Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal Study
Background: To characterize the longitudinal changes of macular vessel density in young adults and its associated factors.Methods: The right eyes of 309 participants (75 high myopic, 194 mild-to-moderate myopic, and 40 healthy) were followed up for 21 months. OCTA images were acquired at two visits...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.648644/full |
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| author | Ya Shi Ya Shi Luyao Ye Luyao Ye Qiuying Chen Qiuying Chen Guangyi Hu Guangyi Hu Yao Yin Ying Fan Jianfeng Zhu Jiangnan He Zhi Zheng Haidong Zou Haidong Zou Xun Xu Xun Xu |
| author_facet | Ya Shi Ya Shi Luyao Ye Luyao Ye Qiuying Chen Qiuying Chen Guangyi Hu Guangyi Hu Yao Yin Ying Fan Jianfeng Zhu Jiangnan He Zhi Zheng Haidong Zou Haidong Zou Xun Xu Xun Xu |
| author_sort | Ya Shi |
| collection | DOAJ |
| description | Background: To characterize the longitudinal changes of macular vessel density in young adults and its associated factors.Methods: The right eyes of 309 participants (75 high myopic, 194 mild-to-moderate myopic, and 40 healthy) were followed up for 21 months. OCTA images were acquired at two visits using follow-up scans. Macular vessel density was calculated globally and in the nine early treatment diabetic retinopathy study (ETDRS) subfields of the macula superficial layer.Results: The macular vessel density significantly decreased in young myopes after a 21-month follow up (p < 0.05), with variations among sectors. Compared with healthy eyes, HM group exhibited a faster reduction in global macular vessel density (p = 0.0307) as well as in sectors of inner-inferior (II), inner-temporal (IT), and outer-temporal (OT) (all p < 0.05). Multivariate regression analysis showed that longer baseline axial length (AL) was significantly associated with larger reduction of macular vessel density in the inner-inferior, inner-temporal and outer-temporal sectors (all p < 0.05).Conclusions: Compared with emmetropes, high myopes presented greater loss of macular vessel density over time in global and in the inner-inferior, inner-temporal and outer-temporal sectors. A longer baseline AL was associated with larger changes of macular vessel density in the inner-inferior, inner-temporal and outer-temporal sectors. |
| first_indexed | 2024-12-15T00:21:23Z |
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| id | doaj.art-ccf801793cc449459fed8164eb9b4e54 |
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| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-15T00:21:23Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-ccf801793cc449459fed8164eb9b4e542022-12-21T22:42:18ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-06-01810.3389/fmed.2021.648644648644Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal StudyYa Shi0Ya Shi1Luyao Ye2Luyao Ye3Qiuying Chen4Qiuying Chen5Guangyi Hu6Guangyi Hu7Yao Yin8Ying Fan9Jianfeng Zhu10Jiangnan He11Zhi Zheng12Haidong Zou13Haidong Zou14Xun Xu15Xun Xu16Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, ChinaDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, ChinaDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, ChinaBackground: To characterize the longitudinal changes of macular vessel density in young adults and its associated factors.Methods: The right eyes of 309 participants (75 high myopic, 194 mild-to-moderate myopic, and 40 healthy) were followed up for 21 months. OCTA images were acquired at two visits using follow-up scans. Macular vessel density was calculated globally and in the nine early treatment diabetic retinopathy study (ETDRS) subfields of the macula superficial layer.Results: The macular vessel density significantly decreased in young myopes after a 21-month follow up (p < 0.05), with variations among sectors. Compared with healthy eyes, HM group exhibited a faster reduction in global macular vessel density (p = 0.0307) as well as in sectors of inner-inferior (II), inner-temporal (IT), and outer-temporal (OT) (all p < 0.05). Multivariate regression analysis showed that longer baseline axial length (AL) was significantly associated with larger reduction of macular vessel density in the inner-inferior, inner-temporal and outer-temporal sectors (all p < 0.05).Conclusions: Compared with emmetropes, high myopes presented greater loss of macular vessel density over time in global and in the inner-inferior, inner-temporal and outer-temporal sectors. A longer baseline AL was associated with larger changes of macular vessel density in the inner-inferior, inner-temporal and outer-temporal sectors.https://www.frontiersin.org/articles/10.3389/fmed.2021.648644/fullmacular vessel densityhigh myopiaoptical coherence tomography angiographyretinal thicknesslongitudinal study |
| spellingShingle | Ya Shi Ya Shi Luyao Ye Luyao Ye Qiuying Chen Qiuying Chen Guangyi Hu Guangyi Hu Yao Yin Ying Fan Jianfeng Zhu Jiangnan He Zhi Zheng Haidong Zou Haidong Zou Xun Xu Xun Xu Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal Study Frontiers in Medicine macular vessel density high myopia optical coherence tomography angiography retinal thickness longitudinal study |
| title | Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal Study |
| title_full | Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal Study |
| title_fullStr | Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal Study |
| title_full_unstemmed | Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal Study |
| title_short | Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal Study |
| title_sort | macular vessel density changes in young adults with high myopia a longitudinal study |
| topic | macular vessel density high myopia optical coherence tomography angiography retinal thickness longitudinal study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.648644/full |
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