S1P/S1PR signaling pathway advancements in autoimmune diseases
Sphingosine-1-phosphate (S1P) is a versatile sphingolipid that is generated through the phosphorylation of sphingosine by sphingosine kinase (SPHK). S1P exerts its functional effects by binding to the G protein-coupled S1P receptor (S1PR). This lipid mediator plays a pivotal role in various cellular...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2023-11-01
|
| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/9082 |
| _version_ | 1827317538359345152 |
|---|---|
| author | Jianbin Li Yiping Huang Yueqin Zhang Pengcheng Liu Mengxia Liu Min Zhang Rui Wu |
| author_facet | Jianbin Li Yiping Huang Yueqin Zhang Pengcheng Liu Mengxia Liu Min Zhang Rui Wu |
| author_sort | Jianbin Li |
| collection | DOAJ |
| description | Sphingosine-1-phosphate (S1P) is a versatile sphingolipid that is generated through the phosphorylation of sphingosine by sphingosine kinase (SPHK). S1P exerts its functional effects by binding to the G protein-coupled S1P receptor (S1PR). This lipid mediator plays a pivotal role in various cellular activities. The S1P/S1PR signaling pathway is implicated in the pathogenesis of immune-mediated diseases, significantly contributing to the functioning of the immune system. It plays a crucial role in diverse physiological and pathophysiological processes, including cell survival, proliferation, migration, immune cell recruitment, synthesis of inflammatory mediators, and the formation of lymphatic and blood vessels. However, the full extent of the involvement of this signaling pathway in the development of autoimmune diseases remains to be fully elucidated. Therefore, this study aims to comprehensively review recent research on the S1P/S1PR axis in diseases related to autoimmunity.
|
| first_indexed | 2024-04-24T23:40:32Z |
| format | Article |
| id | doaj.art-ccf499c1d4034ac38693128ca2316db2 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:40:32Z |
| publishDate | 2023-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-ccf499c1d4034ac38693128ca2316db22024-03-15T13:22:25ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2023-11-0123610.17305/bb.2023.9082S1P/S1PR signaling pathway advancements in autoimmune diseasesJianbin Li0https://orcid.org/0000-0001-9629-8558Yiping Huang1https://orcid.org/0000-0002-6072-8533Yueqin Zhang2Pengcheng Liu3https://orcid.org/0000-0002-9144-1623Mengxia Liu4Min Zhang5Rui Wu6Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaSphingosine-1-phosphate (S1P) is a versatile sphingolipid that is generated through the phosphorylation of sphingosine by sphingosine kinase (SPHK). S1P exerts its functional effects by binding to the G protein-coupled S1P receptor (S1PR). This lipid mediator plays a pivotal role in various cellular activities. The S1P/S1PR signaling pathway is implicated in the pathogenesis of immune-mediated diseases, significantly contributing to the functioning of the immune system. It plays a crucial role in diverse physiological and pathophysiological processes, including cell survival, proliferation, migration, immune cell recruitment, synthesis of inflammatory mediators, and the formation of lymphatic and blood vessels. However, the full extent of the involvement of this signaling pathway in the development of autoimmune diseases remains to be fully elucidated. Therefore, this study aims to comprehensively review recent research on the S1P/S1PR axis in diseases related to autoimmunity. https://www.bjbms.org/ojs/index.php/bjbms/article/view/9082Sphingosine-1-phosphate (S1P)sphingosine-1-phosphate receptor (S1PR)S1P/S1PR signaling pathwayautoimmune diseasesresearch progress |
| spellingShingle | Jianbin Li Yiping Huang Yueqin Zhang Pengcheng Liu Mengxia Liu Min Zhang Rui Wu S1P/S1PR signaling pathway advancements in autoimmune diseases Biomolecules & Biomedicine Sphingosine-1-phosphate (S1P) sphingosine-1-phosphate receptor (S1PR) S1P/S1PR signaling pathway autoimmune diseases research progress |
| title | S1P/S1PR signaling pathway advancements in autoimmune diseases |
| title_full | S1P/S1PR signaling pathway advancements in autoimmune diseases |
| title_fullStr | S1P/S1PR signaling pathway advancements in autoimmune diseases |
| title_full_unstemmed | S1P/S1PR signaling pathway advancements in autoimmune diseases |
| title_short | S1P/S1PR signaling pathway advancements in autoimmune diseases |
| title_sort | s1p s1pr signaling pathway advancements in autoimmune diseases |
| topic | Sphingosine-1-phosphate (S1P) sphingosine-1-phosphate receptor (S1PR) S1P/S1PR signaling pathway autoimmune diseases research progress |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/9082 |
| work_keys_str_mv | AT jianbinli s1ps1prsignalingpathwayadvancementsinautoimmunediseases AT yipinghuang s1ps1prsignalingpathwayadvancementsinautoimmunediseases AT yueqinzhang s1ps1prsignalingpathwayadvancementsinautoimmunediseases AT pengchengliu s1ps1prsignalingpathwayadvancementsinautoimmunediseases AT mengxialiu s1ps1prsignalingpathwayadvancementsinautoimmunediseases AT minzhang s1ps1prsignalingpathwayadvancementsinautoimmunediseases AT ruiwu s1ps1prsignalingpathwayadvancementsinautoimmunediseases |