Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control Study
Evidence of the association between maternal sulfur dioxide (SO2) exposure and the risk of omphalocele is limited and equivocal. We aimed to assess the aforementioned topic during the first trimester of pregnancy. A population-based case-control study was carried out in infants consisting of 292 cas...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.821905/full |
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| author | Li-Li Li Yan-Hong Huang Jing Li Shu Liu Yan-Ling Chen Cheng-Zhi Jiang Zong-Jiao Chen Yan-Yan Zhuang |
| author_facet | Li-Li Li Yan-Hong Huang Jing Li Shu Liu Yan-Ling Chen Cheng-Zhi Jiang Zong-Jiao Chen Yan-Yan Zhuang |
| author_sort | Li-Li Li |
| collection | DOAJ |
| description | Evidence of the association between maternal sulfur dioxide (SO2) exposure and the risk of omphalocele is limited and equivocal. We aimed to assess the aforementioned topic during the first trimester of pregnancy. A population-based case-control study was carried out in infants consisting of 292 cases of omphalocele and 7,950 healthy infant controls. Exposure to SO2, particulate matter with aerodynamic diameters ≤ 10 μm, and nitrogen dioxide was assessed by averaging the concentration from all stations in the mother's residential city. SO2 exposure was categorized into three groups, with the lowest tertile defined as the reference category. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression models. Higher SO2 exposure during the first trimester was significantly associated with omphalocele risk [per standard deviation (42 ug/m3) increment: OR = 1.39, 95% CI = 1.22–1.65]. When focusing on shorter exposure windows, similar positive associations were observed for SO2 exposure in the first and third months of pregnancy. In addition, compared with the lowest tertile, high SO2 exposure in the second month of pregnancy increased the risk of omphalocele (OR = 2.80, 95% CI = 1.61–4.97). Maternal exposure to SO2 during the first trimester may increase the risk of omphalocele in offspring. |
| first_indexed | 2024-04-13T08:32:42Z |
| format | Article |
| id | doaj.art-ccf58f49507b4b30906f381dddc8b418 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-13T08:32:42Z |
| publishDate | 2022-05-01 |
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| series | Frontiers in Public Health |
| spelling | doaj.art-ccf58f49507b4b30906f381dddc8b4182022-12-22T02:54:12ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-05-011010.3389/fpubh.2022.821905821905Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control StudyLi-Li Li0Yan-Hong Huang1Jing Li2Shu Liu3Yan-Ling Chen4Cheng-Zhi Jiang5Zong-Jiao Chen6Yan-Yan Zhuang7Department of Children's Health Prevention, Shenyang Maternity and Child Health Hospital, Shenyang, ChinaDepartment of Ophthalmology, Shenyang Women's and Children's Hospital, Shenyang, ChinaDepartment of Science and Education, Shenyang Maternity and Child Health Hospital, Shenyang, ChinaDepartment of Atmospheric Environment Monitoring, Liaoning Eco-Environmental Monitoring Center, Shenyang, ChinaOffice of Institution, Liaoning Women and Children's Health Hospital, Shenyang, ChinaSchool of Environmental and Chemical Engineering, Shenyang Ligong University, Shenyang, ChinaDepartment of Atmospheric Environment Monitoring, Liaoning Eco-Environmental Monitoring Center, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, ChinaEvidence of the association between maternal sulfur dioxide (SO2) exposure and the risk of omphalocele is limited and equivocal. We aimed to assess the aforementioned topic during the first trimester of pregnancy. A population-based case-control study was carried out in infants consisting of 292 cases of omphalocele and 7,950 healthy infant controls. Exposure to SO2, particulate matter with aerodynamic diameters ≤ 10 μm, and nitrogen dioxide was assessed by averaging the concentration from all stations in the mother's residential city. SO2 exposure was categorized into three groups, with the lowest tertile defined as the reference category. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression models. Higher SO2 exposure during the first trimester was significantly associated with omphalocele risk [per standard deviation (42 ug/m3) increment: OR = 1.39, 95% CI = 1.22–1.65]. When focusing on shorter exposure windows, similar positive associations were observed for SO2 exposure in the first and third months of pregnancy. In addition, compared with the lowest tertile, high SO2 exposure in the second month of pregnancy increased the risk of omphalocele (OR = 2.80, 95% CI = 1.61–4.97). Maternal exposure to SO2 during the first trimester may increase the risk of omphalocele in offspring.https://www.frontiersin.org/articles/10.3389/fpubh.2022.821905/fullair pollutioncase-control studyomphalocelerisksulfur dioxide |
| spellingShingle | Li-Li Li Yan-Hong Huang Jing Li Shu Liu Yan-Ling Chen Cheng-Zhi Jiang Zong-Jiao Chen Yan-Yan Zhuang Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control Study Frontiers in Public Health air pollution case-control study omphalocele risk sulfur dioxide |
| title | Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control Study |
| title_full | Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control Study |
| title_fullStr | Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control Study |
| title_full_unstemmed | Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control Study |
| title_short | Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control Study |
| title_sort | maternal exposure to sulfur dioxide and risk of omphalocele in liaoning province china a population based case control study |
| topic | air pollution case-control study omphalocele risk sulfur dioxide |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.821905/full |
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