Chitosan chelated Fe3+ nanocomposite for enhanced biomedical and environmental applications
AbstractChitosan, a biopolymer known for its biocompatibility, biodegradability, and chemical adaptability, has attracted significant attention in scientific research. Chitosan-metal nanocomposites represent an emerging area of exploration. Among these, Chitosan-Fe nanocomposite has gained prominenc...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Nanocomposites |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20550324.2023.2281833 |
| _version_ | 1797387082399744000 |
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| author | Rutuja Gumathannavar Anil Thormothe Pankhudi Bhutada Mandar M. Shirolkar Atul Kulkarni Santosh Koratkar |
| author_facet | Rutuja Gumathannavar Anil Thormothe Pankhudi Bhutada Mandar M. Shirolkar Atul Kulkarni Santosh Koratkar |
| author_sort | Rutuja Gumathannavar |
| collection | DOAJ |
| description | AbstractChitosan, a biopolymer known for its biocompatibility, biodegradability, and chemical adaptability, has attracted significant attention in scientific research. Chitosan-metal nanocomposites represent an emerging area of exploration. Among these, Chitosan-Fe nanocomposite has gained prominence due to its various applications, including photoremediation, bioimaging, and drug delivery systems. In this study, we delved into the synthesis and physicochemical properties of Chitosan-Fe nanocomposites. These nanocomposites exhibited a spherical structure with active binding sites that allowed for the functionalization of Fe3+ ions on their surface. Density functional theory simulations corroborated this alteration, demonstrating changes in surface charge properties resulting in increased mechanical strength. A key finding of this study is the enhanced antibacterial activity exhibited by the Cs-Fe nanocomposites against both Escherichia coli (62.5 µg/mL) and Staphylococcus aureus (125.25 µg/mL), surpassing that of bare Chitosan nanoparticles. Furthermore, our investigation confirms the therapeutic safety of the Chitosan-Fe nanocomposite. The cell viability calculated by MTT assay and accepted therapeutic dose concentration for CS-Fe NC was 125 ug/mL whereas for CSNP < 15.62 µg/mL. This underscores the nanocomposite’s potential in biomedical applications. In addition to its biomedical promise, the Chitosan-Fe nanocomposite also demonstrates remarkable potential in environmental remediation, particularly in the removal of hexavalent chromium. |
| first_indexed | 2024-03-08T22:18:43Z |
| format | Article |
| id | doaj.art-cce7a757d2ae4a19bbd784247c682e93 |
| institution | Directory Open Access Journal |
| issn | 2055-0324 2055-0332 |
| language | English |
| last_indexed | 2024-03-08T22:18:43Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Nanocomposites |
| spelling | doaj.art-cce7a757d2ae4a19bbd784247c682e932023-12-18T16:58:21ZengTaylor & Francis GroupNanocomposites2055-03242055-03322023-12-019115917010.1080/20550324.2023.2281833Chitosan chelated Fe3+ nanocomposite for enhanced biomedical and environmental applicationsRutuja Gumathannavar0Anil Thormothe1Pankhudi Bhutada2Mandar M. Shirolkar3Atul Kulkarni4Santosh Koratkar5Symbiosis Centre for Nanoscience and Nanotechnology, Symbiosis International University, Lavale, Pune, IndiaSymbiosis School of Biological Science, Symbiosis International University, Lavale, Pune, IndiaSymbiosis School of Biological Science, Symbiosis International University, Lavale, Pune, IndiaSymbiosis Centre for Nanoscience and Nanotechnology, Symbiosis International University, Lavale, Pune, IndiaSymbiosis Centre for Nanoscience and Nanotechnology, Symbiosis International University, Lavale, Pune, IndiaSymbiosis School of Biological Science, Symbiosis International University, Lavale, Pune, IndiaAbstractChitosan, a biopolymer known for its biocompatibility, biodegradability, and chemical adaptability, has attracted significant attention in scientific research. Chitosan-metal nanocomposites represent an emerging area of exploration. Among these, Chitosan-Fe nanocomposite has gained prominence due to its various applications, including photoremediation, bioimaging, and drug delivery systems. In this study, we delved into the synthesis and physicochemical properties of Chitosan-Fe nanocomposites. These nanocomposites exhibited a spherical structure with active binding sites that allowed for the functionalization of Fe3+ ions on their surface. Density functional theory simulations corroborated this alteration, demonstrating changes in surface charge properties resulting in increased mechanical strength. A key finding of this study is the enhanced antibacterial activity exhibited by the Cs-Fe nanocomposites against both Escherichia coli (62.5 µg/mL) and Staphylococcus aureus (125.25 µg/mL), surpassing that of bare Chitosan nanoparticles. Furthermore, our investigation confirms the therapeutic safety of the Chitosan-Fe nanocomposite. The cell viability calculated by MTT assay and accepted therapeutic dose concentration for CS-Fe NC was 125 ug/mL whereas for CSNP < 15.62 µg/mL. This underscores the nanocomposite’s potential in biomedical applications. In addition to its biomedical promise, the Chitosan-Fe nanocomposite also demonstrates remarkable potential in environmental remediation, particularly in the removal of hexavalent chromium.https://www.tandfonline.com/doi/10.1080/20550324.2023.2281833ChitosanCS-Fe nanocompositebiocompatibilityantibacterial effectDFT simulationcell viability |
| spellingShingle | Rutuja Gumathannavar Anil Thormothe Pankhudi Bhutada Mandar M. Shirolkar Atul Kulkarni Santosh Koratkar Chitosan chelated Fe3+ nanocomposite for enhanced biomedical and environmental applications Nanocomposites Chitosan CS-Fe nanocomposite biocompatibility antibacterial effect DFT simulation cell viability |
| title | Chitosan chelated Fe3+ nanocomposite for enhanced biomedical and environmental applications |
| title_full | Chitosan chelated Fe3+ nanocomposite for enhanced biomedical and environmental applications |
| title_fullStr | Chitosan chelated Fe3+ nanocomposite for enhanced biomedical and environmental applications |
| title_full_unstemmed | Chitosan chelated Fe3+ nanocomposite for enhanced biomedical and environmental applications |
| title_short | Chitosan chelated Fe3+ nanocomposite for enhanced biomedical and environmental applications |
| title_sort | chitosan chelated fe3 nanocomposite for enhanced biomedical and environmental applications |
| topic | Chitosan CS-Fe nanocomposite biocompatibility antibacterial effect DFT simulation cell viability |
| url | https://www.tandfonline.com/doi/10.1080/20550324.2023.2281833 |
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