Synthesis of the calcilytic ligand NPS 2143

Synthesis of the calcilytic ligand NPS 2143

(R)-3 (NPS 2143) is a negative allosteric modulator of the human calcium-sensing receptor (CaSR) and as such represents an important pharmacological tool compound for studying the CaSR. Herein, we disclose for the first time a complete experimental description, detailed characterisation and assessme...

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Bibliographic Details
Main Authors:	Henrik Johansson, Thomas Cailly, Alex Rojas Bie Thomsen, Hans Bräuner-Osborne, Daniel Sejer Pedersen
Format:	Article
Language:	English
Published:	Beilstein-Institut 2013-07-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	epoxides GPCR NPS 2143 nucleophilic aromatic substitution pyrylium chemistry
Online Access:	https://doi.org/10.3762/bjoc.9.154

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