Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus
We investigated serum concentration of C-reactive protein (CRP) and measures of adiposity in 30 patients with type 2 diabetes mellitus (15 male, 15 female) and 30 age and sex-matched apparently healthy subjects. CRP concentration was determined by laser nephelometry (BN II Analyzer) and CardioPhas...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2007-11-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3021 |
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| author | Asija Začiragić Jasminko Huskić Almira Hadžović-Džuvo Amina Valjevac Nesina Avdagić Nedžad Mulabegović |
| author_facet | Asija Začiragić Jasminko Huskić Almira Hadžović-Džuvo Amina Valjevac Nesina Avdagić Nedžad Mulabegović |
| author_sort | Asija Začiragić |
| collection | DOAJ |
| description | We investigated serum concentration of C-reactive protein (CRP) and measures of adiposity in 30 patients with type 2 diabetes mellitus (15 male, 15 female) and 30 age and sex-matched apparently healthy subjects.
CRP concentration was determined by laser nephelometry (BN II Analyzer) and CardioPhase high-sensitivity CRP (DADE BEHRING) was used as reagent which consists of polystyrene particles coated with mouse monoclonal antibodies to CRP.
Results have shown that serum CRP concentration in patients with type 2 diabetes mellitus was statistically significantly higher compared to control group of healthy subjects (p<0,05). Body mass index (BMI) correlated significantly with serum concentration of CRP in patients with type 2 diabetes mellitus (r=0,614; p<0,001). Statistically significant positive correlation was also found between waist to hip ratio and serum CRP concentration in patients with type 2 diabetes mellitus (r=0,426; p<0,05).
Elevated serum CRP concentration in patients with type 2 diabetes mellitus is probably caused by the presence of chronic low-grade inflammation in these patients. It is possible that determined increase of CRP concentration reflects activation of innate immune system components in patients with type 2 diabetes mellitus. Implications of established association between measures of adiposity and serum CRP level in type 2 diabetes mellitus remain unclear.
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| first_indexed | 2024-04-24T23:31:50Z |
| format | Article |
| id | doaj.art-ccfb0c08cdc446c6ad8994d3fd9a1bfb |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:31:50Z |
| publishDate | 2007-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-ccfb0c08cdc446c6ad8994d3fd9a1bfb2024-03-15T14:38:18ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2007-11-017410.17305/bjbms.2007.3021606Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes MellitusAsija Začiragić0Jasminko Huskić1Almira Hadžović-Džuvo2Amina Valjevac3Nesina Avdagić4Nedžad Mulabegović5Institute of Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute of Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute of Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute of Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute of Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of SarajevoWe investigated serum concentration of C-reactive protein (CRP) and measures of adiposity in 30 patients with type 2 diabetes mellitus (15 male, 15 female) and 30 age and sex-matched apparently healthy subjects. CRP concentration was determined by laser nephelometry (BN II Analyzer) and CardioPhase high-sensitivity CRP (DADE BEHRING) was used as reagent which consists of polystyrene particles coated with mouse monoclonal antibodies to CRP. Results have shown that serum CRP concentration in patients with type 2 diabetes mellitus was statistically significantly higher compared to control group of healthy subjects (p<0,05). Body mass index (BMI) correlated significantly with serum concentration of CRP in patients with type 2 diabetes mellitus (r=0,614; p<0,001). Statistically significant positive correlation was also found between waist to hip ratio and serum CRP concentration in patients with type 2 diabetes mellitus (r=0,426; p<0,05). Elevated serum CRP concentration in patients with type 2 diabetes mellitus is probably caused by the presence of chronic low-grade inflammation in these patients. It is possible that determined increase of CRP concentration reflects activation of innate immune system components in patients with type 2 diabetes mellitus. Implications of established association between measures of adiposity and serum CRP level in type 2 diabetes mellitus remain unclear. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3021serum C-reactive proteinadipositytype 2 diabetes mellitus |
| spellingShingle | Asija Začiragić Jasminko Huskić Almira Hadžović-Džuvo Amina Valjevac Nesina Avdagić Nedžad Mulabegović Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus Biomolecules & Biomedicine serum C-reactive protein adiposity type 2 diabetes mellitus |
| title | Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus |
| title_full | Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus |
| title_fullStr | Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus |
| title_full_unstemmed | Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus |
| title_short | Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus |
| title_sort | serum c reactive protein concentration and measures of adiposity in patients with type 2 diabetes mellitus |
| topic | serum C-reactive protein adiposity type 2 diabetes mellitus |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3021 |
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