An oral live attenuated vaccine strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) infection has become a pandemic called COVID-19. The virus binds to angiotensin converting enzyme 2 (ACE2) and TMPRSS2 which are abundantly expressed on various human cells including lung epithelial cells and intestinal cells and...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2020-05-01
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| Series: | Research Ideas and Outcomes |
| Subjects: | |
| Online Access: | https://riojournal.com/article/53767/download/pdf/ |
| _version_ | 1818419824778280960 |
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| author | Madhusudana Girija Sanal Ravi Chandra Duby |
| author_facet | Madhusudana Girija Sanal Ravi Chandra Duby |
| author_sort | Madhusudana Girija Sanal |
| collection | DOAJ |
| description | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) infection has become a pandemic called COVID-19. The virus binds to angiotensin converting enzyme 2 (ACE2) and TMPRSS2 which are abundantly expressed on various human cells including lung epithelial cells and intestinal cells and the virus can infect these cells. Currently no specific treatments or vaccines are available for this disease. A per oral live attenuated vaccine can be a good strategy in SARS-CoV-2 infection because the attenuated virus initially infects the gut, stimulates the mucosa associated immune system sparing the respiratory system during the initial immune response. The live virus can also spread in the community boosting herd immunity. |
| first_indexed | 2024-12-14T12:44:43Z |
| format | Article |
| id | doaj.art-ccf446a5f8564717bfeb1c8e90df8199 |
| institution | Directory Open Access Journal |
| issn | 2367-7163 |
| language | English |
| last_indexed | 2024-12-14T12:44:43Z |
| publishDate | 2020-05-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Research Ideas and Outcomes |
| spelling | doaj.art-ccf446a5f8564717bfeb1c8e90df81992022-12-21T23:00:49ZengPensoft PublishersResearch Ideas and Outcomes2367-71632020-05-0161810.3897/rio.6.e5376753767An oral live attenuated vaccine strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV)Madhusudana Girija Sanal0Ravi Chandra Duby1Institute of Liver and Biliary SciencesSouth Asian UniversitySevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) infection has become a pandemic called COVID-19. The virus binds to angiotensin converting enzyme 2 (ACE2) and TMPRSS2 which are abundantly expressed on various human cells including lung epithelial cells and intestinal cells and the virus can infect these cells. Currently no specific treatments or vaccines are available for this disease. A per oral live attenuated vaccine can be a good strategy in SARS-CoV-2 infection because the attenuated virus initially infects the gut, stimulates the mucosa associated immune system sparing the respiratory system during the initial immune response. The live virus can also spread in the community boosting herd immunity.https://riojournal.com/article/53767/download/pdf/Oral Live Attenuated VaccineSevere Acute Respira |
| spellingShingle | Madhusudana Girija Sanal Ravi Chandra Duby An oral live attenuated vaccine strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) Research Ideas and Outcomes Oral Live Attenuated Vaccine Severe Acute Respira |
| title | An oral live attenuated vaccine strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) |
| title_full | An oral live attenuated vaccine strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) |
| title_fullStr | An oral live attenuated vaccine strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) |
| title_full_unstemmed | An oral live attenuated vaccine strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) |
| title_short | An oral live attenuated vaccine strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/2019-nCoV) |
| title_sort | oral live attenuated vaccine strategy against severe acute respiratory syndrome coronavirus 2 sars cov 2 2019 ncov |
| topic | Oral Live Attenuated Vaccine Severe Acute Respira |
| url | https://riojournal.com/article/53767/download/pdf/ |
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