Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray)
The objective: evidence-based study of the factors influencing tuberculosis mortality in the Kamchatskiy Kray as a territory withlow population density.Subjects and Methods. A retrospective cohort study of the unfavorable course of tuberculosis in 512 patients with tuberculosis (new cases and relapse...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2022-12-01
|
| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1692 |
| _version_ | 1826563012145709056 |
|---|---|
| author | A. V. Gromov S. A. Sterlikov Yu. V. Mikhaylova |
| author_facet | A. V. Gromov S. A. Sterlikov Yu. V. Mikhaylova |
| author_sort | A. V. Gromov |
| collection | DOAJ |
| description | The objective: evidence-based study of the factors influencing tuberculosis mortality in the Kamchatskiy Kray as a territory withlow population density.Subjects and Methods. A retrospective cohort study of the unfavorable course of tuberculosis in 512 patients with tuberculosis (new cases and relapses) was carried out. A univariate and multivariate analysis of risk factors for a lethal outcome of tuberculosis was performed.Results. In a univariate analysis, the incidence of death from tuberculosis among increased in older patients (p < 0.0001), among the unemployed, pensioners and disabled (p = 0.02), homeless (p = 0.01), persons who failed to undergo fluorography for 2 years or more (p = 0.004), patients with a positive result of sputum smear test at registration (p = 0.003), and those suffering from alcoholism (p = 0.03), and decreased in patients who were actively detected (p < 0.0001 ). There was no influence on the probability of death from tuberculosis in the registration group by such parameters as new cases/relapses (p = 0.2), male/female (p = 0.09), urban/rural area of residence (p = 0.7), belonging to the indigenous population (p = 0.6), resistance to rifampicin (p = 1), cardiovascular diseases (p = 0.5), and smoking (p = 0.3). In multivariate analysis, an independent factor that reduced the risk of death was the active detection of tuberculosis patients (aOR = 0.2, p = 0.02).Conclusion. To reduce the risk of death from tuberculosis in an area with low population density (Kamchatskiy Kray), the priority should be given to improvement of active detection of tuberculosis cases; the proportion of tuberculosis patients detected during preventive screening should be used as an parameter of this improvement. |
| first_indexed | 2024-03-12T04:23:20Z |
| format | Article |
| id | doaj.art-ccf3d444960d4f7baa8e78a1635c947a |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2025-03-14T09:57:11Z |
| publishDate | 2022-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-ccf3d444960d4f7baa8e78a1635c947a2025-03-02T11:22:35ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062022-12-0110011485510.21292/2075-1230-2022-100-11-48-551687Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray)A. V. Gromov0S. A. Sterlikov1Yu. V. Mikhaylova2Kamchatka Regional Clinical TB DispensaryRussian Research Institute of Health; National Medical Research Center of Phthisiopulmonology and Infectious DiseasesRussian Research Institute of HealthThe objective: evidence-based study of the factors influencing tuberculosis mortality in the Kamchatskiy Kray as a territory withlow population density.Subjects and Methods. A retrospective cohort study of the unfavorable course of tuberculosis in 512 patients with tuberculosis (new cases and relapses) was carried out. A univariate and multivariate analysis of risk factors for a lethal outcome of tuberculosis was performed.Results. In a univariate analysis, the incidence of death from tuberculosis among increased in older patients (p < 0.0001), among the unemployed, pensioners and disabled (p = 0.02), homeless (p = 0.01), persons who failed to undergo fluorography for 2 years or more (p = 0.004), patients with a positive result of sputum smear test at registration (p = 0.003), and those suffering from alcoholism (p = 0.03), and decreased in patients who were actively detected (p < 0.0001 ). There was no influence on the probability of death from tuberculosis in the registration group by such parameters as new cases/relapses (p = 0.2), male/female (p = 0.09), urban/rural area of residence (p = 0.7), belonging to the indigenous population (p = 0.6), resistance to rifampicin (p = 1), cardiovascular diseases (p = 0.5), and smoking (p = 0.3). In multivariate analysis, an independent factor that reduced the risk of death was the active detection of tuberculosis patients (aOR = 0.2, p = 0.02).Conclusion. To reduce the risk of death from tuberculosis in an area with low population density (Kamchatskiy Kray), the priority should be given to improvement of active detection of tuberculosis cases; the proportion of tuberculosis patients detected during preventive screening should be used as an parameter of this improvement.https://www.tibl-journal.com/jour/article/view/1692tuberculosismortalitypredictorsrisk of death |
| spellingShingle | A. V. Gromov S. A. Sterlikov Yu. V. Mikhaylova Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray) Туберкулез и болезни лёгких tuberculosis mortality predictors risk of death |
| title | Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray) |
| title_full | Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray) |
| title_fullStr | Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray) |
| title_full_unstemmed | Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray) |
| title_short | Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray) |
| title_sort | risk factors of lethal outcomes of tuberculosis in a region with low population density kamchatskiy kray |
| topic | tuberculosis mortality predictors risk of death |
| url | https://www.tibl-journal.com/jour/article/view/1692 |
| work_keys_str_mv | AT avgromov riskfactorsoflethaloutcomesoftuberculosisinaregionwithlowpopulationdensitykamchatskiykray AT sasterlikov riskfactorsoflethaloutcomesoftuberculosisinaregionwithlowpopulationdensitykamchatskiykray AT yuvmikhaylova riskfactorsoflethaloutcomesoftuberculosisinaregionwithlowpopulationdensitykamchatskiykray |