Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells
Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterize...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Diabetes Association
2013-04-01
|
| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-37-91.pdf |
| _version_ | 1828765530065993728 |
|---|---|
| author | Ji Woong Han Min Young Sin Young-sup Yoon |
| author_facet | Ji Woong Han Min Young Sin Young-sup Yoon |
| author_sort | Ji Woong Han |
| collection | DOAJ |
| description | Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem or progenitor cells contain various angiogenic and neurotrophic factors, these cells have been attempted for treating experimental DN, and turned out to be effective for reversing various manifestations of experimental DN. These evidences suggest that cell therapy, affecting both vascular and neural components, can represent a novel therapeutic option for treatment of clinical DN. |
| first_indexed | 2024-12-11T06:50:09Z |
| format | Article |
| id | doaj.art-ccf505e881894cdea86b1d5350025eb0 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-11T06:50:09Z |
| publishDate | 2013-04-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-ccf505e881894cdea86b1d5350025eb02022-12-22T01:16:57ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872013-04-013729110510.4093/dmj.2013.37.2.912372Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor CellsJi Woong HanMin Young SinYoung-sup YoonDiabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem or progenitor cells contain various angiogenic and neurotrophic factors, these cells have been attempted for treating experimental DN, and turned out to be effective for reversing various manifestations of experimental DN. These evidences suggest that cell therapy, affecting both vascular and neural components, can represent a novel therapeutic option for treatment of clinical DN.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-37-91.pdfDiabetic neuropathiesStem cellsTissue therapy |
| spellingShingle | Ji Woong Han Min Young Sin Young-sup Yoon Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells Diabetes & Metabolism Journal Diabetic neuropathies Stem cells Tissue therapy |
| title | Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| title_full | Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| title_fullStr | Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| title_full_unstemmed | Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| title_short | Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells |
| title_sort | cell therapy for diabetic neuropathy using adult stem or progenitor cells |
| topic | Diabetic neuropathies Stem cells Tissue therapy |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-37-91.pdf |
| work_keys_str_mv | AT jiwoonghan celltherapyfordiabeticneuropathyusingadultstemorprogenitorcells AT minyoungsin celltherapyfordiabeticneuropathyusingadultstemorprogenitorcells AT youngsupyoon celltherapyfordiabeticneuropathyusingadultstemorprogenitorcells |