Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicul...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/9/1974 |
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| author | Sherin Saheera Ajay Godwin Potnuri Prasanna Krishnamurthy |
| author_facet | Sherin Saheera Ajay Godwin Potnuri Prasanna Krishnamurthy |
| author_sort | Sherin Saheera |
| collection | DOAJ |
| description | Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular structures (exosomes) range from 30 to 140 nm and are present in various biological fluids such as saliva, plasma, urine etc. These cargo-laden extracellular vesicles arise from endosome-derived multivesicular bodies and are known to carry proteins and nucleic acids. Exosomes are involved in multiple physiological and pathological processes, including cellular senescence. Exosomes mediate signaling crosstalk and play a critical role in cell–cell communications. Exosomes have evolved as potential biomarkers for aging-related diseases. Aging, a physiological process, involves a progressive decline of function of organs with a loss of homeostasis and increasing probability of illness and death. The review focuses on the classic view of exosome biogenesis, biology, and age-associated changes. Owing to their ability to transport biological information among cells, the review also discusses the interplay of senescent cell-derived exosomes with the aging process, including the susceptibility of the aging population to COVID-19 infections. |
| first_indexed | 2024-03-10T16:48:13Z |
| format | Article |
| id | doaj.art-cceb9969bd424499abf3b77a07f6cba3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T16:48:13Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-cceb9969bd424499abf3b77a07f6cba32023-11-20T11:28:36ZengMDPI AGCells2073-44092020-08-0199197410.3390/cells9091974Nano-Vesicle (Mis)Communication in Senescence-Related PathologiesSherin Saheera0Ajay Godwin Potnuri1Prasanna Krishnamurthy2Department of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USADepartment of Animal Physiology, Indian Council for Medical Research—National Animal Resource Facility for Biomedical Research, Genome Valley, Shamirpet, Hyderabad, Telangana 500078, IndiaDepartment of Biomedical Engineering, School of Medicine and School of Engineering, The University of Alabama at Birmingham, 1675 University Blvd, Volker Hall G094, Birmingham, AL 35294, USAExtracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular structures (exosomes) range from 30 to 140 nm and are present in various biological fluids such as saliva, plasma, urine etc. These cargo-laden extracellular vesicles arise from endosome-derived multivesicular bodies and are known to carry proteins and nucleic acids. Exosomes are involved in multiple physiological and pathological processes, including cellular senescence. Exosomes mediate signaling crosstalk and play a critical role in cell–cell communications. Exosomes have evolved as potential biomarkers for aging-related diseases. Aging, a physiological process, involves a progressive decline of function of organs with a loss of homeostasis and increasing probability of illness and death. The review focuses on the classic view of exosome biogenesis, biology, and age-associated changes. Owing to their ability to transport biological information among cells, the review also discusses the interplay of senescent cell-derived exosomes with the aging process, including the susceptibility of the aging population to COVID-19 infections.https://www.mdpi.com/2073-4409/9/9/1974exosomesagingextracellular vesiclesmiRNACOVID-19 |
| spellingShingle | Sherin Saheera Ajay Godwin Potnuri Prasanna Krishnamurthy Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies Cells exosomes aging extracellular vesicles miRNA COVID-19 |
| title | Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies |
| title_full | Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies |
| title_fullStr | Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies |
| title_full_unstemmed | Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies |
| title_short | Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies |
| title_sort | nano vesicle mis communication in senescence related pathologies |
| topic | exosomes aging extracellular vesicles miRNA COVID-19 |
| url | https://www.mdpi.com/2073-4409/9/9/1974 |
| work_keys_str_mv | AT sherinsaheera nanovesiclemiscommunicationinsenescencerelatedpathologies AT ajaygodwinpotnuri nanovesiclemiscommunicationinsenescencerelatedpathologies AT prasannakrishnamurthy nanovesiclemiscommunicationinsenescencerelatedpathologies |