidcarcinomathemayoclinicexperience AT bryanmciver aroleforradiotherapyinthemanagementofadvancedmedullarythyroidcarcinomathemayoclinicexperience AT robertlfoote aroleforradiotherapyinthemanagementofadvancedmedullarythyroidcarcinomathemayoclinicexperience AT jasonacall roleforradiotherapyinthemanagementofadvancedmedullarythyroidcarcinomathemayoclinicexperience AT jonathanscaudill roleforradiotherapyinthemanagementofadvancedmedullarythyroidcarcinomathemayoclinicexperience AT bryanmciver roleforradiotherapyinthemanagementofadvancedmedullarythyroidcarcinomathemayoclinicexperience AT robertlfoote roleforradiotherapyinthemanagementofadvancedmedullarythyroidcarcinomathemayoclinicexperience |