The Functional Impact of Alternative Splicing in Cancer
Alternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for tumor progression and therapy. However, their functional impact and relevance to tumorigenesis remain mostly unknown. We carried out a systematic analysis to characterize the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-08-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221112471731104X |
| _version_ | 1818516523068686336 |
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| author | Héctor Climente-González Eduard Porta-Pardo Adam Godzik Eduardo Eyras |
| author_facet | Héctor Climente-González Eduard Porta-Pardo Adam Godzik Eduardo Eyras |
| author_sort | Héctor Climente-González |
| collection | DOAJ |
| description | Alternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for tumor progression and therapy. However, their functional impact and relevance to tumorigenesis remain mostly unknown. We carried out a systematic analysis to characterize the potential functional consequences of alternative splicing changes in thousands of tumor samples. This analysis revealed that a subset of alternative splicing changes affect protein domain families that are frequently mutated in tumors and potentially disrupt protein-protein interactions in cancer-related pathways. Moreover, there was a negative correlation between the number of these alternative splicing changes in a sample and the number of somatic mutations in drivers. We propose that a subset of the alternative splicing changes observed in tumors may represent independent oncogenic processes that could be relevant to explain the functional transformations in cancer, and some of them could potentially be considered alternative splicing drivers (AS drivers). |
| first_indexed | 2024-12-11T00:43:24Z |
| format | Article |
| id | doaj.art-ccfd6e75025e4aad9051ace01ec489a8 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T00:43:24Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-ccfd6e75025e4aad9051ace01ec489a82022-12-22T01:26:50ZengElsevierCell Reports2211-12472017-08-012092215222610.1016/j.celrep.2017.08.012The Functional Impact of Alternative Splicing in CancerHéctor Climente-González0Eduard Porta-Pardo1Adam Godzik2Eduardo Eyras3Computational RNA Biology Group, Pompeu Fabra University (UPF), 08003 Barcelona, SpainSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USASanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USAComputational RNA Biology Group, Pompeu Fabra University (UPF), 08003 Barcelona, SpainAlternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for tumor progression and therapy. However, their functional impact and relevance to tumorigenesis remain mostly unknown. We carried out a systematic analysis to characterize the potential functional consequences of alternative splicing changes in thousands of tumor samples. This analysis revealed that a subset of alternative splicing changes affect protein domain families that are frequently mutated in tumors and potentially disrupt protein-protein interactions in cancer-related pathways. Moreover, there was a negative correlation between the number of these alternative splicing changes in a sample and the number of somatic mutations in drivers. We propose that a subset of the alternative splicing changes observed in tumors may represent independent oncogenic processes that could be relevant to explain the functional transformations in cancer, and some of them could potentially be considered alternative splicing drivers (AS drivers).http://www.sciencedirect.com/science/article/pii/S221112471731104Xalternative splicingtranscript isoformsisoform switchcancerprotein domainsprotein-protein interactionsnetworkscancer driversTCGA |
| spellingShingle | Héctor Climente-González Eduard Porta-Pardo Adam Godzik Eduardo Eyras The Functional Impact of Alternative Splicing in Cancer Cell Reports alternative splicing transcript isoforms isoform switch cancer protein domains protein-protein interactions networks cancer drivers TCGA |
| title | The Functional Impact of Alternative Splicing in Cancer |
| title_full | The Functional Impact of Alternative Splicing in Cancer |
| title_fullStr | The Functional Impact of Alternative Splicing in Cancer |
| title_full_unstemmed | The Functional Impact of Alternative Splicing in Cancer |
| title_short | The Functional Impact of Alternative Splicing in Cancer |
| title_sort | functional impact of alternative splicing in cancer |
| topic | alternative splicing transcript isoforms isoform switch cancer protein domains protein-protein interactions networks cancer drivers TCGA |
| url | http://www.sciencedirect.com/science/article/pii/S221112471731104X |
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