Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases
Microglia play crucial roles in immune responses and contribute to fundamental biological processes within the central nervous system (CNS). In neurodegenerative diseases, microglia undergo functional changes and can have both protective and pathogenic roles. Microglia in the retina, as an extension...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1355557/full |
| _version_ | 1797341241132711936 |
|---|---|
| author | Fazeleh Etebar Fazeleh Etebar Damien G. Harkin Anthony R. White Samantha J. Dando Samantha J. Dando |
| author_facet | Fazeleh Etebar Fazeleh Etebar Damien G. Harkin Anthony R. White Samantha J. Dando Samantha J. Dando |
| author_sort | Fazeleh Etebar |
| collection | DOAJ |
| description | Microglia play crucial roles in immune responses and contribute to fundamental biological processes within the central nervous system (CNS). In neurodegenerative diseases, microglia undergo functional changes and can have both protective and pathogenic roles. Microglia in the retina, as an extension of the CNS, have also been shown to be affected in many neurological diseases. While our understanding of how microglia contribute to pathological conditions is incomplete, non-invasive in vivo imaging of brain and retinal microglia in living subjects could provide valuable insights into their role in the neurodegenerative diseases and open new avenues for diagnostic biomarkers. This mini-review provides an overview of the current brain and retinal imaging tools for studying microglia in vivo. We focus on microglia targets, the advantages and limitations of in vivo microglia imaging approaches, and applications for evaluating the pathogenesis of neurological conditions, such as Alzheimer’s disease and multiple sclerosis. |
| first_indexed | 2024-03-08T10:14:59Z |
| format | Article |
| id | doaj.art-cce4b4ffc8aa4e5581eefb2ec4e26f4b |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-03-08T10:14:59Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-cce4b4ffc8aa4e5581eefb2ec4e26f4b2024-01-29T04:22:33ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-01-011810.3389/fncel.2024.13555571355557Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseasesFazeleh Etebar0Fazeleh Etebar1Damien G. Harkin2Anthony R. White3Samantha J. Dando4Samantha J. Dando5Centre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD, AustraliaMental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Herston, QLD, AustraliaCentre for Vision and Eye Research, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD, AustraliaMental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Herston, QLD, AustraliaCentre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD, AustraliaCentre for Vision and Eye Research, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD, AustraliaMicroglia play crucial roles in immune responses and contribute to fundamental biological processes within the central nervous system (CNS). In neurodegenerative diseases, microglia undergo functional changes and can have both protective and pathogenic roles. Microglia in the retina, as an extension of the CNS, have also been shown to be affected in many neurological diseases. While our understanding of how microglia contribute to pathological conditions is incomplete, non-invasive in vivo imaging of brain and retinal microglia in living subjects could provide valuable insights into their role in the neurodegenerative diseases and open new avenues for diagnostic biomarkers. This mini-review provides an overview of the current brain and retinal imaging tools for studying microglia in vivo. We focus on microglia targets, the advantages and limitations of in vivo microglia imaging approaches, and applications for evaluating the pathogenesis of neurological conditions, such as Alzheimer’s disease and multiple sclerosis.https://www.frontiersin.org/articles/10.3389/fncel.2024.1355557/fullmicroglianon-invasive in vivo imagingpositron emission tomographyoptical coherence tomographyconfocal scanning laser ophthalmoscopyadaptive optics |
| spellingShingle | Fazeleh Etebar Fazeleh Etebar Damien G. Harkin Anthony R. White Samantha J. Dando Samantha J. Dando Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases Frontiers in Cellular Neuroscience microglia non-invasive in vivo imaging positron emission tomography optical coherence tomography confocal scanning laser ophthalmoscopy adaptive optics |
| title | Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases |
| title_full | Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases |
| title_fullStr | Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases |
| title_full_unstemmed | Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases |
| title_short | Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases |
| title_sort | non invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases |
| topic | microglia non-invasive in vivo imaging positron emission tomography optical coherence tomography confocal scanning laser ophthalmoscopy adaptive optics |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1355557/full |
| work_keys_str_mv | AT fazelehetebar noninvasiveinvivoimagingofbrainandretinalmicrogliainneurodegenerativediseases AT fazelehetebar noninvasiveinvivoimagingofbrainandretinalmicrogliainneurodegenerativediseases AT damiengharkin noninvasiveinvivoimagingofbrainandretinalmicrogliainneurodegenerativediseases AT anthonyrwhite noninvasiveinvivoimagingofbrainandretinalmicrogliainneurodegenerativediseases AT samanthajdando noninvasiveinvivoimagingofbrainandretinalmicrogliainneurodegenerativediseases AT samanthajdando noninvasiveinvivoimagingofbrainandretinalmicrogliainneurodegenerativediseases |