Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways
Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents. Recent advances in DNA sequencing technologies and bioinformatics unveiled nature's great potential for synt...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004219305413 |
| _version_ | 1818498107320565760 |
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| author | Hengqian Ren Chengyou Shi Huimin Zhao |
| author_facet | Hengqian Ren Chengyou Shi Huimin Zhao |
| author_sort | Hengqian Ren |
| collection | DOAJ |
| description | Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents. Recent advances in DNA sequencing technologies and bioinformatics unveiled nature's great potential for synthesizing numerous NPs that may confer unprecedented structural and biological features. However, discovering novel bioactive NPs by genome mining remains a challenge. Moreover, even with interesting bioactivity, the low productivity of many NPs significantly limits their practical applications. Here we discuss the progress in developing bioinformatics tools for efficient discovery of bioactive NPs. In addition, we highlight computational methods for optimizing the productivity of NPs of pharmaceutical importance. : Biological Sciences; Bioengineering; Metabolic Engineering; Bioinformatics Subject Areas: Biological Sciences, Bioengineering, Metabolic Engineering, Bioinformatics |
| first_indexed | 2024-12-10T18:53:50Z |
| format | Article |
| id | doaj.art-ccf0fdafcbf344c796ae876a43450138 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-10T18:53:50Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-ccf0fdafcbf344c796ae876a434501382022-12-22T01:37:14ZengElsevieriScience2589-00422020-01-01231Computational Tools for Discovering and Engineering Natural Product Biosynthetic PathwaysHengqian Ren0Chengyou Shi1Huimin Zhao2Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USADepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USADepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Departments of Chemistry, Biochemistry, and Bioengineering, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Corresponding authorNatural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents. Recent advances in DNA sequencing technologies and bioinformatics unveiled nature's great potential for synthesizing numerous NPs that may confer unprecedented structural and biological features. However, discovering novel bioactive NPs by genome mining remains a challenge. Moreover, even with interesting bioactivity, the low productivity of many NPs significantly limits their practical applications. Here we discuss the progress in developing bioinformatics tools for efficient discovery of bioactive NPs. In addition, we highlight computational methods for optimizing the productivity of NPs of pharmaceutical importance. : Biological Sciences; Bioengineering; Metabolic Engineering; Bioinformatics Subject Areas: Biological Sciences, Bioengineering, Metabolic Engineering, Bioinformaticshttp://www.sciencedirect.com/science/article/pii/S2589004219305413 |
| spellingShingle | Hengqian Ren Chengyou Shi Huimin Zhao Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways iScience |
| title | Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways |
| title_full | Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways |
| title_fullStr | Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways |
| title_full_unstemmed | Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways |
| title_short | Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways |
| title_sort | computational tools for discovering and engineering natural product biosynthetic pathways |
| url | http://www.sciencedirect.com/science/article/pii/S2589004219305413 |
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