Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.
This study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg(9)-BK production, nitric oxide release (NO) and blood pressure (BP) response after moderate-intensity aerobic exercise performed by individuals with and without type 2 diabetes. Ten subjects with type 2 d...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24265812/?tool=EBI |
| _version_ | 1818459636865433600 |
|---|---|
| author | Herbert Gustavo Simões Ricardo Yukio Asano Marcelo Magalhães Sales Rodrigo Alberto Vieira Browne Gisela Arsa Daisy Motta-Santos Guilherme Morais Puga Laila Cândida de Jesus Lima Carmen Sílvia Grubert Campbell Octavio Luiz Franco |
| author_facet | Herbert Gustavo Simões Ricardo Yukio Asano Marcelo Magalhães Sales Rodrigo Alberto Vieira Browne Gisela Arsa Daisy Motta-Santos Guilherme Morais Puga Laila Cândida de Jesus Lima Carmen Sílvia Grubert Campbell Octavio Luiz Franco |
| author_sort | Herbert Gustavo Simões |
| collection | DOAJ |
| description | This study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg(9)-BK production, nitric oxide release (NO) and blood pressure (BP) response after moderate-intensity aerobic exercise performed by individuals with and without type 2 diabetes. Ten subjects with type 2 diabetes (T2D) and 10 without type 2 diabetes (ND) underwent three sessions: 1) maximal incremental test on cycle ergometer to determine lactate threshold (LT); 2) 20-min of constant-load exercise on cycle ergometer, at 90% LT and; 3) control session. BP and oxygen uptake were measured at rest and at 15, 30 and 45 min post-exercise. Venous blood samples were collected at 15 and 45 minutes of the recovery period for further analysis of PKA, BK and DesArg(9)-BK. Nitrite plus nitrate (NOx) was analyzed at 15 minutes post exercise. The ND group presented post-exercise hypotension (PEH) of systolic blood pressure and mean arterial pressure on the 90% LT session but T2D group did not. Plasma NOx increased ~24.4% for ND and ~13.8% for T2D group 15 min after the exercise session. Additionally, only ND individuals showed increases in PKA and BK in response to exercise and only T2D group showed increased DesArg(9)-BK production. It was concluded that T2D individuals presented lower PKA, BK and NOx release as well as higher DesArg(9)-BK production and reduced PEH in relation to ND participants after a single exercise session. |
| first_indexed | 2024-12-14T23:17:31Z |
| format | Article |
| id | doaj.art-cced38825bc7417d9928673ac8ae3949 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T23:17:31Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cced38825bc7417d9928673ac8ae39492022-12-21T22:44:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e8034810.1371/journal.pone.0080348Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.Herbert Gustavo SimõesRicardo Yukio AsanoMarcelo Magalhães SalesRodrigo Alberto Vieira BrowneGisela ArsaDaisy Motta-SantosGuilherme Morais PugaLaila Cândida de Jesus LimaCarmen Sílvia Grubert CampbellOctavio Luiz FrancoThis study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg(9)-BK production, nitric oxide release (NO) and blood pressure (BP) response after moderate-intensity aerobic exercise performed by individuals with and without type 2 diabetes. Ten subjects with type 2 diabetes (T2D) and 10 without type 2 diabetes (ND) underwent three sessions: 1) maximal incremental test on cycle ergometer to determine lactate threshold (LT); 2) 20-min of constant-load exercise on cycle ergometer, at 90% LT and; 3) control session. BP and oxygen uptake were measured at rest and at 15, 30 and 45 min post-exercise. Venous blood samples were collected at 15 and 45 minutes of the recovery period for further analysis of PKA, BK and DesArg(9)-BK. Nitrite plus nitrate (NOx) was analyzed at 15 minutes post exercise. The ND group presented post-exercise hypotension (PEH) of systolic blood pressure and mean arterial pressure on the 90% LT session but T2D group did not. Plasma NOx increased ~24.4% for ND and ~13.8% for T2D group 15 min after the exercise session. Additionally, only ND individuals showed increases in PKA and BK in response to exercise and only T2D group showed increased DesArg(9)-BK production. It was concluded that T2D individuals presented lower PKA, BK and NOx release as well as higher DesArg(9)-BK production and reduced PEH in relation to ND participants after a single exercise session.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24265812/?tool=EBI |
| spellingShingle | Herbert Gustavo Simões Ricardo Yukio Asano Marcelo Magalhães Sales Rodrigo Alberto Vieira Browne Gisela Arsa Daisy Motta-Santos Guilherme Morais Puga Laila Cândida de Jesus Lima Carmen Sílvia Grubert Campbell Octavio Luiz Franco Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition. PLoS ONE |
| title | Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition. |
| title_full | Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition. |
| title_fullStr | Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition. |
| title_full_unstemmed | Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition. |
| title_short | Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition. |
| title_sort | type 2 diabetes elicits lower nitric oxide bradykinin concentration and kallikrein activity together with higher desarg 9 bk and reduced post exercise hypotension compared to non diabetic condition |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24265812/?tool=EBI |
| work_keys_str_mv | AT herbertgustavosimoes type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT ricardoyukioasano type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT marcelomagalhaessales type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT rodrigoalbertovieirabrowne type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT giselaarsa type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT daisymottasantos type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT guilhermemoraispuga type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT lailacandidadejesuslima type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT carmensilviagrubertcampbell type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT octavioluizfranco type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition |