Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings
This work was concerned with the fabrication of a porous hydrogel system suitable for medium to heavy-exudating wounds where traditional hydrogels cannot be used. The hydrogels were based on 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPs). In order to produce the porous structure, additional co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/6/459 |
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| author | Thanyaporn Pinthong Maytinee Yooyod Jinjutha Daengmankhong Nantaprapa Tuancharoensri Sararat Mahasaranon Jarupa Viyoch Jirapas Jongjitwimol Sukunya Ross Gareth M. Ross |
| author_facet | Thanyaporn Pinthong Maytinee Yooyod Jinjutha Daengmankhong Nantaprapa Tuancharoensri Sararat Mahasaranon Jarupa Viyoch Jirapas Jongjitwimol Sukunya Ross Gareth M. Ross |
| author_sort | Thanyaporn Pinthong |
| collection | DOAJ |
| description | This work was concerned with the fabrication of a porous hydrogel system suitable for medium to heavy-exudating wounds where traditional hydrogels cannot be used. The hydrogels were based on 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPs). In order to produce the porous structure, additional components were added (acid, blowing agent, foam stabilizer). Manuka honey (MH) was also incorporated at concentrations of 1 and 10% <i>w</i>/<i>w</i>. The hydrogel samples were characterized for morphology via scanning electron microscopy, mechanical rheology, swelling using a gravimetric method, surface absorption, and cell cytotoxicity. The results confirmed the formation of porous hydrogels (PH) with pore sizes ranging from ~50–110 µm. The swelling performance showed that the non-porous hydrogel (NPH) swelled to ~2000%, while PH weight increased ~5000%. Additionally, the use of a surface absorption technique showed that the PH absorbed 10 μL in <3000 ms, and NPH absorbed <1 μL over the same time. Incorporating MH the enhanced gel appearance and mechanical properties, including smaller pores and linear swelling. In summary, the PH produced in this study had excellent swelling performance with rapid absorption of surface liquid. Therefore, these materials have the potential to expand the applicability of hydrogels to a range of wound types, as they can both donate and absorb fluid. |
| first_indexed | 2024-03-11T02:26:45Z |
| format | Article |
| id | doaj.art-ccf1e7789d7045afb9f6b9891d96162f |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T02:26:45Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-ccf1e7789d7045afb9f6b9891d96162f2023-11-18T10:32:14ZengMDPI AGGels2310-28612023-06-019645910.3390/gels9060459Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound DressingsThanyaporn Pinthong0Maytinee Yooyod1Jinjutha Daengmankhong2Nantaprapa Tuancharoensri3Sararat Mahasaranon4Jarupa Viyoch5Jirapas Jongjitwimol6Sukunya Ross7Gareth M. Ross8Biopolymer Group, Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, ThailandBiopolymer Group, Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, ThailandBiopolymer Group, Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, ThailandBiopolymer Group, Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, ThailandBiopolymer Group, Department of Chemistry, Center of Excellence in Biomaterials, Faculty of Science, Naresuan University, Phitsanulok 65000, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, ThailandDepartment of Medical Technology, Faculty of Allied Health Sciences and Center of Excellence in Biomaterials, Faculty of Science, Naresuan University, Phitsanulok 65000, ThailandBiopolymer Group, Department of Chemistry, Center of Excellence in Biomaterials, Faculty of Science, Naresuan University, Phitsanulok 65000, ThailandBiopolymer Group, Department of Chemistry, Center of Excellence in Biomaterials, Faculty of Science, Naresuan University, Phitsanulok 65000, ThailandThis work was concerned with the fabrication of a porous hydrogel system suitable for medium to heavy-exudating wounds where traditional hydrogels cannot be used. The hydrogels were based on 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPs). In order to produce the porous structure, additional components were added (acid, blowing agent, foam stabilizer). Manuka honey (MH) was also incorporated at concentrations of 1 and 10% <i>w</i>/<i>w</i>. The hydrogel samples were characterized for morphology via scanning electron microscopy, mechanical rheology, swelling using a gravimetric method, surface absorption, and cell cytotoxicity. The results confirmed the formation of porous hydrogels (PH) with pore sizes ranging from ~50–110 µm. The swelling performance showed that the non-porous hydrogel (NPH) swelled to ~2000%, while PH weight increased ~5000%. Additionally, the use of a surface absorption technique showed that the PH absorbed 10 μL in <3000 ms, and NPH absorbed <1 μL over the same time. Incorporating MH the enhanced gel appearance and mechanical properties, including smaller pores and linear swelling. In summary, the PH produced in this study had excellent swelling performance with rapid absorption of surface liquid. Therefore, these materials have the potential to expand the applicability of hydrogels to a range of wound types, as they can both donate and absorb fluid.https://www.mdpi.com/2310-2861/9/6/459porous hydrogelswound dressingsManuka honeysurface absorption2-acrylamido-2-methyl-1-propane sulphonic acid |
| spellingShingle | Thanyaporn Pinthong Maytinee Yooyod Jinjutha Daengmankhong Nantaprapa Tuancharoensri Sararat Mahasaranon Jarupa Viyoch Jirapas Jongjitwimol Sukunya Ross Gareth M. Ross Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings Gels porous hydrogels wound dressings Manuka honey surface absorption 2-acrylamido-2-methyl-1-propane sulphonic acid |
| title | Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
| title_full | Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
| title_fullStr | Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
| title_full_unstemmed | Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
| title_short | Development of Natural Active Agent-Containing Porous Hydrogel Sheets with High Water Content for Wound Dressings |
| title_sort | development of natural active agent containing porous hydrogel sheets with high water content for wound dressings |
| topic | porous hydrogels wound dressings Manuka honey surface absorption 2-acrylamido-2-methyl-1-propane sulphonic acid |
| url | https://www.mdpi.com/2310-2861/9/6/459 |
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