Building Team Medicine in the Management of CNS Metastases
CNS metastases are often terminal for cancer patients and occur at an approximately 10-fold higher rate than primary CNS tumors. The incidence of these tumors is approximately 70,000–400,000 cases annually in the US. Advances that have occurred over the past two decades have led to more personalized...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/12/3901 |
| _version_ | 1797594168328978432 |
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| author | Archit B. Baskaran Robin A. Buerki Osaama H. Khan Vinai Gondi Roger Stupp Rimas V. Lukas Victoria M. Villaflor |
| author_facet | Archit B. Baskaran Robin A. Buerki Osaama H. Khan Vinai Gondi Roger Stupp Rimas V. Lukas Victoria M. Villaflor |
| author_sort | Archit B. Baskaran |
| collection | DOAJ |
| description | CNS metastases are often terminal for cancer patients and occur at an approximately 10-fold higher rate than primary CNS tumors. The incidence of these tumors is approximately 70,000–400,000 cases annually in the US. Advances that have occurred over the past two decades have led to more personalized treatment approaches. Newer surgical and radiation techniques, as well as targeted and immune therapies, have enanled patient to live longer, thus increasing the risk for the development of CNS, brain, and leptomeningeal metastases (BM and LM). Patients who develop CNS metastases have often been heavily treated, and options for future treatment could best be addressed by multidisciplinary teams. Studies have indicated that patients with brain metastases have improved survival outcomes when cared for in high-volume academic institutions using multidisciplinary teams. This manuscript discusses a multidisciplinary approach for both parenchymal brain metastases as well as leptomeningeal metastases implemented in three academic institutions. Additionally, with the increasing development of healthcare systems, we discuss optimizing the management of CNS metastases across healthcare systems and integrating basic and translational science into our clinical care to further improve outcomes. This paper summarizes the existing therapeutic approaches to the treatment of BM and LM and discusses novel and emerging approaches to optimizing access to neuro-oncologic care while simultaneously integrating multidisciplinary teams in the care of patients with BM and LM. |
| first_indexed | 2024-03-11T02:19:47Z |
| format | Article |
| id | doaj.art-ccfbd8ee29c949d2be124bfaed65aa7d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T02:19:47Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ccfbd8ee29c949d2be124bfaed65aa7d2023-11-18T10:58:14ZengMDPI AGJournal of Clinical Medicine2077-03832023-06-011212390110.3390/jcm12123901Building Team Medicine in the Management of CNS MetastasesArchit B. Baskaran0Robin A. Buerki1Osaama H. Khan2Vinai Gondi3Roger Stupp4Rimas V. Lukas5Victoria M. Villaflor6Department of Neurology, The University of Chicago, Chicago, IL 60637, USAHealth System Clinician of Neurology (Neuro-Oncology), Northwestern Medicine Regional Medical Group, Warrenville, IL 60555, USASurgical Neuro-Oncology, Northwestern Medicine Central DuPage Hospital, Winfield, IL 60190, USADepartment of Radiation Oncology, Nothwestern Medicine West Region, Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Warrenville, IL 60555, USANeuro-Oncology Division, Neurological Surgery, Medicine (Hematology and Oncology), Neurology, Department of Neurology, Lou & Jean Malnati Brain Tumor Institute Northwestern University, Chicago, IL 60611, USANeuro-Oncology Division, Department of Neurology, Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL 60611, USADepartment of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA 91010, USACNS metastases are often terminal for cancer patients and occur at an approximately 10-fold higher rate than primary CNS tumors. The incidence of these tumors is approximately 70,000–400,000 cases annually in the US. Advances that have occurred over the past two decades have led to more personalized treatment approaches. Newer surgical and radiation techniques, as well as targeted and immune therapies, have enanled patient to live longer, thus increasing the risk for the development of CNS, brain, and leptomeningeal metastases (BM and LM). Patients who develop CNS metastases have often been heavily treated, and options for future treatment could best be addressed by multidisciplinary teams. Studies have indicated that patients with brain metastases have improved survival outcomes when cared for in high-volume academic institutions using multidisciplinary teams. This manuscript discusses a multidisciplinary approach for both parenchymal brain metastases as well as leptomeningeal metastases implemented in three academic institutions. Additionally, with the increasing development of healthcare systems, we discuss optimizing the management of CNS metastases across healthcare systems and integrating basic and translational science into our clinical care to further improve outcomes. This paper summarizes the existing therapeutic approaches to the treatment of BM and LM and discusses novel and emerging approaches to optimizing access to neuro-oncologic care while simultaneously integrating multidisciplinary teams in the care of patients with BM and LM.https://www.mdpi.com/2077-0383/12/12/3901brain metastasesdelivery of health careleptomeningeal metastasestumor board |
| spellingShingle | Archit B. Baskaran Robin A. Buerki Osaama H. Khan Vinai Gondi Roger Stupp Rimas V. Lukas Victoria M. Villaflor Building Team Medicine in the Management of CNS Metastases Journal of Clinical Medicine brain metastases delivery of health care leptomeningeal metastases tumor board |
| title | Building Team Medicine in the Management of CNS Metastases |
| title_full | Building Team Medicine in the Management of CNS Metastases |
| title_fullStr | Building Team Medicine in the Management of CNS Metastases |
| title_full_unstemmed | Building Team Medicine in the Management of CNS Metastases |
| title_short | Building Team Medicine in the Management of CNS Metastases |
| title_sort | building team medicine in the management of cns metastases |
| topic | brain metastases delivery of health care leptomeningeal metastases tumor board |
| url | https://www.mdpi.com/2077-0383/12/12/3901 |
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