Exosomes: Insights and therapeutic applications in cancer
Cancer refers to the division of abnormal cells at an uncontrollable rate that possesses the ability to infiltrate and destroy normal tissues. It frequently spreads to normal tissues throughout the body, a condition known as metastasis, which is a significant concern. It is the second leading cause...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523322000985 |
| _version_ | 1818208576282296320 |
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| author | Anita Raj Panigrahi Lankalapalli Srinivas Jagadeesh Panda |
| author_facet | Anita Raj Panigrahi Lankalapalli Srinivas Jagadeesh Panda |
| author_sort | Anita Raj Panigrahi |
| collection | DOAJ |
| description | Cancer refers to the division of abnormal cells at an uncontrollable rate that possesses the ability to infiltrate and destroy normal tissues. It frequently spreads to normal tissues throughout the body, a condition known as metastasis, which is a significant concern. It is the second leading cause of mortality globally and treatment therapy can assist in improving survival rates. Exosomes are the extracellular vesicles secreted by several cells that act as messengers between cells. When engineered, exosomes act as promising drug delivery vehicles that help achieve targeted action at the tumour site and reduce the limitations of conventional treatments such as castration, chemotherapy, radiation, etc. The present review provides an overview of exosomes, the biogenesis, sources, isolation methods and characterization. The current status and applications of chemotherapeutic agents loaded, engineered exosomes in cancer treatment were convoluted. |
| first_indexed | 2024-12-12T04:47:01Z |
| format | Article |
| id | doaj.art-ccf5ba8c0abf48e699c8301631997f7b |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-12T04:47:01Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-ccf5ba8c0abf48e699c8301631997f7b2022-12-22T00:37:35ZengElsevierTranslational Oncology1936-52332022-07-0121101439Exosomes: Insights and therapeutic applications in cancerAnita Raj Panigrahi0Lankalapalli Srinivas1Jagadeesh Panda2GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, 530045, IndiaGITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, 530045, India; Corresponding author.Raghu College of Pharmacy, Dakamarri, Visakhapatnam - 531162, IndiaCancer refers to the division of abnormal cells at an uncontrollable rate that possesses the ability to infiltrate and destroy normal tissues. It frequently spreads to normal tissues throughout the body, a condition known as metastasis, which is a significant concern. It is the second leading cause of mortality globally and treatment therapy can assist in improving survival rates. Exosomes are the extracellular vesicles secreted by several cells that act as messengers between cells. When engineered, exosomes act as promising drug delivery vehicles that help achieve targeted action at the tumour site and reduce the limitations of conventional treatments such as castration, chemotherapy, radiation, etc. The present review provides an overview of exosomes, the biogenesis, sources, isolation methods and characterization. The current status and applications of chemotherapeutic agents loaded, engineered exosomes in cancer treatment were convoluted.http://www.sciencedirect.com/science/article/pii/S1936523322000985ExosomesDrug deliveryCancer chemotherapyTargeted drug deliveryClinical trials |
| spellingShingle | Anita Raj Panigrahi Lankalapalli Srinivas Jagadeesh Panda Exosomes: Insights and therapeutic applications in cancer Translational Oncology Exosomes Drug delivery Cancer chemotherapy Targeted drug delivery Clinical trials |
| title | Exosomes: Insights and therapeutic applications in cancer |
| title_full | Exosomes: Insights and therapeutic applications in cancer |
| title_fullStr | Exosomes: Insights and therapeutic applications in cancer |
| title_full_unstemmed | Exosomes: Insights and therapeutic applications in cancer |
| title_short | Exosomes: Insights and therapeutic applications in cancer |
| title_sort | exosomes insights and therapeutic applications in cancer |
| topic | Exosomes Drug delivery Cancer chemotherapy Targeted drug delivery Clinical trials |
| url | http://www.sciencedirect.com/science/article/pii/S1936523322000985 |
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