Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis
AbstractMagnetic resonance imaging (MRI) is an essential tool for the diagnosis of atherosclerosis, a chronic cardiovascular disease. MRI primarily uses superparamagnetic iron oxide (SPIO) as a contrast agent. However, SPIO integrated with therapeutic drugs has rarely been studied. In this study, we...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1699823 |
| _version_ | 1797788755793281024 |
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| author | Shuihua Zhang Wan Xu Peng Gao Wenli Chen Quan Zhou |
| author_facet | Shuihua Zhang Wan Xu Peng Gao Wenli Chen Quan Zhou |
| author_sort | Shuihua Zhang |
| collection | DOAJ |
| description | AbstractMagnetic resonance imaging (MRI) is an essential tool for the diagnosis of atherosclerosis, a chronic cardiovascular disease. MRI primarily uses superparamagnetic iron oxide (SPIO) as a contrast agent. However, SPIO integrated with therapeutic drugs has rarely been studied. In this study, we explored biocompatible paramagnetic iron-oxide nanoparticles (NPs) in a complex with low pH-sensitive cyclodextrin for the diagnostic imaging and treatment of atherosclerosis. The NPs were conjugated with profilin-1 antibody (PFN1) to specifically target vascular smooth muscle cells (VSMCs) in the atherosclerotic plaque and integrated with the anti-inflammatory drug, rapamycin. The PFN1-CD-MNPs were easily binded to the VSMCs, indicating their good biocompatibility and low renal toxicity over the long term. Ex vivo near-infrared fluorescence (NIRF) imaging and in vivo MRI indicated the accumulation of PFN1-CD-MNPs in the atherosclerotic plaque. The RAP@PFN1-CD-MNPs alleviated the progression of arteriosclerosis. Thus, PFN1-CD-MNPs served not only as multifunctional imaging probes but also as nanovehicles for the treatment of atherosclerosis. |
| first_indexed | 2024-03-13T01:41:06Z |
| format | Article |
| id | doaj.art-cce71a4f428849f1aa2b3bf8fdaf4f35 |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-03-13T01:41:06Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-cce71a4f428849f1aa2b3bf8fdaf4f352023-07-03T14:04:56ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2020-01-0148116917910.1080/21691401.2019.1699823Construction of dual nanomedicines for the imaging and alleviation of atherosclerosisShuihua Zhang0Wan Xu1Peng Gao2Wenli Chen3Quan Zhou4Department of Radiology, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Guangzhou, ChinaMinistry of Education Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, ChinaMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, ChinaMinistry of Education Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, ChinaDepartment of Radiology, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Guangzhou, ChinaAbstractMagnetic resonance imaging (MRI) is an essential tool for the diagnosis of atherosclerosis, a chronic cardiovascular disease. MRI primarily uses superparamagnetic iron oxide (SPIO) as a contrast agent. However, SPIO integrated with therapeutic drugs has rarely been studied. In this study, we explored biocompatible paramagnetic iron-oxide nanoparticles (NPs) in a complex with low pH-sensitive cyclodextrin for the diagnostic imaging and treatment of atherosclerosis. The NPs were conjugated with profilin-1 antibody (PFN1) to specifically target vascular smooth muscle cells (VSMCs) in the atherosclerotic plaque and integrated with the anti-inflammatory drug, rapamycin. The PFN1-CD-MNPs were easily binded to the VSMCs, indicating their good biocompatibility and low renal toxicity over the long term. Ex vivo near-infrared fluorescence (NIRF) imaging and in vivo MRI indicated the accumulation of PFN1-CD-MNPs in the atherosclerotic plaque. The RAP@PFN1-CD-MNPs alleviated the progression of arteriosclerosis. Thus, PFN1-CD-MNPs served not only as multifunctional imaging probes but also as nanovehicles for the treatment of atherosclerosis.https://www.tandfonline.com/doi/10.1080/21691401.2019.1699823Molecular imagingatherosclerosisnanotherapyprofilin-1 |
| spellingShingle | Shuihua Zhang Wan Xu Peng Gao Wenli Chen Quan Zhou Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis Artificial Cells, Nanomedicine, and Biotechnology Molecular imaging atherosclerosis nanotherapy profilin-1 |
| title | Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis |
| title_full | Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis |
| title_fullStr | Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis |
| title_full_unstemmed | Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis |
| title_short | Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis |
| title_sort | construction of dual nanomedicines for the imaging and alleviation of atherosclerosis |
| topic | Molecular imaging atherosclerosis nanotherapy profilin-1 |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1699823 |
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