GIANT CELL TUMOR OF BONE: A MULTICENTER EPIDEMIOLOGICAL STUDY IN BRAZIL
ABSTRACT Introduction: Giant cell tumor of bone (GCTB) mainly affects young adults’ long bone epiphyses, threatening bone strength and joint function. Surgery is the primary treatment, although post-surgery recurrence is significant. This study analyzes patient profiles, treatments, and outcomes fo...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Ortopedia e Traumatologia
2024-03-01
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| Series: | Acta Ortopédica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522024000100800&tlng=en |
| _version_ | 1797244730177748992 |
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| author | Ricardo Gehrke Becker Carlos Roberto Galia Julie Francine Cerutti Santos Pestilho Bruno Pereira Antunes André Mathias Baptista Alex Guedes |
| author_facet | Ricardo Gehrke Becker Carlos Roberto Galia Julie Francine Cerutti Santos Pestilho Bruno Pereira Antunes André Mathias Baptista Alex Guedes |
| author_sort | Ricardo Gehrke Becker |
| collection | DOAJ |
| description | ABSTRACT Introduction: Giant cell tumor of bone (GCTB) mainly affects young adults’ long bone epiphyses, threatening bone strength and joint function. Surgery is the primary treatment, although post-surgery recurrence is significant. This study analyzes patient profiles, treatments, and outcomes for GCTB in Brazil. Methods: We retrospectively assessed local recurrence, metastasis, and treatment approaches in 643 GCTB patients across 16 Brazilian centers (1989-2021), considering regional differences. Results: 5.1% (n=33) developed pulmonary metastases, 14.3% (n=92) had pathological fractures, and the local recurrence rate was 18.2% (n=114). Higher rates of pulmonary metastases (12.1%) and advanced tumors (Campanacci III, 88.9%) were noted in lower-income North and Northeast regions. The North also had more pathological fractures (33.3%), extensive resections (61.1%), and amputations (27.8%). These regions faced longer surgical delays (36-39 days) than the South and Southeast (27-33 days). Conclusions: Our findings corroborate international data, underscoring regional disparities in Brazil that may lead to worse outcomes in disadvantaged areas. This highlights the need for improved orthopedic oncology care in Brazil’s economically and structurally challenged regions. Level of Evidence III; Retrospective Cohort. |
| first_indexed | 2024-04-24T19:15:39Z |
| format | Article |
| id | doaj.art-cce8f091f6dd43efbb67f8a3172283de |
| institution | Directory Open Access Journal |
| issn | 1413-7852 |
| language | English |
| last_indexed | 2024-04-24T19:15:39Z |
| publishDate | 2024-03-01 |
| publisher | Sociedade Brasileira de Ortopedia e Traumatologia |
| record_format | Article |
| series | Acta Ortopédica Brasileira |
| spelling | doaj.art-cce8f091f6dd43efbb67f8a3172283de2024-03-26T07:39:21ZengSociedade Brasileira de Ortopedia e TraumatologiaActa Ortopédica Brasileira1413-78522024-03-0132110.1590/1413-785220243201e273066GIANT CELL TUMOR OF BONE: A MULTICENTER EPIDEMIOLOGICAL STUDY IN BRAZILRicardo Gehrke Beckerhttps://orcid.org/0000-0003-2629-9752Carlos Roberto Galiahttps://orcid.org/0000-0003-1731-4543Julie Francine Cerutti Santos Pestilhohttps://orcid.org/0000-0003-3630-8595Bruno Pereira Antuneshttps://orcid.org/0000-0003-1102-3083André Mathias Baptistahttps://orcid.org/0000-0002-0830-4602Alex Guedeshttps://orcid.org/0000-0001-7013-7107ABSTRACT Introduction: Giant cell tumor of bone (GCTB) mainly affects young adults’ long bone epiphyses, threatening bone strength and joint function. Surgery is the primary treatment, although post-surgery recurrence is significant. This study analyzes patient profiles, treatments, and outcomes for GCTB in Brazil. Methods: We retrospectively assessed local recurrence, metastasis, and treatment approaches in 643 GCTB patients across 16 Brazilian centers (1989-2021), considering regional differences. Results: 5.1% (n=33) developed pulmonary metastases, 14.3% (n=92) had pathological fractures, and the local recurrence rate was 18.2% (n=114). Higher rates of pulmonary metastases (12.1%) and advanced tumors (Campanacci III, 88.9%) were noted in lower-income North and Northeast regions. The North also had more pathological fractures (33.3%), extensive resections (61.1%), and amputations (27.8%). These regions faced longer surgical delays (36-39 days) than the South and Southeast (27-33 days). Conclusions: Our findings corroborate international data, underscoring regional disparities in Brazil that may lead to worse outcomes in disadvantaged areas. This highlights the need for improved orthopedic oncology care in Brazil’s economically and structurally challenged regions. Level of Evidence III; Retrospective Cohort.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522024000100800&tlng=enBone NeoplasmsGiant Cell Tumor of BoneCurettageRecurrence |
| spellingShingle | Ricardo Gehrke Becker Carlos Roberto Galia Julie Francine Cerutti Santos Pestilho Bruno Pereira Antunes André Mathias Baptista Alex Guedes GIANT CELL TUMOR OF BONE: A MULTICENTER EPIDEMIOLOGICAL STUDY IN BRAZIL Acta Ortopédica Brasileira Bone Neoplasms Giant Cell Tumor of Bone Curettage Recurrence |
| title | GIANT CELL TUMOR OF BONE: A MULTICENTER EPIDEMIOLOGICAL STUDY IN BRAZIL |
| title_full | GIANT CELL TUMOR OF BONE: A MULTICENTER EPIDEMIOLOGICAL STUDY IN BRAZIL |
| title_fullStr | GIANT CELL TUMOR OF BONE: A MULTICENTER EPIDEMIOLOGICAL STUDY IN BRAZIL |
| title_full_unstemmed | GIANT CELL TUMOR OF BONE: A MULTICENTER EPIDEMIOLOGICAL STUDY IN BRAZIL |
| title_short | GIANT CELL TUMOR OF BONE: A MULTICENTER EPIDEMIOLOGICAL STUDY IN BRAZIL |
| title_sort | giant cell tumor of bone a multicenter epidemiological study in brazil |
| topic | Bone Neoplasms Giant Cell Tumor of Bone Curettage Recurrence |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522024000100800&tlng=en |
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